{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["N/A"],"submitter_keywords":["COVID-19","SARS-CoV-2","2019 novel coronavirus infection","2019-nCoV infection","severe acute respiratory syndrome coronavirus 2","coronavirus disease 2019","SARS-coronavirus 2"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00001007837"],"sample_count":["739"],"description":["EGA dataset EGAD00001007837"],"repository":["EGA"],"title":["GEN_COVID_phenotype_lab"],"pubmed_abstract":["The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19<sup>1,2</sup>, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases<sup>3-7</sup>. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease."],"pubmed_title":["Mapping the human genetic architecture of COVID-19."],"pubmed_authors":[""],"name_synonyms":["WBSCR5, l(1)EA142., NK-2, lab, dhc64C, VND, Vnd, nk-2, Dhc46C, l(3)64Ca, NK2, Fs(3)Sz18, CG7507, l(1)GA100, Cdhc, dNK-2, l(1)VE769, l(1)1Bf, l(1)VA208, Fs(3)Laborc, Dm vnd, dhc64c, DmelCG7507, l(1)EC6, cDhc64C, vnd/NK-2, WBSCR15, Dhc64c, Dynein, DHC64C, DmelCG6172, Dhc, DHC, HDC16822, cDhc, Dhc64, NTAL, EG:118B3.1, EC6, FCP-A, HSPC046, dhc, l(1)GA122, CD, Phenotypes, WBS15, Su(Gl)77, Lab, LAB, CG6172, Dm-NK2, HMW MAP, Nkx2, l(1)RC24, Fs(3)Lab"],"description_synonyms":["WBSCR5, l(1)EA142., NK-2, lab, dhc64C, VND, Vnd, nk-2, Dhc46C, l(3)64Ca, NK2, Fs(3)Sz18, CG7507, l(1)GA100, Cdhc, dNK-2, l(1)VE769, l(1)1Bf, l(1)VA208, Fs(3)Laborc, Dm vnd, dhc64c, DmelCG7507, l(1)EC6, cDhc64C, vnd/NK-2, WBSCR15, Dhc64c, Dynein, DHC64C, DmelCG6172, Dhc, DHC, HDC16822, cDhc, Dhc64, NTAL, EG:118B3.1, EC6, FCP-A, HSPC046, dhc, l(1)GA122, CD, WBS15, Su(Gl)77, Lab, LAB, CG6172, Dm-NK2, HMW MAP, Nkx2, l(1)RC24, Fs(3)Lab"],"pubmed_title_synonyms":["COVID19, Disease, Coronavirus Disease 19, human being, β-CoV, beta-CoV, Modern, COVID-19, familial, 2019-nCoV Infections., SARS-CoV-2, Virus Infection, COVID-19 Virus Diseases, 2019 novel coronavirus, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, COVID 19 Virus Infection, Virus Disease, 2019 nCoV Disease, Human, COVID-19 Virus Disease, 2019-nCoV Infection, Homo sapiens, 2019-nCoV Disease, SARS CoV 2 Infection, Infection, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Coronavirus, COVID-19 Virus Infections, β-coronavirus, Man, 2019-nCoV, COVID 19 Pandemic, β-CoVs, betacoronavirus, Disease 2019, Man (Taxonomy), Pandemic, COVID-19 Virus Infection, Coronavirus Disease 2019, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, COVID-19 Pandemics, SARS-CoV-2 Infection, COVID-19 Pandemic, beta-CoVs, human, SARS-coronavirus 2, genetic, COVID-19 Virus, Modern Man, 2019 Novel Coronavirus Infection, inherited genetic, 2019-nCoV Diseases, constitutitional genetic, hereditary, COVID 19 Virus Disease, SARS Coronavirus 2 Infection, COVID 19"],"pubmed_abstract_synonyms":["Adult-Onset Diabetes Mellitus, type 2, Product, Across, FON1, Autoimmune Process, let it be made, Virus Infection, Type 2 Diabetes Mellitus, Progress Reports, Risk Factor Score, fiat, FLORAL ORGAN NUMBER 1, CONSIST, ad, Risk Factors, Biological, parenchyma of lung, Associations, Summary Report, analysis, Non-Insulin Dependent Diabetes Mellitus, Importance Rating Score 0, Analysis, Biological Product, Consortium, WMS, Correlates, Centers, Ad, SEV, Biologic Drugs, Genomes, Progress Report, Maker, Coronavirus Disease 2019, Bdr, beta-CoVs, Clarify, SNAP-25, Ketosis-Resistant Diabetes Mellitus, NIDDM, Social, Biological Medicine, Field Reports, Health Correlates, Network Interface, Role Concepts, Medicine, Birth Place, Homo sapiens disease, Infections and Infestations, Biologic Drug, COVID 19 Virus Disease, SGS, 2019-nCoV Infections, Communities, SARS-CoV-2 Viruses, Viral, β-CoV, pulmo, Biologic Products, Global, familial, SARS-CoV-2, lung parenchyma, Coronavirus 2, 2019 nCoV Infection, COVID 19 Virus Infection, ACMICD, Role Concept, Representation, Adult-Onset Diabetes, SARS-CoV-2 Virus, Neighborhood, Role, GENA70, Ketosis Resistant, RELATIONSHIP, Maturity-Onset Diabetes Mellitus, Smoking, statistical significance, tobacco use disorder, Social Risk Factors, whole organism, Pandemic, Biological Medicines, Biological Drug, Field, Type II Diabetes, Infection and Infestation, Biologics, whole genome, International, Report, non-insulin-dependent, pulmonary, Severity, Koerper, Arrangement, 2019, Residence Characteristic, Supportive, 2019-nCoV Diseases, Previous, Slow-Onset, hypertension, Community, FLORAL DEFECTIVE 10, T2DM - 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samples","description":"Lab values for GEN_COVID cohort.","dates":{"updated":"2021-08-09 12:39:48"},"accession":"EGAD00001007837","cross_references":{"TAXONOMY":["9606"],"pubmed":["34237774"],"OLS":["MONDO_0100096"],"EGA":["EGAC00001002188","EGAS00001005304"]}}