EGAGenomicsDaniel Chubbhttps://ega-archive.org/dacs/EGAC00001000303EGAEGA DAC EGAC00001000303EGADaniel.Chubb@icr.ac.ukMultiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we develop a capture Hi-C (cHi-C) approach to allow an agnostic characterization of these physical interactions on a genome-wide scale. Single-nucleotide polymorphisms associated with complex diseases often reside within regulatory elements and exert effects through long-range regulation of gene expression. Applying this cHi-C approach to 14 colorectal cancer risk loci allows us to identify key long-range chromatin interactions in cis and trans involving these loci.Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.Jäger Roland R, Migliorini Gabriele G, Henrion Marc M, Kandaswamy Radhika R, Speedy Helen E HE, Heindl Andreas A, Whiffin Nicola N, Carnicer Maria J MJ, Broome Laura L, Dryden Nicola N, Nagano Takashi T, Schoenfelder Stefan S, Enge Martin M, Yuan Yinyin Y, Taipale Jussi J, Fraser Peter P, Fletcher Olivia O, Houlston Richard S RSfalseMolecular and Population Genetics (MPG) research at ICR DAC agreementData Access Committee EGAC00001000303EGAC00001000303960625695508EGAS00001001084EGAS00001001085EGAD00001001243EGAD00001001222