{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"contact_person":["Johnny Ludvigsson"],"full_dataset_link":["https://ega-archive.org/dacs/EGAC00001000281"],"host":["EGA"],"description":["EGA DAC EGAC00001000281"],"repository":["EGA"],"email":["johnny.ludvigsson@lio.se"],"pubmed_abstract":["<h4>Background</h4>Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes, but to understand the pathways that lead to disease, we also need to study the epigenetic link prospectively in children.<h4>Results</h4>Here, we studied a homogenous group of 48 5-year-old children. By combining hair cortisol measurements (a well-documented biomarker for chronic stress), with whole-genome DNA-methylation sequencing, we show that high cortisol associates with a genome-wide decrease in DNA methylation and targets short interspersed nuclear elements (SINEs; a type of retrotransposon) and genes important for calcium transport: phenomena commonly affected in stress-related diseases and in biological aging. More importantly, we identify a zinc-finger transcription factor, ZNF263, whose binding sites where highly overrepresented in regions experiencing methylation loss. This type of zinc-finger protein has previously shown to be involved in the defense against retrotransposons.<h4>Conclusions</h4>Our results show that stress in preschool children leads to changes in DNA methylation similar to those seen in biological aging. We suggest that this may affect future disease susceptibility by alterations in the epigenetic mechanisms that keep retrotransposons dormant. Future treatments for stress- and age-related diseases may therefore seek to target zinc-finger proteins that epigenetically control retrotransposon reactivation, such as ZNF263."],"pubmed_title":["High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases."],"pubmed_authors":["Nätt Daniel D, Johansson Ingela I, Faresjö Tomas T, Ludvigsson Johnny J, Thorsell Annika A"],"name_synonyms":["CDAC."],"pubmed_title_synonyms":["(11beta)-, other disease, Cortifair, Cortisol, FPM315, 21-trihydroxy-, 17alpha, disorders, Kendall's compound F, 4-pregnen-11beta, DNA Methylations, 11-Epicortisol, 17-hydroxycorticosterone, Mdu, CG11121, 11, Concept, Pregn-4-ene-3, 17, old, Role Concept, diseases, DmelCG11121, Roles, 11 Epicortisol, mda, Cortril, Diseases, Role, (9 beta, Concepts, disease or disorder, condition, 21-Trihydroxy-4-pregnene-3, hydrocortisonum, diseases and disorders, (11beta)-11, hydrocortisone, ami, 21-triol-3, ZKSCAN12, (11 alpha)-Isomer, human disease, 21-trihydroxy-4-pregnene-3, somda, DNA methylation maintenance, Cortef, Hydrocortisone, med, 20-dione, DNA methylation, Children, Reichstein's substance M, SO, loss of, non-neoplastic, 21-trihydroxypregn-4-ene-3, disease, 11 alpha)-Isomer, Epicortisol, 11beta, Role Concepts, hidrocortisona, disorder, Homo sapiens disease, medical condition., 10 alpha, DNA, ZSCAN44, 11beta-hydrocortisone, Methylations, So, Methylation, Drl"],"pubmed_abstract_synonyms":["T-cell leukemia, MAJOR DEPRESSIVE DIS, Disorders, Other diseases of pericardium (disorder), Materials, Surrogate Endpoints, Cardiovascular disease, 21-trihydroxy-, Laboratory, Other pericardial disease NOS (disorder), AGL4, Cardiovascular disorder, PAPILLARY MUSCLE DIS NEC, A4, DNA Methylations, prevention, Hair, unspecified, Disease of cardiovascular system (disorder), Biological, Other heart disease NOS, 21-Trihydroxy-4-pregnene-3, hydrocortisonum, adult, 21-triol-3, Cardiovascular Diseases, gamma sarcoglycan, Senescence, thymus nucleic acid, Fetal Hairs, Endogenous Depressions, Cortef, Genomes, Moods, [X]Other forms of heart disease (disorder), vibrissa, Other ill-defined heart disease (disorder), F10N7_150, Depressive Neuroses, circulatory system disease, Epigenomic, set, Biological Aging, Disorder of cardiovascular system, Homo sapiens disease, major depressive disorder, zinc ion regulated proximal promoter sequence-specific DNA binding, TRANSCRIPTION FACTOR, RNA polymerase II distal enhancer sequence-specific binding, (11beta)-, Zn(II), RNA polymerase II core promoter proximal region sequence-specific binding, Circulatory system disease NOS (disorder), preventive therapy, Viral, fore digit, Endogenous, Hairs, zincum, disease of subdivision of hemolymphoid system, digit, Zn2+, Depressive Symptom, Marker, (9 beta, anxiety, atomo, sarcoglycan, Emotional, cinc, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity, desoxyribose nucleic acid, atome, CARDIOVASC DIS, Symptoms, End Points, atoms, 20-dione, Disorder of the circulatory system, manual digit (phalangeal portion) plus soft tissue, F14P3_4, [X]Other ill-defined heart diseases (disorder), Immunologic, whole genome, Laboratory Marker, Children, Transcription factor, AGE, diatheses, Material, 35kD dystrophin-associated glycoprotein, ILL-DEFINED HRT DIS NEC, ds DNA, copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, DNA, ZSCAN44, Disease affecting entire cardiovascular system, Epigenetics, metal ion regulated sequence-specific DNA binding, mitochondrial sodium/calcium ion exchange, Cortifair, Emotional Depression, Cardiovascular system disease, DNS, digit of hand, (Deoxyribonucleotide)n, Diatheses, Clinical Marker, Psychosis, 4-pregnen-11beta, Other diseases of pericardium, SEPALLATA 2, Other disorders of papillary muscle, Adverse, protein-containing complex, Transcription Factor, zinc, unspecified (disorder), Disorder of cardiovascular system (disorder), Susceptibility, Cardiac, zinc ion regulated core promoter proximal region sequence-specific DNA binding, Deoxyribonucleic Acid, Sites, Gene Products, disease or disorder, (11beta)-11, MAM, gamma-SG, Other ill-defined heart disease NOS (disorder), increase in risk, Unspecified circulatory system disorder, Paraphrenia, Transcription, Clinical, Neurosis, Double Stranded, Other forms of heart disease, Deoxyribonucleic acid, Other specified pericardial disease NOS, Symptom, cardiovascular disease, Zink, quill, RNA polymerase II proximal promoter sequence-specific DNA binding, copper ion regulated proximal promoter sequence-specific DNA binding, Syndrome, hidrocortisona, 10 alpha, (Deoxyribonucleotide)m, Combining Sites, Methylations, atom, Biologic, OTHER SEQUELAE OF MI NEC, Drl, fur, grupo, Cortisol, 35 kDa dystrophin-associated glycoprotein, 17alpha, DNAn+1, Affects, Involutional Psychoses, Serum Markers, Proteins, disorders, changes in DNA methylation, zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, homeobox 1, Factor, Disease affecting entire cardiovascular system (disorder), SGCG, Mdu, Immune Marker, N-acetyl-D-glucosamine 2-epimerase, native protein, mda, 11 Epicortisol, Surrogate End Point, RNA polymerase II transcription factor activity, condition, hydrocortisone, background, Other ill-defined heart disease NOS, ami, Biologic Markers, Other specified diseases of pericardium, ZKSCAN12, susceptibility, (11 alpha)-Isomer, Cardiovascular, Disease Susceptibilities, DMDA1, ensemble, [X]Other ill-defined heart diseases, Hydrocortisone, Surrogate, med, prophylaxis, Endpoints, Neuroses, Combining, [X]Other forms of heart disease, Other sequelae of myocardial infarction, metal ion regulated core promoter proximal region sequence-specific binding, Reichstein's substance M, microchaeta, F10N7.150, CVS disease, Neurotic, Gene Proteins, Depressive Disorder, control, sodium:calcium exchange, Desoxyribonukleinsaeure, Major, Unipolar Depressions, coat hair, 11beta-hydrocortisone, susceptibilities, Immune Markers, setulae, MGC130048, Biological Markers, Viral Marker, FPM315, Involutional Psychosis, adult stage, Other heart disease NOS (disorder), Biochemical, Kendall's compound F, Endpoint, protein, Cardiac Event, Aging, Serum, [X]Other specified diseases of pericardium (disorder), CG11121, element, 11, digit of manus, Laboratory Markers, old, 17, diseases, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, CVD, diseases and disorders, Depressive Symptoms, protein aggregate, first finger, prevention and control, human disease, 21-trihydroxy-4-pregnene-3, DNA methylation maintenance, reference sample, Unipolar, Other diseases of endocardium, DNA methylation, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, SO, Involutional, preventive measures, Immune, 30Zn, 11 alpha)-Isomer, Markers, Fetal, Viral Markers, 11beta, AGAMOUS-like 4, Therapies, gamma-sarcoglycan, Double-Stranded DNA, sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity, deoxyribonucleic acids, Major Depressive Disorders, DNAn, Event, So, Therapy, wide/broad, Diathesis, Surrogate Endpoint, SG-gamma, Psychoses, Disorder of circulatory system, Biochemical Markers, Double-Stranded, metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity, Biologic Marker, results, Binding, (Deoxyribonucleotide)n+m, shortened, RENBP, Diseases, Adverse Cardiac Event, Cortril, Genetic Materials, NOS, Other pericardial disease NOS, Adults, Genetic Material, CIRCULATORY DISEASE NOS, F14P3.4, whisker, Element, Factors, Epigenetic, Adverse Cardiac Events, gamma (35kDa dystrophin-associated glycoprotein), DEPRESSIVE DIS MAJOR, Treatments, disease, wide, DMDA, Depressive Syndromes, Finger, Syndromes, Epicortisol, Depression, Depressive Syndrome, Biochemical Marker, Cistron, short, Methylation, hand digit, metal ion regulated proximal promoter sequence-specific DNA binding, Gruppe, Cardiovascular Disorders, other disease, ASCVD, SGCG_HUMAN, Clinical Markers, Other heart disease (disorder), Gene, disease susceptibilities, major depressive disorder 2, broad, major depressive disorder 1, TYPE, Deoxyribonucleic acids, Surrogate End Points, DAGA4, [X]Cardiovascular disease, Surrogate Markers, Depressions, DmelCG11121, 35DAG, Mood, Depressive, SCG3, Lanugo, Site, study, Biomarker, Other diseases of endocardium (disorder), somda, [X]Other specified diseases of pericardium, Fetal Hair, Genetic, coat/ hair, Biological Marker, Other heart disease, stubby, Zn, non-neoplastic, finger, Combining Site, Neurotic Depressions, Immunologic Markers, diathesis, Endogenous Depression, grupos, Disorder, Emotional Depressions, disorder, Disease of cardiovascular system, FPM315., elements, Immunologic Marker, Neurotic Depression, Circulatory system disease NOS, Controlled, Disease, Controlling, Other ill-defined heart diseases, protein complex, RnBP, not elsewhere classified, Involutional Depression, End Point, GlcNAc 2-epimerase, medical condition, Binding Site, 11-Epicortisol, Cistrons, 17-hydroxycorticosterone, Other ill-defined heart disease, group, LGMD2C, transcription factor activity, Pregn-4-ene-3, Cardiac Events, Protein, atomus, methylation, ds-DNA, Other forms of heart disease (disorder), metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, DEPRESSIVE DIS, PERICARDIAL DISEASE NEC, KNOTTED1-like homeobox gene 5, Depressive Disorders, Serum Marker, Depressive Neurosis, Rest, hair, copper ion regulated core promoter proximal region sequence-specific binding, Surrogate Marker, introduction, Susceptibilities, Cardiovascular Disease, Protein Gene Products, 21-trihydroxypregn-4-ene-3, Other specified pericardial disease NOS (disorder), Therapeutic, digitus manus, SCARMD2, renin-binding protein, Treatment, Major Adverse Cardiac Events, Major Depressive, forelimb digit, groupe"],"additional_accession":[]},"is_claimable":false,"name":"ABIS-CDAC","description":"Data Access Committee EGAC00001000281","dates":{"output":"2025-1-9"},"accession":"EGAC00001000281","cross_references":{"TAXONOMY":["9606"],"pubmed":["26339299"],"EGA":["EGAS00001001099","EGAD00001001221"]}}