{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"contact_person":["Andrew Futreal"],"full_dataset_link":["https://ega-archive.org/dacs/EGAC00001000223"],"host":["EGA"],"description":["EGA DAC EGAC00001000223"],"repository":["EGA"],"email":["afutreal@mdanderson.org"],"pubmed_abstract":["Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We applied multiregion whole-exome sequencing (WES) on 11 localized lung adenocarcinomas. All tumors showed clear evidence of ITH. On average, 76% of all mutations and 20 out of 21 known cancer gene mutations were identified in all regions of individual tumors, which suggested that single-region sequencing may be adequate to identify the majority of known cancer gene mutations in localized lung adenocarcinomas. With a median follow-up of 21 months after surgery, three patients have relapsed, and all three patients had significantly larger fractions of subclonal mutations in their primary tumors than patients without relapse. These data indicate that a larger subclonal mutation fraction may be associated with increased likelihood of postsurgical relapse in patients with localized lung adenocarcinomas."],"pubmed_title":["Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing."],"pubmed_authors":["Zhang Jianjun J, Fujimoto Junya J, Zhang Jianhua J, Wedge David C DC, Song Xingzhi X, Zhang Jiexin J, Seth Sahil S, Chow Chi-Wan CW, Cao Yu Y, Gumbs Curtis C, Gold Kathryn A KA, Kalhor Neda N, Little Latasha L, Mahadeshwar Harshad H, Moran Cesar C, Protopopov Alexei A, Sun Huandong H, Tang Jiabin J, Wu Xifeng X, Ye Yuanqing Y, William William N WN, Lee J Jack JJ, Heymach John V JV, Hong Waun Ki WK, Swisher Stephen S, Wistuba Ignacio I II, Futreal P Andrew PA"],"additional_accession":[]},"is_claimable":false,"name":"Andy Futreal","description":"Data Access Committee EGAC00001000223","dates":{"output":"2025-1-9"},"accession":"EGAC00001000223","cross_references":{"TAXONOMY":["9606"],"pubmed":["25301631"],"EGA":["EGAS00001001542","EGAS00001000930","EGAD00001001692","EGAD00001000985","EGAD00001000984"]}}