{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"contact_person":["Ruidong Xue"],"full_dataset_link":["https://ega-archive.org/dacs/EGAC00001001273"],"host":["EGA"],"description":["EGA DAC EGAC00001001273"],"repository":["EGA"],"email":["08082@pkufh.com"],"pubmed_abstract":["We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC."],"pubmed_title":["Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes."],"pubmed_authors":["Xue Ruidong R, Chen Lu L, Zhang Chong C, Fujita Masashi M, Li Ruoyan R, Yan Shu-Mei SM, Ong Choon Kiat CK, Liao Xiwen X, Gao Qiang Q, Sasagawa Shota S, Li Yanmeng Y, Wang Jincheng J, Guo Hua H, Huang Qi-Tao QT, Zhong Qian Q, Tan Jing J, Qi Lisha L, Gong Wenchen W, Hong Zhixian Z, Li Meng M, Zhao Jingmin J, Peng Tao T, Lu Yinying Y, Lim Kiat Hon Tony KHT, Boot Arnoud A, Ono Atushi A, Chayama Kazuaki K, Zhang Zemin Z, Rozen Steve George SG, Teh Bin Tean BT, Wang Xin Wei XW, Nakagawa Hidewaki H, Zeng Mu-Sheng MS, Bai Fan F, Zhang Ning N"],"name_synonyms":["fbwd4, DmelCG7399, l(2)04454, DmelCG1772, Non-phenylketonuria hyperphenylalaninemia, dac, oligophrenia Phenylpyruvica, CIB1, TRH, Trh, imbecilitus phenylpyruvica, \"PKU\" EXACT [MTH:NOCODE], PKU1, pah, p21[dacapo], dactylin, phenylketonuria, E130112M23Rik, Phenylketonuria, cdi4, DTPH, dactylyn, p21, \"Phenylketonuria [PKU]\" EXACT [ICD9CM_2006:270.1], CG1772, FBWD4, Cdi4, CDI4, p27, CG7399, HPA, PKU, \"PKU\" EXACT [CSP2005:1849-1234], maternal, TPH, Tph, shsf3, non-PKU mild, shfm3, Decapo., bu, E(Sev-CycE)2B, phenylpyruvic oligophrenia, \"PKU\" EXACT [MTHICD9_2006:270.1], oligophrenia phenylpyruvica, Fbw4, FBW4, Dach, CDKN2B, SHFM3, IHCH, Dac, DAC, ICC, p27[Dap], intestinal pacemaker cell, dacapo/cyclin-dependent kinase interactor 4, AI182278, \"phenylalaninemia\" EXACT [CSP2005:1849-1177], \"Phenylketonuria\" EXACT [SNOMEDCT_2005_07_31:154735006], Dap, CES5A1, P15, PAH, Pah, fbw4, PH, SHSF3, \"Phenylketonuria\" EXACT [SNOMEDCT_2005_07_31:190687004]"],"pubmed_title_synonyms":["Cholangiocellular Carcinoma, Carcinomas, distinct., Intrahepatic Cholangiocarcinoma, Carcinoma, Extrahepatic Cholangiocarcinoma, IHCH, Cholangiocellular Carcinomas, Cholangiocarcinomas, Intrahepatic Cholangiocarcinomas, Extrahepatic, Extrahepatic Cholangiocarcinomas, Intrahepatic, Cholangiocellular, Cholangiocarcinoma"],"pubmed_abstract_synonyms":["MGC130048, Pfeiffer's disease (disorder), Biological Markers, Viral Marker, Extrahepatic Cholangiocarcinoma, SGCG_HUMAN, Surrogate Endpoints, determination, Clinical Markers, Laboratory, Clinical Marker, Neoplasms, Intrahepatic Cholangiocarcinomas, Benign Neoplasm, Biochemical, A4, Cell Carcinoma, Endpoint, Lasers, Mononucleosis, adult hepatoma, Tumor, Serum, Hepatomas, Intrahepatic, Malignant, Liver Cell Carcinoma, TYPE, Surrogate End Points, DAGA4, Cell Carcinomas, Surrogate Markers, Laboratory Markers, Mono, Liver Cell Carcinomas, Biological, Pulsed, Microdissections, 35DAG, Adult Liver Cancer, cell fraction, Masers, MAM, gamma-SG, SCG3, Cholangiocellular Carcinoma, Gammaherpesviral mononucleosis (disorder), gamma sarcoglycan, Nestin, Biomarker, Maser, Pulsed Lasers, Clinical, Liver Cancer, Malignancy, Biological Marker, Extrahepatic, adult primary hepatocellular carcinoma, Liver Cancers, mononucleosis, Adult, snRNA-seq, Hepatocellular Carcinoma, Continuous Wave, Neoplasias, Intrahepatic Cholangiocarcinoma, Continuous Wave Laser, Q-Switched Lasers, Immunologic Markers, Immune, intestinal pacemaker cell., glandular fever, Markers, ICC, intestinal pacemaker cell, malignant neoplasm, Infectious Mononucleosis, Pfeiffer's disease, Viral Markers, Cholangiocarcinomas, gamma-sarcoglycan, Malignancies, Gammaherpesviral mononucleosis, Immunologic Marker, Biologic, Cancer, Tumors, Carcinoma, Liver, Viral, Malignant Neoplasm, Surrogate Endpoint, 35 kDa dystrophin-associated glycoprotein, Continuous Wave Lasers, Serum Markers, SG-gamma, Q Switched Lasers, End Point, Liver Cell, Biochemical Markers, Cholangiocellular, Biologic Marker, results, SGCG, light amplification by the stimulated emission of radiation, LGMD2C, Immune Marker, MT, Benign, HCC, Cholangiocellular Carcinomas, Marker, Surrogate End Point, chemical analysis, Protein, Neoplasm, sarcoglycan, Kissing disease, Adult Liver, Extrahepatic Cholangiocarcinomas, Biologic Markers, Carcinomas, Q-Switched Laser, primary cancer, Serum Marker, Adult Liver Cancers, Hepatocellular carcinoma, DMDA1, distinct, End Points, Hepatoma, Surrogate, Nestin Protein, Endpoints, Benign Neoplasms, Pulsed Laser, Glandular Fever, Cancers, Immunologic, Laboratory Marker, gamma (35kDa dystrophin-associated glycoprotein), malignant tumor, Surrogate Marker, Cholangiocarcinoma, Malignant Neoplasms, infectious mononucleosis, IHCH, DMDA, Q-Switched, Biochemical Marker, 35kD dystrophin-associated glycoprotein, SCARMD2, Monocytic angina, Filatov's disease, Hepatocellular, monocytic angina, assay, Glandular fever, Hepatocellular Carcinomas, Laser, Neoplasia, Immune Markers"],"additional_accession":[]},"is_claimable":false,"name":"PKU_cHCC-ICC DAC","description":"Data Access Committee EGAC00001001273","dates":{"output":"2025-1-9"},"accession":"EGAC00001001273","cross_references":{"TAXONOMY":["9606"],"pubmed":["31130341"],"EGA":["EGAS00001003093","EGAD00001005182","EGAD00001005183","EGAD00001005181"]}}