ecrin-mdr-crcClinical2014Previously treated metastatic colorectal cancerPreviously Treated Metastatic Colorectal CancerInterventionalhttps://newmdr.ecrin.org/Study/2629998Japan7ECRIN MDRRecruitingfalsePhase II study of dose-escalation of Regorafenib for patients with previously treated metastatic colorectal cancer.Interventions: Regorafenib is administered orally once daily for 21 days followed by 7 days rest. The initial dose of regorafenib is 80mg/day, and dose-escalation to 120mg or 160mg/day should be considered every two weeks. Primary outcome(s): Time to Treatment Failure Study Design: Single arm Non-randomized2014-07-152629998JPRN-UMIN000014661