EGAGenomicsHeli Viljakainenhttps://ega-archive.org/dacs/EGAC00001002638EGAEGA DAC EGAC00001002638EGAheli.viljakainen@helsinki.fi<h4>Objective</h4>The human intestinal microbiota likely play an important role in the development of overweight and obesity. However, the associations between saliva microbiota and body mass index (BMI) have been sparsely studied. The aim of this study was to identify the associations between saliva microbiota and body size in Finnish children.<h4>Methods</h4>The saliva microbiota of 900 Finnish children, aged 11-14 years with measured height and weight, was characterized using 16S rRNA (V3-V4) sequencing.<h4>Results</h4>The core saliva microbiota consisted of 14 genera that were present in more than 95% of the Finnish children. The saliva microbiota profiles were gender-specific with higher alpha-diversity in boys than girls and significant differences between the genders in community composition and abundances. Alpha-diversity differed between normal weight and overweight girls and between normal weight and obese boys. The composition was dissimilar between normal weight and obese girls, but not in boys. The relative abundance profiles differed according to body size. Decrease in commensal saliva bacteria were observed in all the body sizes when compared to normal weight children. Notably, the relative abundance of bacteria related to, <i>Veillonella</i>, <i>Prevotella</i>, <i>Selenomonas</i>, and <i>Streptococcus</i> was reduced in obese children.<h4>Conclusion</h4>Saliva microbiota diversity and composition were significantly associated with body size and gender in Finnish children. Body size-specific saliva microbiota profiles open new avenues for studying the potential roles of microbiota in weight development and management.Gender-Specific Associations Between Saliva Microbiota and Body Size.Raju Sajan C SC, Lagström Sonja S, Ellonen Pekka P, de Vos Willem M WM, Eriksson Johan G JG, Weiderpass Elisabete E, Rounge Trine B TBfbwd4, l(2)04454, DmelCG1772, Disease, sexually Transmitted infection, dac, Citron K, STI, CIB1, C76919, T8K22_22, AUB, Aub, Venereal, anon-WO0118547.388, Sexually Transmitted, CG6137, p21[dacapo], infections, l(3)7m-62, Transmitted infections, dactylin, Sexually Transmitted., DmelCG6137, E130112M23Rik, cdi4, Transmitted Infections, sexually, sti, diseases, dactylyn, DNA POLYMERASE III-LIKE PROTEIN, DCK, p21, Diseases, Infection, CG1772, FBWD4, Cdi4, CDI4, p27, T8K22.22, Venereal Disease, Decapo, venereal disease, sexually Transmitted, sexually Transmitted infections, CIT-K, l(3)7m62, l(3)SG21, infection, Transmitted infection, AI316495, Infections, venereal diseases, dck, STIs, shsf3, ms(2)32D, cit, shfm3, E(Sev-CycE)2B, Fbw4, GAMMA SUBUNIT, FBW4, venereal, Sexually, CG10522, Dach, CDKN2B, disease, SHFM3, Sexually Transmitted Disease, Dac, DAC, p27[Dap], Sexually Transmitted Infection, dacapo/cyclin-dependent kinase interactor 4, sting, AI182278, Venereal Diseases, Dap, Transmitted Infection, CES5A1, STICHEL, DmelCG10522, P15, Sexually Transmitted Infections, fbw4, STDs, SHSF3Microbial Community Composition, Community Composition, Size, Microbiomes, Microbial Community Compositions, Microbial Community, saliva atomaris, Microbial Community Structure, Community Structure, Salivas, Body Sizes, Microbial, Body, Human, sex-specific, Composition, gender-specific anatomical structure, Associations, saliva molecularis, Microbial Community Structures, gender-specific, Sizes, Microbiotas, sailva normalis, Body., Human Microbiomes, Microbial Communities, Community, Human Microbiome, MicrobiomeSize, BamF, postnatal development., single-organism developmental process, HSN1E, BamC, AP-2, postnatal development, alpha-Spe, growth and development, sulfur, CG31654, alpha-Spc, Adiposis, height, Obese, Techniques, l(3)04276, unspecified, Roles, Method, Associations, theion, Concepts, alpha-adaptin, DmelCG10422, Schwefel, animal, alpha-spec, average, Eubacteria, Man (Taxonomy), azufre, CG4260, Microbial Community Structure, hypoplasia, S, Body Sizes, procedures, Boys, alpha-spectrin, Bacteria Woese et al. 2024, Methodological Studies, Bacteria <bacteria>, Prokaryotae, Role Concepts, Microbial Community Structures, soufre, Procaryotae, CXXC finger protein 9, obese, Modern, Salivas, ham, Procedure, Microbial, results, Girl, ada, alphaSpec, D-Ada, Role Concept, weight, Playthings and Play, Obesity [Ambiguous], Obese (finding), cg4260, Role, Plaything, Sizes, prokaryotes, dAP-2a, spectrin, Microbial Communities, l(2)06694, MENE (2L)-A, ADCADN, whole organism, UNQ203/PRO229, Microbial Community Compositions, DNA (cytosine-5-)-methyltransferase 1, 16S, Toys, Adiposity, OBESITY NOS, Methodological, alpha, AP-2alpha, Children, Methodological Study, human, DmelCG4260, Composition, sex-specific, sulphur, Koerper, Human Microbiomes, Elderly, Prokaryota, Community, Microbial Community Composition, alpha-Ada, anon-EST:fe2E2, Plays, human being, l(3)alpha-Spec, Procedures, alpha-Spect, obesity disease, eubacteria, l(2)SH2 0460, Human, fs(3)neo61, Obesity, CG10422, Aim, alpha-ada, AIM, Homo sapiens, reduced, Girls, klo, saliva molecularis, Studies, alpha-Sp, Bacteriobiota, tiny, CG1977, Man, Technique, Toy, DNMT1, study, Playthings, DNMT1_HUMAN, saliva atomaris, Elemental sulfur, dre3, Overweight and obesity, Alpha-Adaptin, Monera, Study, Bacteria (ex Cavalier-Smith 1987), API6, Puppets, Play, fungi, Puppet, Human Microbiome, l(3)dre3, DNA MTase HsaI, DNA (cytosine-5)-methyltransferase 1, small, bacteria, Community Composition, alpha-Spectrin, 3A9, Women's Group, body, DmelCG1977, Women Groups, DNMT, whole body, MCMT, Woman, obesity, Concept, development, DNA methyltransferase HsaI, core, MENE(2L)-A, techniques, alphaSp, obesity disorder, Obesity (disorder), OF-900, Microbiome, CXXC9, Microbiomes, D-alphaAda, CT-2, mating_type_alpha, underdeveloped, Microbial Community, Obesity NOS, Women's Groups, postnatal growth, Community Structure, FCP-B, ob, OB, INSDC_qualifier:unknown, Selenomonas ruminantium, CXXC-type zinc finger protein 9, Body, AP2, gender-specific anatomical structure, l(3)62Bd, Bam-C, prokaryote, Modern Man, BAM, Bam, alpha mating type (yeast), l(2)SH0460, gender-specific, Microbiotas, alfa-Spec, sailva normalis, growth, CLEC2C, Spec, m.HsaI, methodologyfalseFinHIT_DAC_STIData Access Committee EGAC00001002638EGAC00001002638960631024514EGAS00001003039EGAD00001008780