{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["N/A"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001005949"],"sample_count":["39"],"description":["EGA dataset EGAD00001005949"],"repository":["EGA"],"title":["RNAseq data from the study - Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML"],"name_synonyms":["Vasp, VASP, 633., DmelCG15112, ENHANCER OF ATNSI ACTIVITY, RCB2352, Data Set, MENA, NDPP1, l(2)02029, Enb, enb, ENA, Ena, CG15112, ENA/VASP"],"description_synonyms":["cytarabine, Materials, RNA Sequence Determination, Activity, acute non lymphoblastic leukemia, Myeloid, Laboratory, Sequence Determination, Blood, RNA Sequence, 4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2, Xkl-1, 3-b)pyridin-5-yloxy)benzamide, Agreements, Aracytine, KL receptor activity, Gsfsco1, responsivity, Cytosar-U, Ara-C, SCO5, SCO1, citarabina, Analysis, Research Activity, Transfer, Gsfsow3, Laboratory Research, Gsfsco5, Non Polyadenylated, 4-amino-1-beta-D-arabinofuranosyl-, SOW3, Priorities, haematopoietic cell, thymus nucleic acid, me75, Analyses, Genomes, Determination, Acute Myeloblastic Leukemia, Polyadenylated Messenger, haemopoietic cell, cytarabinum, nucleic acid library preparation, W, amlcr1, Venclexta, Sequence Determinations, aml1, D17Mit170, T1, Cytosine-1-beta-D-arabinofuranoside, XAML, set, Bs, Agreement, ANLL, Double-Stranded DNA, deoxyribonucleic acids, Arabinosylcytosine, Research Priority, DNAn, Sl, acute myelogenous, hemopoietic cell, 4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2, Polyadenylated, Arabinoside, Aracytidine, Research Priorities, Tr-kit, Double-Stranded, Arabinofuranosylcytosine, Tl3, Cytosine, Tl2, Determinations, (Deoxyribonucleotide)n+m, PBT, batch, count, Blood Corpuscle., kl1-A, Corpuscles, Genetic Materials, KIT, desoxyribose nucleic acid, evi-1, 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone, Cytonal, Genetic Material, Research and Development, Polyadenylated Messenger RNA, tyrosine-protein kinase Kit, Acute myelogenous leukemia, 2(1H)-Pyrimidinone, RG-7601, beta-Ara C, pbt, Blood Cell, Non Polyadenylated mRNA, GDC-0199, protein_coding_transcript, Myeloblastic, susceptibility to, Acute Myeloid Leukemia, 4-(4-((2-(4-chlorophenyl)-4, arabinocytosine, INSDC_feature:gene, whole genome, kit, 3-b)pyridin-5-yloxy)-, Non-Polyadenylated mRNA, Activities, Corpuscle, beta Ara C, Patient, Material, aml-1, ds DNA, Cells, Cistron, Cytosine Arabinoside, Blood Corpuscles, DNA, Poly(A) RNA, Gruppe, krk1, DNS, (Deoxyribonucleotide)n, SCF receptor activity, Gene, Deoxyribonucleic acids, Cytosine arabinoside, acute non lymphoblastic leukaemia, Deoxyribonucleic Acid, scfr, Publication, Messenger, acute myeloid, Low, RG7601, SCFR, Runx-1, study, reactivity, Fdc, Leukemia, Genetic, Research, nucleic acid library construction, Double Stranded, messenger RNA, Deoxyribonucleic acid, pebp2ab, Sequencing, ABT-199, template RNA, RNA Sequence Analyses, grupos, Clients, RNA Sequencing, (Deoxyribonucleotide)m, Development and Research, Sequence Analyses, disease remission, leukemia, proto-oncogene c-Kit, RNA, cou, grupo, ara-C, RNA Sequence Determinations, DNAn+1, Messenger RNA, Ara C, Cistrons, Client, Cell, group, AML, benzamide, Lr, Priority, KIT ligand receptor activity, Poly(A)+ mRNA, Research Activities, INSDC_feature:mRNA, cytosine-beta-D-arabinofuranoside, Polyadenylated RNA, aml1-evi-1, ds-DNA, cbfa2, Library, Cytosar U, XKrk1, blood cell, aml, Cytarabine Hydrochloride, c-KIT, Poly(A)+ RNA, ensemble, mRNA, Poly(A) Tail, library construction, Xaml1, Arabinoside C, Rest, Non-Polyadenylated, CD117, Cytosar, 1-beta-D-Arabinofuranosylcytosine, c-kit, Acute, C-Kit, Ssm, RNA Sequence Analysis, Desoxyribonukleinsaeure, Bra, xkl-1, Transfer Agreements, response, Polyadenylated mRNA, groupe"],"additional_accession":[]},"is_claimable":false,"name":"ena-DATASET-WEHI-07-02-2020-01:38:15:633-48 - samples","description":"This study assessed molecular determinants of response in a cohort of patients with AML that were treated with venetoclax in combination with either DNA methyltransferase inhibitors or low dose cytarabine. RNA sequencing was performed on 31 patients from three different response classes [10 Group A - Durable remission (n=10), Group B - Relapsed (n=10) and Group C - Refractory (n=11)]. Library preparation and sequencing was performed at the Australian Genome Research Facility, using the Truseq Stranded mRNA library kit. Technical and batch replicate samples are included. Gene count data are provided with the original publication. The use of the sequencing data is subject to a data transfer agreement and is restricted to ethically approved research into blood cell malignancies and cannot be used to assess germline variants.","dates":{"updated":"2020-02-28 11:53:53"},"accession":"EGAD00001005949","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAC00001001461","EGAS00001003820"]}}