Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

EGAGenomicsN/Ahttps://ega-archive.org/datasets/EGAD000010103001EGA dataset EGAD00001010300EGAEnhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomicsfalse5796737e-4882-4a48-afe6-b2d7f2dd829b - samplesThe circulating tumor DNA (ctDNA) mutation-based approach shows limited performance in minimal residual disease (MRD) detection, especially for landmark MRD detection at an early-stage cancer after surgery. Here, A total of 87 NSCLC patients, who received curative surgical resections (23 patients relapsed during follow-up), enrolled in this study. A total of 163 plasma samples, collected at 7 days and 6 months postsurgical, were used for high-throughput sequencing.2023-05-05 13:04:10EGAD000010103009606EGAC00001003206EGAS00001007192