{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"contact_person":["Chris Hovens"],"full_dataset_link":["https://ega-archive.org/dacs/EGAC00001000586"],"host":["EGA"],"description":["EGA DAC EGAC00001000586"],"repository":["EGA"],"email":["chovens@unimelb.edu.au"],"pubmed_abstract":["The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes have a better prognosis than those with distant metastatic spread, suggesting the possibility of distinct aetiologies. To explore this, we traced patterns of cancer dissemination using tumour phylogenies inferred from genome-wide copy-number profiling of 48 samples across 3 patients with lymph node metastatic disease and 3 patients with osseous metastatic disease. Our results show that metastatic cells in regional lymph nodes originate from evolutionary advanced extraprostatic tumour cells rather than less advanced central tumour cell populations. In contrast, osseous metastases do not exhibit such a constrained developmental lineage, arising from either intra or extraprostatic tumour cell populations, at early and late stages in the evolution of the primary. Collectively, this comparison suggests that lymph node metastases may not be an intermediate developmental step for distant osseous metastases, but rather represent a distinct metastatic lineage."],"pubmed_title":["Comparing nodal versus bony metastatic spread using tumour phylogenies."],"pubmed_authors":["Mangiola Stefano S, Hong Matthew K H MK, Cmero Marek M, Kurganovs Natalie N, Ryan Andrew A, Costello Anthony J AJ, Corcoran Niall M NM, Macintyre Geoff G, Hovens Christopher M CM"],"pubmed_title_synonyms":["xnr4, nr4, metastatic, Tg.413d, nodal4, bony, nodal4-A, HTX5, NODAL, other neoplasm."],"name_synonyms":["fbwd4, Data Set., hereditary prostate cancer, l(2)04454, DmelCG1772, cancer of the prostate, dac, Node, CIB1, Prostate Neoplasms, Neoplasms, lymphatic system, familial, p21[dacapo], dactylin, E130112M23Rik, cdi4, dactylyn, p21, Prostatic Cancer, Neoplasm, Prostatic Cancers, CG1772, FBWD4, Cdi4, CDI4, NOS, p27, Decapo, Cancer of Prostate, nodus lymphaticus, Prostate Cancers, Lymph, Lymph Node, shsf3, shfm3, E(Sev-CycE)2B, Cancers, Fbw4, FBW4, cancer of prostate, Prostate Neoplasm, Dach, CDKN2B, SHFM3, Prostatic Neoplasm, Lymph node, Dac, DAC, Cancer of the Prostate, p27[Dap], dacapo/cyclin-dependent kinase interactor 4, AI182278, Nodes, Prostatic, Dap, prostate cancer, CES5A1, PC, lymph gland, P15, fbw4, SHSF3, Prostate Cancer, Prostate, Cancer"],"pubmed_abstract_synonyms":["Node, GRP1/cytohesin 1, Prostate Neoplasms, Metastasis, Neoplasms, Lymph Node Metastases, Benign Neoplasm, number, Prognostic Factors, broad, Tumor, Malignant, presence, CG11633, cytohesin/GRP1, Roles, Lymph Nodes, GRP1, Grp1, Prostatic Cancers, Concepts, DmF2, Cancer of Prostate, Fs(3)Hor, Prostate Cancers, Lymph, lod, metastatic., DmelCG2684, Prognoses, tumor cell, Malignancy, Genomes, PTPSTEP, l(2)SH2 0323, NTef2, Neoplasias, Prostatic Neoplasm, Cancer of the Prostate, Neural-specific protein-tyrosine phosphatase, tumour cell, malignant neoplasm, Clients, l(2)k08110, Role Concepts, Prostatic, Malignancies, GPH, Cancer, Tumors, hereditary prostate cancer, cancer of the prostate, Malignant Neoplasm, wide/broad, lymphatic system, familial, Lymph Node Metastasis, stepk, Factor, Client, results, Cell, metastatic neoplasm, Fs(3)Sz11, Concept, count in organism, metastatic disease, Role Concept, MT, Benign, Prostatic Cancer, 3.1.3.48, Role, Neoplasm, NOS, l(2)SH0323, nodus lymphaticus, CYH1, primary cancer, Factors, Exhibit, distinct, Lymph Node, Step, CG11628, Prognostic, Benign Neoplasms, Lymphatic Metastases, Striatum-enriched protein-tyrosine phosphatase, Cancers, whole genome, Lds, cancer of prostate, malignant tumor, Prostate Neoplasm, early, DmelCG11628, Malignant Neoplasms, metastatic, wide, Lymph node, Patient, STEP, Horka, metastatic tumor, Nodes, cardinality, metastatic tumour, CG2684, Fs(3)Horka, prostate cancer, PC, lymph gland, other neoplasm, Prostate Cancer, Neoplasia, Prostate, Prognostic Factor"],"additional_accession":[]},"is_claimable":false,"name":"DAC for the Prostate Cancer Lymph Node dataset","description":"Data Access Committee EGAC00001000586","dates":{"output":"2025-1-9"},"accession":"EGAC00001000586","cross_references":{"TAXONOMY":["9606"],"pubmed":["27653089"],"EGA":["EGAS00001001801","EGAD00010001179"]}}