{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"contact_person":["Ali Torkamani, Ph.D."],"full_dataset_link":["https://ega-archive.org/dacs/EGAC00001000663"],"host":["EGA"],"description":["EGA DAC EGAC00001000663"],"repository":["EGA"],"email":["atorkama@scripps.edu"],"pubmed_abstract":["Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease. Therefore, we pursued genome sequencing of a related phenotype-healthy aging-to understand the genetics of disease-free aging without medical intervention. In contrast with studies of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known longevity variants, but is associated with reduced genetic susceptibility to Alzheimer and coronary artery disease. Additionally, healthy aging is not associated with a decreased rate of rare pathogenic variants, potentially indicating the presence of disease-resistance factors. In keeping with this possibility, we identify suggestive common and rare variant genetic associations implying that protection against cognitive decline is a genetic component of healthy aging. These findings, based on a relatively small cohort, require independent replication. Overall, our results suggest healthy aging is an overlapping but distinct phenotype from exceptional longevity that may be enriched with disease-protective genetic factors. VIDEO ABSTRACT."],"pubmed_title":["Whole-Genome Sequencing of a Healthy Aging Cohort."],"pubmed_authors":["Erikson Galina A GA, Bodian Dale L DL, Rueda Manuel M, Molparia Bhuvan B, Scott Erick R ER, Scott-Van Zeeland Ashley A AA, Topol Sarah E SE, Wineinger Nathan E NE, Niederhuber John E JE, Topol Eric J EJ, Torkamani Ali A"],"pubmed_title_synonyms":["Aging Well, Ageing, whole genome, Well, Aging, Healthy., Genomes, Healthy Ageing, Healthy, Well Aging, Ageing Well"],"name_synonyms":["study."],"pubmed_abstract_synonyms":["genetic susceptibilities, Mental, other disease, lifespan, Impairment, Disorders, Mental deterioration, predisposition, Mild, number, Cognitive Dysfunctions, Deteriorations, Aging, genetic predisposition, Dysfunctions, Coronary, presence, Intervention or Procedure, Susceptibility, Cognitive Declines, diseases, reduced, Biological, heredity, Associations, resistance, symptoms, disease or disorder, Arterioscleroses, diseases and disorders, tiny, Left Main Coronary Artery Disease, Senescence, human disease, Life Span, Genetic, Coronary Arteriosclerosis, Genetic Predisposition, Genomes, Abstract., Healthy Ageing, interventionDescription, entire lifespan, entire life cycle, Coronary Atheroscleroses, long, Length of Life, Cognitive decline, hypoplasia, Atheroscleroses, Coronary Artery Diseases, Interventional, Genetic Susceptibilities, Cognitive Disorders, free, SURGICAL AND MEDICAL PROCEDURES, genetic predispositions, Well Aging, genetic, non-neoplastic, Biological Aging, Ageing, Predispositions, Disorder, disorder, Homo sapiens disease, Deterioration, associated, constitutitional genetic, Cognitive Disorder, Lifespan, small, Intervention Strategies, Left Main Coronary Disease, Mild Cognitive Impairments, screening, coronary arteriosclerosis, Lifespans, Mild Cognitive, findings, Life Spans, Cognitive Decline, RnBP, Left Main Disease, Cognitive Impairment, familial, disorders, Impairments, GlcNAc 2-epimerase, Aging Well, medical condition, Procedure, genetic susceptibility, results, count in organism, N-acetyl-D-glucosamine 2-epimerase, Cognitive Impairments, Mild Cognitive Impairment, RENBP, Diseases, condition, Coronary Arterioscleroses, rare (European definition), Dysfunction, Arteriosclerosis, Left Main Diseases, Genetic Predispositions, Intervention, susceptibility, length of life, Well, distinct, underdeveloped, Mental Deterioration, Artery Diseases, life, Intellectual deterioration, Coronary Atherosclerosis, signs, common, whole genome, Predisposition, Atherosclerosis, Cognitive, predispositions, Healthy, Ageing Well, Susceptibilities, AGE, Progressive cognitive decline, Phenotypes, disease, Declines, Artery Disease, Coronary Artery Disease, Genetic Susceptibility, Decline, renin-binding protein, inherited genetic, progressive, hereditary, susceptibilities, Mental Deteriorations"],"additional_accession":[]},"is_claimable":false,"name":"Wellderly Study","description":"Data Access Committee EGAC00001000663","dates":{"output":"2025-1-9"},"accession":"EGAC00001000663","cross_references":{"TAXONOMY":["9606"],"pubmed":["27114037"],"EGA":["EGAS00001002306","EGAD00001003941"]}}