{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["Illumina Genome Analyzer II;, Illumina HiSeq 2000;"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001001397"],"sample_count":["72"],"description":["EGA dataset EGAD00001001397"],"repository":["EGA"],"title":["BGI study for primary and metastatic Chinese lung adenocarcinomas"],"pubmed_abstract":["The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma."],"pubmed_title":["Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas."],"pubmed_authors":["Wu Kui K, Zhang Xin X, Li Fuqiang F, Xiao Dakai D, Hou Yong Y, Zhu Shida S, Liu Dongbing D, Ye Xiaofei X, Ye Mingzhi M, Yang Jie J, Shao Libin L, Pan Hui H, Lu Na N, Yu Yuan Y, Liu Liping L, Li Jin J, Huang Liyan L, Tang Hailing H, Deng Qiuhua Q, Zheng Yue Y, Peng Lihua L, Liu Geng G, Gu Xia X, He Ping P, Gu Yingying Y, Lin Weixuan W, He Huiming H, Xie Guoyun G, Liang Han H, An Na N, Wang Hui H, Teixeira Manuel M, Vieira Joana J, Liang Wenhua W, Zhao Xin X, Peng Zhiyu Z, Mu Feng F, Zhang Xiuqing X, Xu Xun X, Yang Huanming H, Kristiansen Karsten K, Wang Jian J, Zhong Nanshan N, Wang Jun J, Pan-Hammarström Qiang Q, He Jianxing J"],"additional_accession":[]},"is_claimable":false,"name":"ena-DATASET-BGI-18-06-2015-04:55:13:301-17 - samples","description":"We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.","dates":{"updated":"2017-07-26 15:39:26"},"accession":"EGAD00001001397","cross_references":{"TAXONOMY":["9606"],"pubmed":["26647728"],"EGA":["EGAC00001000177","EGAS00001000982"]}}