ecrin-mdr-crcClinical2022hepatocellular carcinomaHepatocellular CarcinomaInterventionalhttps://newmdr.ecrin.org/Study/38658China5ECRIN MDRNot yet recruitingfalseEffects of intestinal microflora transplantation on the efficacy of PD-1 monoclonal antibody combined with TKI in the treatment of patients with secondary drug resistance to advanced liver cancerInterventions: Experimental group:Tirelizumab combined with TKI therapy, after disease control, patients with further progression were treated with intestinal flora transplantation based on the original regimen Primary outcome(s): Disease control rate Study Design: Single arm2022-05-1538658ChiCTR2200058471