{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["Illumina HiSeq 2500;"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001002067"],"sample_count":["16"],"description":["EGA dataset EGAD00001002067"],"repository":["EGA"],"title":["Analysis of tumor periphery and center-specific mutations in renal cell carcinoma"],"additional_accession":[]},"is_claimable":false,"name":"ena-DATASET-MUO-27-04-2016-12:33:45:301-16 - samples","description":"Renal cell carcinoma (RCC) is a genomically heterogeneous tumor. In the present project, the question whether intratumoral heterogeneity follows a zonal pattern indicating spatial niches was addressed. Whole exome sequencing of 16 paired samples from tumor periphery and center revealed a number of region-specific functional SNVs and Indels. Therefore, RCCs are not composed of evenly admixed tumor cells but show topological differences in their clonal composition.","dates":{"updated":"2017-07-26 15:39:28"},"accession":"EGAD00001002067","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAC00001000470","EGAS00001001784"]}}