EGAGenomicsIllumina HiSeq 2500;https://ega-archive.org/datasets/EGAD0000100206716EGA dataset EGAD00001002067EGAAnalysis of tumor periphery and center-specific mutations in renal cell carcinomafalseena-DATASET-MUO-27-04-2016-12:33:45:301-16 - samplesRenal cell carcinoma (RCC) is a genomically heterogeneous tumor. In the present project, the question whether intratumoral heterogeneity follows a zonal pattern indicating spatial niches was addressed. Whole exome sequencing of 16 paired samples from tumor periphery and center revealed a number of region-specific functional SNVs and Indels. Therefore, RCCs are not composed of evenly admixed tumor cells but show topological differences in their clonal composition.2017-07-26 15:39:28EGAD000010020679606EGAC00001000470EGAS00001001784