EGAGenomicsPeter De Rijkhttps://ega-archive.org/dacs/EGAC00001000395EGAEGA DAC EGAC00001000395EGAPeter.DeRijk@molgen.vib-ua.beAs regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells. Analysis of the consequences of the altered miR-204 expression on the transcriptome of these cells uncovered a new mode of action for miR-204, being the regulation of noncoding RNAs (ncRNAs), including several miRNAs, such as MIR296. Furthermore, pathway analysis showed downstream effects of miR-204 on neurotransmitter and ion channel related gene sets, potentially mediated by miRNAs regulated through miR-204.Schizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets.Cammaerts Sophia S, Strazisar Mojca M, Smets Bart B, Weckhuysen Sarah S, Nordin Annelie A, De Jonghe Peter P, Adolfsson Rolf R, De Rijk Peter P, Del Favero Jurgen Jfbwd4, AMGX, l(2)04454, DmelCG1772, dac, CIB1, AMGL, AIH1, LRAP, p21[dacapo], anterior midline glia., Amg, MG, dactylin, AMG, E130112M23Rik, cdi4, dactylyn, heredity, M100888, p21, ., CG1772, FBWD4, Cdi4, CDI4, p27, midline glia, Rgsc888, median glial cell, Decapo, AI1E, ALGN, shsf3, shfm3, E(Sev-CycE)2B, Fbw4, FBW4, ventral midline glia, Dach, CDKN2B, SHFM3, MGA, Dac, DAC, p27[Dap], dacapo/cyclin-dependent kinase interactor 4, Amel, AI182278, Dap, MGM, CES5A1, P15, fbw4, SHSF3SCHIZO NEC-CHR/EXACERB, Disorders, Materials, ion, schizophrenia, SCHIZO NEC-SUBCHR/EXACER, Nerve, Substances, Gene, neurotransmitters, Cistrons, unspecified (disorder), Neurohumor, schizophrenia with or without an affective disorder, Schizophrenia NOS, unspecified, Neuromodulators, Dementia Praecox, SCHIZO NOS-CHR/EXACERB, Ionen, Transmitter Substance, Other specified types of schizophrenia, Schizophrenic disorders (disorder), SCHIZOPHRENIA NEC-SUBCHR, chronic state, SCHIZOPHRENIA NEC-CHR, Schizophrenias, unspecified state, Genetic Materials, Neuromodulator, subchronic state with acute exacerbation, Unspecified schizophrenia, subchronic state, SCHIZOPHRENIA NEC-UNSPEC, [X]Schizophrenia, Schizophrenia (disorder), Neurotransmitter Agent, Unspecified schizophrenia (disorder), Genetic, Schizophrenic, iones, susceptibility to, Neurohumors, Schizophrenic disorders, INSDC_feature:gene, Schizophrenic Disorder, Schizophrenia NOS (disorder), Substance, ions, SCZD, schizoaffective disorder, in remission, Schizophrenic Disorders, Nerve Transmitter, Ion, Nerve Transmitter Substance, Transmitter Substances, Material, Neuroregulators, Disorder, Neurotransmitters, chronic state with acute exacerbation, Cistron, associated, Nerve Transmitter Substances, Genetic Material., SCHIZOPHRENIA NOS-UNSPEC, SCHIZOPHRENIA NEC-REMISS, Neurohormones, Neurotransmitter, Neurohormone, Neuroregulator, SCHIZO NOS-SUBCHR/EXACERSH-SY5Y, scale tissue, Materials, Disorders, single-organism developmental process, ion, determination, acetylglucosaminyltransferase-like protein, postnatal development, Mbp1, bar, Gene Expression Profile, growth and development, Profiles, IDOL, Social Controls, Small, unspecified, Dementia Praecox, anon-WO0134654.19, DmelCG4637, diseases, Roles, chronic state, Concepts, unspecified state, diseases and disorders, Mir, MIR, Unspecified schizophrenia, myd, Formal Social Controls, Miranda, SCHIZOPHRENIA NEC-UNSPEC, Neurotransmitter Agent, human disease, Small Temporal, Gene Expressions, Unspecified schizophrenia 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LDL-receptor, Controls, LARGE_HUMAN, Schizophrenic Disorders, disease, MDC1D, enr, spine, Material, Nerve Transmitter Substance, Transmitter Substances, Neuroregulators, MIRA, MicroRNA, Cistron, chronic state with acute exacerbation, Nerve Transmitter Substances, Regulation, hg, HH, Regulations, other disease, Plays, Transcriptome Profile, stRNA, hg., peltate hair, Nerve, Substances, Gene, neurotransmitters, LARGE1, froggy, Gyltl1a, unspecified (disorder), protrusion, Hh, schizophrenia with or without an affective disorder, Schizophrenia NOS, SCHIZO NOS-CHR/EXACERB, reduced, Other specified types of schizophrenia, disease or disorder, tiny, subchronic state, Toy, study, Schizophrenia (disorder), Genetic, MONDOA, Playthings, MDDGB6, iones, Mrt, Profile, LARGE, Schizophrenic Disorder, ions, Expressions, SCZD, schizoaffective disorder, non-neoplastic, BPFD#36, Myosin regulatory light chain-interacting protein, Puppets, bar-3, Disorder, Play, disorder, Expression, bHLHe36, SCHIZOPHRENIA NEC-REMISS, Neurohormones, Neurotransmitter, Neurohormone, pre miRNA, Puppet, small, RNA, l(3)hh, SCHIZO NEC-CHR/EXACERB, Transcriptome, Formal Social Control, schizophrenia, Myosin regulatory light chain interacting protein, SCHIZO NEC-SUBCHR/EXACER, disorders, Primary, medical condition, Cistrons, Cell, Concept, development, AW228700, Neuromodulators, Micro RNA, Social Control, Schizophrenic disorders (disorder), chemical analysis, Gene Expression Signatures, SCHIZOPHRENIA NEC-CHR, condition, DmelCG12249, Gene Expression Signature, scales, subchronic state with acute exacerbation, scale, Schizophrenic, underdeveloped, Temporal RNA, Neurohumors, postnatal growth, Primary MicroRNA, Schizophrenia NOS (disorder), in remission, like-glycosyltransferase, anon-WO0182946.19, Ion, Gene Expression Profiles, regulation, assay, Signature, SCHIZOPHRENIA NOS-UNSPEC, growth, Neuroregulator, glycosyltransferase-like protein LARGE1falseVIB Department of Molecular Genetics DAC AMG and NGData Access 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