{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics","Multiomics"],"dataset_type":["Illumina HiScanSQ;ILLUMINA"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001003143"],"sample_count":["6"],"description":["EGA dataset EGAD00001003143"],"repository":["EGA"],"title":["RNA-sequencing of six Pilocytic astrocytoma tumors"],"pubmed_abstract":["Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions and point mutations (e.g. BRAFV600E). These features may serve as diagnostic and prognostic markers, and also facilitate development of targeted therapy. The aims of this study were to characterize the genetic alterations underlying the development of PA in six tumor cases, and evaluate methods for fusion oncogene detection. Using a combined analysis of RNA sequencing and copy number variation data we identified a new BRAF fusion involving the 5' gene fusion partner GTF2I (7q11.23), not previously described in PA. The new GTF2I-BRAF 19-10 fusion was found in one case, while the other five cases harbored the frequent KIAA1549-BRAF 16-9 fusion gene. Similar to other BRAF fusions, the GTF2I-BRAF fusion retains an intact BRAF kinase domain while the inhibitory N-terminal domain is lost. Functional studies on GTF2I-BRAF showed elevated MAPK pathway activation compared to BRAFWT. Comparing fusion detection methods, we found Fluorescence in situ hybridization with BRAF break apart probe as the most sensitive method for detection of different BRAF rearrangements (GTF2I-BRAF and KIAA1549-BRAF). Our finding of a new BRAF fusion in PA further emphasis the important role of B-Raf in tumorigenesis of these tumor types. Moreover, the consistency and growing list of BRAF/RAF gene fusions suggests these rearrangements to be informative tumor markers in molecular diagnostics, which could guide future treatment strategies."],"pubmed_title":["A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma."],"pubmed_authors":["Tomić Tajana Tešan TT, Olausson Josefin J, Wilzén Annica A, Sabel Magnus M, Truvé Katarina K, Sjögren Helene H, Dósa Sándor S, Tisell Magnus M, Lannering Birgitta B, Enlund Fredrik F, Martinsson Tommy T, Åman Pierre P, Abel Frida F"],"name_synonyms":["Vasp, VASP, Data Set., DmelCG15112, ENHANCER OF ATNSI ACTIVITY, MENA, NDPP1, l(2)02029, Enb, enb, ENA, Ena, CG15112, ENA/VASP"],"pubmed_title_synonyms":["glycogen synthase kinase activity, DIWS, DmErk, extracellular signal-regulated kinase activity, pp44mapk, protein kinase A activity, Mpk2, p42mapk, Astrocytomas, Prp4 protein kinase activity, Grade I Astrocytomas, SR2-1, LeMPK3, Subependymal Giant Cell Astrocytoma, Grade II Astrocytomas, ATP-protein transphosphorylase activity, p44mpk, Cerebral Astrocytoma, ATP:protein phosphotransferase (non-specific) activity, kinase-related transforming protein, Dp38, Pilocytic Astrocytoma, AA120551, mitogen-activated protein kinase activity, SAPK2, mpk1, SEM, Sem, Gemistocytic Astrocytoma, Piloid astrocytoma, MAP-k, Spin, Erk/Map kinase, pp42, DERK-A, Dsor2, E(sina)7, benign, sem, Rl, Raf kinase activity, Astrocytoma, 9930012E13Rik, Fibrillary, SPIN, MP kinase activity, serine kinase activity, DERK, C230098H17, atypical protein kinase C activity, BTKAP1, Diws1t, grade I astrocytic tumour, Astroglioma, MBP kinase II activity, Protoplasmic Astrocytomas, mitogen-activated S6 kinase activity, protein-aspartyl kinase activity, dERK, D6Ertd631e, GTFII-I, 6030441I21Rik, ERK-A, p82 kinase activity, B-RAF1, MAP kinase 2 activity, dpERK, dpErk, Pilocytic, Mapk, Cerebral Astrocytomas, Oligoastrocytoma, betaIIPKC, Astrocytic, Erk1, ERK1, ERK2, mapk1a, DmMAPK, PMK-2, dp-ERK, PMK-1, BAP135, Anaplastic, PMK-3, M phase-specific cdc2 kinase activity, Wee-kinase activity, grade I astrocytic neoplasm, mapk1b, MapK, MAPK, grade I astrocytoma, pMAPK, pMapK, BAP-135, Gliomas, serine protein kinase activity, Mixed Oligoastrocytomas, erk2, mapk, activation, Grade I Astrocytoma, ERKa, phosphorylase B kinase kinase activity, RAFB1, DmERKA, Gemistocytic Astrocytomas, rl/MAPK, BcDNA:RE08694, Anaplastic Astrocytoma, protein glutamyl kinase activity, l(2R)EMS45-39, AA387315, DmelCG12559, Childhood Cerebral, non-specific serine/threonine protein kinase activity, p38, Grade III Astrocytomas, l(2)41Ac, Protoplasmic Astrocytoma, GtfII-I, DpErk, DpERK, Intracranial, ErkA, ERKA, hydroxyalkyl-protein kinase activity, CT34260, WEE1Hu, dpERk, WBS, serine-specific protein kinase activity, epsilon PKC, SAPK, HIPK2, Subependymal Giant Cell, cytidine 3', Glioma, Wee 1-like kinase activity, Fibrillary Astrocytomas, Protoplasmic, AA473386, pERK, ribosomal S6 protein kinase activity, calcium/phospholipid-dependent protein kinase activity, Grade II, glycogen synthase A kinase activity, GroupII, Grade II Astrocytoma, glycogen synthase kinase 3 activity, 12559, NS7, TFII-I, phosphorylase b kinase kinase activity, pilocytic, EK2-1, Pleomorphic Xanthoastrocytomas, Astrocytic Gliomas., IB291, serine(threonine) protein kinase activity, ribosomal protein S6 kinase II activity, Cerebral, Juvenile Pilocytic Astrocytoma, Erk, ERK, T-antigen kinase activity, PRKM1, galactosyltransferase-associated kinase activity, PRKM2, protein-serine kinase activity, xp42, STK32, Intracranial Astrocytoma, C87398, Childhood Cerebral Astrocytomas, astrocytoma, p42 mitogen-activated protein kinase activity, Anaplastic Astrocytomas, CG18732, ATP:protein phosphotransferase (MAPKK-activated) activity, Juvenile Pilocytic, erk, Gemistocytic, Grade III Astrocytoma, protein kinase (phosphorylating) activity, protein-cysteine kinase activity, Raf-1, Xanthoastrocytoma, Hpr kinase activity, rll, DmERK-A, STK26, p38-2, casein kinase (phosphorylating) activity, myelin basic protein kinase activity, Pilocytic Astrocytomas, Grade III, WBSCR6, Childhood Cerebral Astrocytoma, ert1, prkm2, stress-activated kinase activity, prkm1, CT39192, MAP-2 kinase activity, BRAF1, Astrogliomas, protein serine kinase activity, Juvenile Pilocytic Astrocytomas, Pleomorphic, protein phosphokinase activity, Juvenile, p38delta, twitchin kinase activity, pilocytic astrocytoma, PKA, PKC, stress-activated protein kinase activity, mapk2, AP50 kinase activity, mapk1, MBP kinase I activity, Pleomorphic Xanthoastrocytoma, B-raf, Mixed, protein kinase p58 activity, Xp42, serine/threonine protein kinase activity, threonine-specific protein kinase activity, CG12559, Grade I, Gtf2ird1, mitogen activated kinase activity, Su(Raf)2B, dpERK1, Intracranial Astrocytomas, Astrocytic Glioma, EY2-2, Childhood, dsk1, 5'-cyclic monophosphate-responsive protein kinase activity, atypical PKC activity, D-ERK, Braf-2, dpMAPK, Braf2, Mixed Oligoastrocytoma, Fibrillary Astrocytoma, protein serine-threonine kinase activity, SAP kinase activity, grade I astrocytic tumor, MAP kinase 1 activity, A-kinase activity"],"description_synonyms":["glycogen synthase kinase activity, DIWS, APR, DmErk, extracellular signal-regulated kinase activity, pp44mapk, protein kinase A activity, RNA Sequence Determination, Sequence Determination, Mpk2, RNA Sequence, p42mapk, Tumor, Astrocytomas, Grade I Astrocytomas, Prp4 protein kinase activity, SR2-1, Subependymal Giant Cell Astrocytoma, LeMPK3, Grade II Astrocytomas, ATP-protein transphosphorylase activity, p44mpk, Cerebral Astrocytoma, ATP:protein phosphotransferase (non-specific) activity, kinase-related transforming protein, Pilocytic Astrocytoma, Dp38, AA120551, mitogen-activated protein kinase activity, Analysis, SAPK2, mpk1, SEM, Sem, Gemistocytic Astrocytoma, Piloid astrocytoma, MAP-k, Spin, Erk/Map kinase, Analyses, pp42, Determination, NOXA, DERK-A, Dsor2, benign, E(sina)7, sem, Rl, Sequence Determinations, Astrocytoma, Raf kinase activity, 9930012E13Rik, Fibrillary, SPIN, MP kinase activity, serine kinase activity, DERK, C230098H17, atypical protein kinase C activity, BTKAP1, Diws1t, LRP1A., grade I astrocytic tumour, Astroglioma, Protoplasmic Astrocytomas, MBP kinase II activity, mitogen-activated S6 kinase activity, protein-aspartyl kinase activity, Malignancies, dERK, D6Ertd631e, GTFII-I, Tumors, 6030441I21Rik, ERK-A, p82 kinase activity, B-RAF1, MAP kinase 2 activity, dpERK, dpErk, Pilocytic, Papers, Cerebral Astrocytomas, Oligoastrocytoma, Mapk, Astrocytic, betaIIPKC, Erk1, ERK1, ERK2, mapk1a, DmMAPK, PMK-2, dp-ERK, PMK-1, BAP135, Anaplastic, Determinations, PMK-3, M phase-specific cdc2 kinase activity, Wee-kinase activity, grade I astrocytic neoplasm, Benign, mapk1b, MapK, grade I astrocytoma, MAPK, pMAPK, pMapK, Gliomas, BAP-135, Mixed Oligoastrocytomas, serine protein kinase activity, erk2, mapk, activation, Grade I Astrocytoma, ERKa, phosphorylase B kinase kinase activity, RAFB1, DmERKA, Gemistocytic Astrocytomas, Anaplastic Astrocytoma, rl/MAPK, BcDNA:RE08694, protein glutamyl kinase activity, l(2R)EMS45-39, Childhood Cerebral, AA387315, DmelCG12559, non-specific serine/threonine protein kinase activity, Benign Neoplasms, Grade III Astrocytomas, p38, l(2)41Ac, Protoplasmic Astrocytoma, GtfII-I, Malignant Neoplasms, DpErk, DpERK, Intracranial, ErkA, ERKA, hydroxyalkyl-protein kinase activity, CT34260, WEE1Hu, dpERk, WBS, serine-specific protein kinase activity, epsilon PKC, Subependymal Giant Cell, SAPK, HIPK2, cytidine 3', Glioma, other neoplasm, Fibrillary Astrocytomas, Wee 1-like kinase activity, Protoplasmic, AA473386, pERK, IGFBP3R, ribosomal S6 protein kinase activity, calcium/phospholipid-dependent protein kinase activity, Grade II, glycogen synthase A kinase activity, Grade II Astrocytoma, GroupII, Neoplasms, glycogen synthase kinase 3 activity, Benign Neoplasm, 12559, NS7, APOER, Malignant, TFII-I, phosphorylase b kinase kinase activity, pilocytic, EK2-1, Pleomorphic Xanthoastrocytomas, CD91, IB291, serine(threonine) protein kinase activity, ribosomal protein S6 kinase II activity, Cerebral, Juvenile Pilocytic Astrocytoma, Erk, ERK, T-antigen kinase activity, PRKM1, galactosyltransferase-associated kinase activity, PRKM2, protein-serine kinase activity, Malignancy, xp42, STK32, Intracranial Astrocytoma, Childhood Cerebral Astrocytomas, C87398, astrocytoma, Anaplastic Astrocytomas, p42 mitogen-activated protein kinase activity, Sequencing, CG18732, Juvenile Pilocytic, ATP:protein phosphotransferase (MAPKK-activated) activity, erk, Neoplasias, Gemistocytic, Grade III Astrocytoma, protein kinase (phosphorylating) activity, protein-cysteine kinase activity, A2MR, RNA Sequence Analyses, Raf-1, Xanthoastrocytoma, Hpr kinase activity, RNA Sequencing, rll, DmERK-A, STK26, p38-2, casein kinase (phosphorylating) activity, myelin basic protein kinase activity, Sequence Analyses, Cancer, Astrocytic Gliomas, Pilocytic Astrocytomas, Grade III, Childhood Cerebral Astrocytoma, WBSCR6, RNA, ert1, Malignant Neoplasm, LRP, RNA Sequence Determinations, prkm2, stress-activated kinase activity, prkm1, CT39192, MAP-2 kinase activity, BRAF1, Astrogliomas, Juvenile Pilocytic Astrocytomas, protein serine kinase activity, Pleomorphic, protein phosphokinase activity, Juvenile, p38delta, twitchin kinase activity, pilocytic astrocytoma, PKA, PKC, stress-activated protein kinase activity, mapk2, AP50 kinase activity, mapk1, Neoplasm, Pleomorphic Xanthoastrocytoma, MBP kinase I activity, TGFBR5, B-raf, Mixed, protein kinase p58 activity, Xp42, serine/threonine protein kinase activity, threonine-specific protein kinase activity, CG12559, Grade I, Gtf2ird1, mitogen activated kinase activity, Su(Raf)2B, dpERK1, Intracranial Astrocytomas, Astrocytic Glioma, EY2-2, Cancers, Childhood, dsk1, 5'-cyclic monophosphate-responsive protein kinase activity, atypical PKC activity, D-ERK, Braf-2, dpMAPK, Braf2, Mixed Oligoastrocytoma, RNA Sequence Analysis, Fibrillary Astrocytoma, protein serine-threonine kinase activity, Neoplasia, grade I astrocytic tumor, SAP kinase activity, MAP kinase 1 activity, A-kinase activity"],"pubmed_abstract_synonyms":["clr8, DmErk, extracellular signal-regulated kinase activity, pp44mapk, Materials, RNA Sequence Determination, Sequence Determination, Brain Neoplasms, RNA Sequence, raf, growth and development, Tumor, Brain Metastases, Grade I Astrocytomas, Prp4 protein kinase activity, Mutations, Subependymal Giant Cell Astrocytoma, LeMPK3, INTRACRANIAL NEOPL, ATP-protein transphosphorylase activity, Method, p44mpk, Cerebral Astrocytoma, ATP:protein phosphotransferase (non-specific) activity, Pilocytic Astrocytoma, Dp38, 1, AA120551, Kinase, Analysis, tumour of brain, SAPK2, SEM, Sem, Piloid astrocytoma, MAP-k, treatment, Spin, brain neoplasms, pp42, Draf-1, Analyses, Molecular, Brain Malignant Neoplasms, Dsor2, Brain Tumor, procedures, elevated, sem, D-raf1, Sequence Determinations, B-Raf, HYPT11, Astrocytoma, ISH, allergic reaction, Fibrillary, SPIN, high frequency, Brain Neoplasm, BTKAP1, Role Concepts, grade I astrocytic tumour, Protoplasmic Astrocytomas, ATP Phosphotransferases, GTFII-I, Tumors, Diagnostic Findings, ERK-A, p82 kinase activity, 6030441I21Rik, Diagnostic Molecular Pathologies, Intracranial Neoplasm, brain neoplasm, dpERK, dpErk, Pilocytic, Malignant Brain Neoplasms, l(1)phl, Brain Benign Neoplasm, Cerebral Astrocytomas, betaIIPKC, familial, Molecular Diagnostic, DmMAPK, Primary Brain Neoplasm, PMK-2, dp-ERK, PMK-1, Procedure, BAP135, Anaplastic, Primary Brain Tumor, PMK-3, Wee-kinase activity, Benign, bis(2-chloroethyl)sulfane, Role Concept, Brain Malignant Neoplasm, Role, pMAPK, pMapK, EAR-1, Pathology, v-Raf, BAP-135, Mixed Oligoastrocytomas, activation, Malignant Brain Neoplasm, Grade I Astrocytoma, Primary Malignant, DmERKA, Gemistocytic Astrocytomas, l(1)pole hole, rl/MAPK, CRAF, non-specific serine/threonine protein kinase activity, Grade III Astrocytomas, Benign Neoplasms, l(2)41Ac, INSDC_feature:gene, Methodological, l(1)polehole, GtfII-I, D-raf, Malignant Neoplasms, CT34260, CMD1NN, neoplasm of the brain, dpERk, ECP 1, Material, serine-specific protein kinase activity, Subependymal Giant Cell, SAPK, HIPK2, cytidine 3', Glioma, Afr-1, EG:BACH48C10.3, BB129353, Wee 1-like kinase activity, other neoplasm, Clinical Finding, Protoplasmic, AA473386, Brain, Brain Tumors, glycogen synthase A kinase activity, Grade II Astrocytoma, Neoplasms, glycogen synthase kinase 3 activity, Diagnostic Molecular Pathology, 12559, DRaf, protein-containing complex, AFR1, Afr1, draf, phosphorylase b kinase kinase activity, pilocytic, EK2-1, Pleomorphic Xanthoastrocytomas, Recurrent Brain Tumors, SME, sensitive, Gene Products, Molecular Pathology, ribosomal protein S6 kinase II activity, Juvenile Pilocytic Astrocytoma, Technique, D-RAF, D-Raf, Erk, ERK, PRKM1, PRKM2, protein-serine kinase activity, mKIAA0854, Diagnostic, sme, STK32, C87398, Phl, b-raf, Sequencing, erk, bis(2-chloroethyl) sulphide, Gemistocytic, Neoplasias, Study, protein-cysteine kinase activity, Xanthoastrocytoma, Hpr kinase activity, rll, Draf, STK26, p38-2, constitutitional genetic, high elevation, myelin basic protein kinase activity, NEOPL INTRACRANIAL, Cancer, Sequence Analyses, Pilocytic Astrocytomas, WBSCR6, RNA, sm-e, Malignant Neoplasm, 1-chloro-2-[(2-chloroethyl)thio]ethane, RNA Sequence Determinations, raf-1, Proteins, stress-activated kinase activity, MAP-2 kinase activity, Point Mutations, BRAF1, Sm-E, Primary, protein serine kinase activity, nev, protein phosphokinase activity, Concept, disease management., PKA, native protein, PKC, stress-activated protein kinase activity, mapk2, chemical analysis, mapk1, Neoplasm, AA990557, Mitogen, Mutation, protein kinase p58 activity, serine/threonine protein kinase activity, brain neoplasm (disease), CG12559, Grade I, Gtf2ird1, dpERK1, Intracranial Astrocytomas, postnatal growth, Childhood, Cancers, dsk1, 5'-cyclic monophosphate-responsive protein kinase activity, atypical PKC activity, Phytomitogens, plan specification, l(1)polehole/draf, Gene Proteins, dpMAPK, Braf2, Mixed Oligoastrocytoma, Point, Isolation of Nuclei TAgged in specific Cell Types, Fusions, Benign Brain Neoplasm, R14, brain tumour, R15, Fibrillary Astrocytoma, ph, hereditary, protein serine-threonine kinase activity, SAP kinase activity, Neoplasia, glycogen synthase kinase activity, DIWS, c-Raf, protein kinase A activity, single-organism developmental process, determination, Mpk2, postnatal development, p42mapk, Molecular Diagnostics, protein, Molecular Pathologies, Astrocytomas, SR2-1, R5, Techniques, Grade II Astrocytomas, Roles, kinase-related transforming protein, Concepts, mitogen-activated protein kinase activity, In Situ, cmc1, protein aggregate, mpk1, Fusion, Gemistocytic Astrocytoma, in situ hybridization, Erk/Map kinase, Determination, mKIAA1549, Iprit, DERK-A, Primary Brain Tumors, benign, E(sina)7, Craf1, Rl, Raf kinase activity, 9930012E13Rik, genetic, MP kinase activity, serine kinase activity, DERK, CG14648, neoplasm of brain, C230098H17, Methodological Studies, Primary Malignant Brain Tumors, atypical protein kinase C activity, Diws1t, Recurrent Brain Tumor, mustard gas, Pathologies, Astroglioma, disease management, MBP kinase II activity, Therapies, mitogen-activated S6 kinase activity, protein-aspartyl kinase activity, dERK, Malignancies, D6Ertd631e, ATP, Therapy, SIGNS SYMPTOMS, 6430402F14Rik, MAP kinase 2 activity, B-RAF1, Growl, Oligoastrocytoma, Mapk, Hybridization, DESC, Astrocytic, KIAA0854, Malignant Primary Brain Neoplasms, Erk1, ERK1, ERK2, mapk1a, copy number variation, NEOPL BRAIN, Hybridizations, Kiaa1549, Determinations, M phase-specific cdc2 kinase activity, ZHX2, grade I astrocytic neoplasm, Brain Benign Neoplasms, mapk1b, MapK, grade I astrocytoma, MAPK, Gene Fusions, Malignant Primary Brain Tumors, Genetic Materials, Gliomas, serine protein kinase activity, DRaf1, erk2, mapk, Genetic Material, l(1)G0475, Transphosphorylases, ERKa, phosphorylase B kinase kinase activity, RAFB1, Diagnostics, Anaplastic Astrocytoma, BcDNA:RE08694, protein glutamyl kinase activity, Cancer of the Brain, l(2R)EMS45-39, Draf1, raf1, Diagnostic Molecular, Childhood Cerebral, DmelCG12559, AA387315, common, p38, Protoplasmic Astrocytoma, tumor of the Brain, Methodological Study, Treatments, DpErk, DpERK, Intracranial, ErkA, ERKA, hydroxyalkyl-protein kinase activity, WEE1Hu, brain tumor, WBS, epsilon PKC, C110, Cistron, inherited genetic, Fibrillary Astrocytomas, pERK, rafl, ribosomal S6 protein kinase activity, calcium/phospholipid-dependent protein kinase activity, Grade II, Primary Malignant Brain Neoplasms, Procedures, GroupII, Primary Brain Neoplasms, Cancer of Brain, Benign Neoplasm, NS5, NS7, Gene, Yperite, Malignant, TFII-I, Symptoms and Signs, method, Recurrent, method used in an experiment, Phytomitogen, Studies, serine(threonine) protein kinase activity, IB291, Mustard gas, Finding, 1'-thiobis(2-chloroethane), Cerebral, Phosphotransferase, sensitivity, Raf1, T-antigen kinase activity, galactosyltransferase-associated kinase activity, study, Genetic, tumour of the Brain, DmelCG2845, Malignancy, xp42, anon-WO0118547.126, Intracranial Astrocytoma, Childhood Cerebral Astrocytomas, astrocytoma, Hybridization in Situ, Transphosphorylase, growl, Anaplastic Astrocytomas, p42 mitogen-activated protein kinase activity, CG18732, Juvenile Pilocytic, ATP:protein phosphotransferase (MAPKK-activated) activity, Lost, Grade III Astrocytoma, protein kinase (phosphorylating) activity, PRIMARY BRAIN NEOPL, RNA Sequence Analyses, Raf-1, l(1)raf, RNA Sequencing, DmERK-A, In Situ Hybridizations, DmelCG14648, genomic copy number variation, casein kinase (phosphorylating) activity, tumor of brain, sulfur mustard, Astrocytic Gliomas, Grade III, Childhood Cerebral Astrocytoma, ert1, protein complex, Benign Brain Neoplasms, prkm2, prkm1, CT39192, l(1)2Fe, Astrogliomas, Juvenile Pilocytic Astrocytomas, Cistrons, Pleomorphic, Phosphotransferases, Ear4, Juvenile, p38delta, development, Signs and Symptoms, twitchin kinase activity, Raf/phl, pilocytic astrocytoma, Protein, AP50 kinase activity, Pleomorphic Xanthoastrocytoma, MBP kinase I activity, Brain Cancers, B-raf, Mixed, techniques, Brain Metastase, Xp42, Intracranial Neoplasms, threonine-specific protein kinase activity, dos1, frequent, Kinases, mitogen activated kinase activity, Su(Raf)2B, Senfgas, Astrocytic Glioma, EY2-2, l(1)ph, Brain Cancer, 11-29, Protein Gene Products, D-ERK, D830050J10Rik, Braf-2, Therapeutic, RNA Sequence Analysis, Treatment, assay, RAF, Raf, growth, grade I astrocytic tumor, MAP kinase 1 activity, A-kinase activity, methodology, CG2845"],"additional_accession":[]},"is_claimable":false,"name":"ena-DATASET-CGNT-13-01-2017-11:31:00:793-49 - samples","description":"Total stranded TruSeq RNA sequencing by Illumina of six tumor samples from six cases of pediatric Pilocytic astrocytoma. The data is published in the following paper: Tomic TT, Olausson J, Wilzen A, Sabel M, Truve K, Sjogren H, Dosa S, Tisell M, Lannering B, Enlund F, Martinsson T, Aman P, Abel F. A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma. PLoS One. 2017 Apr 27;12(4):e0175638.","dates":{"updated":"2017-07-26 15:39:29"},"accession":"EGAD00001003143","cross_references":{"TAXONOMY":["9606"],"pubmed":["28448514"],"EGA":["EGAC00001000572","EGAS00001002149"]}}