RNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controls

EGAGenomicsN/Ahttps://ega-archive.org/datasets/EGAD00001005973297EGA dataset EGAD00001005973EGARNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controlsfalsef3506e87-4bfc-4be6-b070-ecd8d69441b7 - samplesWe are interested in inter-individual variation in transcriptional response to immune checkpoint blockade. We have analysed poly A purified RNA expression from CD8 T cells (297 transcriptomes in total) isolated from metastatic melanoma patients (n=106) prior to and during treatment with either single agent (Pembrolizumab) or combination (Ipilimumab/ Nivolumab) immune checkpoint blockade. We compare expression at different stages of treatment and additionally contrast this with that from healthy controls (n=68).2020-04-21 17:51:39EGAD000010059739606EGAC00001001482EGAS00001004081