{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["Affymetrix 6.0"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00000000119"],"sample_count":["51"],"description":["EGA dataset EGAD00000000119"],"repository":["EGA"],"title":["Title not provided"],"pubmed_abstract":["Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response."],"pubmed_title":["Subtype and pathway specific responses to anticancer compounds in breast cancer."],"pubmed_authors":["Heiser Laura M LM, Sadanandam Anguraj A, Kuo Wen-Lin WL, Benz Stephen C SC, Goldstein Theodore C TC, Ng Sam S, Gibb William J WJ, Wang Nicholas J NJ, Ziyad Safiyyah S, Tong Frances F, Bayani Nora N, Hu Zhi Z, Billig Jessica I JI, Dueregger Andrea A, Lewis Sophia S, Jakkula Lakshmi L, Korkola James E JE, Durinck Steffen S, Pepin François F, Guan Yinghui Y, Purdom Elizabeth E, Neuvial Pierre P, Bengtsson Henrik H, Wood Kenneth W KW, Smith Peter G PG, Vassilev Lyubomir T LT, Hennessy Bryan T BT, Greshock Joel J, Bachman Kurtis E KE, Hardwicke Mary Ann MA, Park John W JW, Marton Laurence J LJ, Wolf Denise M DM, Collisson Eric A EA, Neve Richard M RM, Mills Gordon B GB, Speed Terence P TP, Feiler Heidi S HS, Wooster Richard F RF, Haussler David D, Stuart Joshua M JM, Gray Joe W JW, Spellman Paul T PT"],"additional_accession":[]},"is_claimable":false,"name":"EGAD00000000119","description":"Genotypes from cell lines derived from breast carcinoma tissue","dates":{"updated":"2013-05-22 16:39:38"},"accession":"EGAD00000000119","cross_references":{"TAXONOMY":["9606"],"pubmed":["22003129"],"EGA":["EGAC00000000015","EGAS00000000059"]}}