{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["N/A"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001005018"],"sample_count":["2"],"description":["EGA dataset EGAD00001005018"],"repository":["EGA"],"title":["MultiOMICS study of a pair of infant monozygotic twins with concordant B-cell ALL (WGBS)"],"additional_accession":[]},"is_claimable":false,"name":"e0dec848-609c-4d16-b78a-6e986b5a29ce - samples","description":"B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common cancer in childhood. Studying identical twins with B-cell ALL provides a unique and tractable model for deciphering the developmental timing of pre- and post-natal mutations contributing to clonal evolution. To date, this has mainly focused on major cytogenetic subgroups of childhood B-cell ALL, including MLL fusions, ETV6-RUNX1, hyperdiploidy, and BCR-ABL1. However, formal demonstration of the prenatal origin and “backtracking” the natural history of the leukemia remains understudied in “B-other”/Normal Karyotype (NK) B-cell ALL. To characterize the epigenetic landscape of this particular leukemia subtype, we performed DNA bisulfite-sequencing on a pair of 8-month-old monozygotic twins diagnosed with concordant “B-other”/NK B-cell ALL.","dates":{"updated":"2020-07-16 15:33:08"},"accession":"EGAD00001005018","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAC00001001202","EGAS00001003651"]}}