EGAGenomicsIllumina HiSeq 2000;ILLUMINAhttps://ega-archive.org/datasets/EGAD0000100336249EGA dataset EGAD00001003362EGAColorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.Schütte Moritz M, Risch Thomas T, Abdavi-Azar Nilofar N, Boehnke Karsten K, Schumacher Dirk D, Keil Marlen M, Yildiriman Reha R, Jandrasits Christine C, Borodina Tatiana T, Amstislavskiy Vyacheslav V, Worth Catherine L CL, Schweiger Caroline C, Liebs Sandra S, Lange Martin M, Warnatz Hans-Jörg HJ, Butcher Lee M LM, Barrett James E JE, Sultan Marc M, Wierling Christoph C, Golob-Schwarzl Nicole N, Lax Sigurd S, Uranitsch Stefan S, Becker Michael M, Welte Yvonne Y, Regan Joseph Lewis JL, Silvestrov Maxine M, Kehler Inge I, Fusi Alberto A, Kessler Thomas T, Herwig Ralf R, Landegren Ulf U, Wienke Dirk D, Nilsson Mats M, Velasco Juan A JA, Garin-Chesa Pilar P, Reinhard Christoph C, Beck Stephan S, Schäfer Reinhold R, Regenbrecht Christian R A CR, Henderson David D, Lange Bodo B, Haybaeck Johannes J, Keilholz Ulrich U, Hoffmann Jens J, Lehrach Hans H, Yaspo Marie-Laure MLfalseena-DATASET-MPIMG-15-06-2017-11:13:21:311-1353 - samplesRNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer primary tumor sample (EPO2_cohort)2017-07-26 15:39:30EGAD00001003362960628186126EGAC00001000469EGAS00001001752