EGAGenomicsN/Ahttps://ega-archive.org/datasets/EGAD0000100069112EGA dataset EGAD00001000691EGAGenomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which HPV integrant-mediated DNA replication and recombination may result in viral-host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.Akagi Keiko K, Li Jingfeng J, Broutian Tatevik R TR, Padilla-Nash Hesed H, Xiao Weihong W, Jiang Bo B, Rocco James W JW, Teknos Theodoros N TN, Kumar Bhavna B, Wangsa Danny D, He Dandan D, Ried Thomas T, Symer David E DE, Gillison Maura L MLfalseena-DATASET-OSUCCC-31-10-2013-20:19:37:619-31 - samplesWhole genome sequencing data from Illumina platform were generated using 10 human cancer cell lines and 2 primary tumor samples. Nine of these samples contained fragments of human papillomavirus (HPV).2019-10-31 12:52:10EGAD00001000691960624201445EGAC00001000141EGAS00001000599