{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["N/A"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001006305"],"sample_count":["82"],"description":["EGA dataset EGAD00001006305"],"repository":["EGA"],"title":["The Transcriptional Landscape of SHH Medulloblastoma"],"name_synonyms":["ribonucleic acid, Acid, xshh, RNA, Ribonucleic, HLP3, ShhNC, ribose nucleic acid, Sonic hedgehog protein C-product, MCOPCB5, Non Polyadenylated RNA, ribonucleic acids, SHH, Sonic hedgehog protein 27 kDa product, Non-Polyadenylated, RNA-seq, Hxl3, Papers., RNS, Ribonucleic Acid, Dsh, TPT, Xhh, TPTPS, Non-Polyadenylated RNA, Hhg1, Magics, HHG1, SMMCI, yeast nucleic acid, Sonic hedgehog protein 19 kDa product, Ribonukleinsaeure, Sonic hedgehog protein N-product, Hx, Gene Products, Whole Transcriptome Shotgun Sequencing, pentosenucleic acids, HHG-1, hedgehog, Ribonucleic acids, HPE3, Non Polyadenylated, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, 9530036O11Rik, M100081, RNA Gene Products"],"description_synonyms":["tuf, Materials, hN-CoR, RNA Sequence Determination, tumor suppressor, FALL39, 5'-cyclic monophosphate, PTCH11, A230020K14Rik, Sequence Determination, RNA Sequence, cerebellar medulloblastoma, mycna, CG2411, positive regulation by symbiont of host non-apoptotic programmed cell death, mycnb, desmoplastic, Tumor, A230106A15Rik, CPNET, cell cycle regulator, Circumscribed Arachnoidal, CAP-18, Medullomyoblastomas, pathogenesis, Medulloblastoma, Analysis, infratentorial primitive neuroectodermal tumour, Desmoplastic Medulloblastomas, C13orf8, Medulloblastomas, Man (Taxonomy), stimulation by symbiont of host programmed cell death, Analyses, Determination, b2b273Clo, MCOPCB5, cAMP, ZNF828, 3', Hxl3, Nmyc1, Adult Medulloblastomas, 5730405M06Rik, Adult, Melanocytic Medulloblastomas, N-myc, Sequence Determinations, genetic, Sarcoma, childhood, PPP1R109, XN-myc, SMMCI, Sonic hedgehog protein 19 kDa product, Malignancies, Nucleotide, Desmoplastic Medulloblastoma., N-CoR1, RIP13, Tumors, HSD26, sufu, localized primitive neuroectodermal tumor, Sonic hedgehog protein C-product, Modern, familial, SHH, SUFU, CAP18, CNS PNET, 5'-phosphate, CAMP, Determinations, pat, Benign, DmelCG2411, Cyclic AMP, Rxrip13, modulation by symbiont of host system process, Genetic Materials, PRO1280, Cerebellar, Genetic Material, nucleotides, Desmoplastic Medulloblastoma, PTC, Ptc, xN-myc1, Circumscribed, CHAMP, Benign Neoplasms, SuFu, INSDC_feature:gene, human, Malignant Neoplasms, Material, activation by symbiont of host programmed cell death, Sonic hedgehog protein N-product, Adenosine 3', Childhood Medulloblastoma, Cistron, inherited genetic, Sufu, adenosine 3', 9530036O11Rik, com4, xshh, CRAMP, human being, Nmyc, Neoplasms, SUFUH, regulation by symbiont of host system process, Arachnoidal Cerebellar Sarcoma, ODED, Benign Neoplasm, number, Gene, SUFUXL, mKIAA1047, SU(FU), Malignant, presence, Human, 5'-Cyclic AMP, mycn, N-CoR, Homo sapiens, Cyclic adenylic acid, induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction, NMYC, Hx, HHG-1, hedgehog, nmyc, Man, Ptc_Dm, Genetic, ShhNC, Malignancy, PTCH, Su(Fu), Ptch2, BcDNA:RH36596, causes, TPT, Xhh, Nmuc1, Sequencing, ptch, Neoplasias, MODED, Conf, RNA Sequence Analyses, CG6054, causality, RNA Sequencing, Ptc1, bHLHe37, PTC1, constitutitional genetic, Childhood Medulloblastomas, XNmyc, Sequence Analyses, Cancer, RNA, activation by organism of non-apoptotic programmed cell death in other organism, Malignant Neoplasm, MDB, hemolysin activity, RNA Sequence Determinations, Sonic hedgehog protein 27 kDa product, 2810026F04Rik, function, Dsh, medulloblastoma with extensive nodularity, Cistrons, Melanocytic, TPTPS, count in organism, medulloblastoma, 5'-cyclic phosphate, c-nmyc, Ptch, Neoplasm, core, Su(fu), su(fu), HPE3, HPE7, l(2)k02507, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, M100081, DmelCG6054, HLP3, LL37, FALL-39, Desmoplastic, TRAC1, 5'-(hydrogen phosphate), NBCCS, Childhood, Cancers, Adult Medulloblastoma, BCNS, mes, localised primitive neuroectodermal tumour, 5'-CYCLIC-MONOPHOSPHATE, Nmyc-1, infratentorial primitive neuroectodermal tumor, Medullomyoblastoma, rubr, Hhg1, HHG1, Modern Man, RNA Sequence Analysis, cardinality, ADENOSINE-3', dPtc, hereditary, Neoplasia, Melanocytic Medulloblastoma"],"additional_accession":[]},"is_claimable":false,"name":"MAGIC_RNA-Seq_MB_samples_SHH_RNA_seq_paper - samples","description":"To further understand the biology of Sonic hedgehog medulloblastoma and its molecular subtypes, we studied 250 human Shh-MB using strand-specific RNA sequencing. We identified novel alterations within the cAMP dependent pathway and found that 18% of tumors have genetic events that directly target the abundance and/or stability of MYCN. We also discovered an extensive network of fusions in focally amplified regions, and several loss-of-function fusions in tumor suppressor genes PTCH, SUFU and NCOR1. Molecular convergence on a core of specific genes by nucleotide variants, copy number aberrations, and gene fusions highlights key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma.","dates":{"updated":"2020-12-21 16:25:04"},"accession":"EGAD00001006305","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAC00001001002","EGAS00001000273"]}}