ecrin-mdr-crcClinical2018First line advanced Colorectal patients eligible for treatment with 5-FU, oxaliplatin, and bevacizumab.Colorectal cancer stage IVColorectal Cancer Stage IvFirst Line Advanced Colorectal Patients Eligible For Treatment With 5-fu, Oxaliplatin, And Bevacizumab.Interventionalhttps://newmdr.ecrin.org/Study/2537477GreeceCanadaAustriaSwedenUnited StatesJapanAustraliaFranceGermany11Arfolitixorin powder for solution for injectionCalcium folinateECRIN MDRTerminatedfalseA randomized, multicenter, parallel-group, Phase III study to compare the efficacy of arfolitixorin versus leucovorin in combination with 5 fluorouracil, oxaliplatin, and bevacizumab in patients with advanced colorectal cancer.Primary objectives: Overall response rate (ORR) Primary endpoints: Best ORR, defined as the best response recorded from the start of the study treatment until the end of treatment.2018-11-1525374772017-004154-41