{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["Illumina HT 12"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00010000436"],"sample_count":["1302"],"description":["EGA dataset EGAD00010000436"],"repository":["EGA"],"title":["Title not provided"],"pubmed_abstract":["Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator. Although EMSY has been linked to transcriptional silencing, its mechanism of action is unknown. Here, we report that EMSY acts as an oncogene, causing the transformation of cells in vitro and potentiating tumor formation and metastatic features in vivo. We identify an inverse correlation between EMSY amplification and miR-31 expression, an antimetastatic microRNA, in the METABRIC cohort of human breast samples. Re-expression of miR-31 profoundly reduced cell migration, invasion, and colony-formation abilities of cells overexpressing EMSY or haboring EMSY amplification. We show that EMSY is recruited to the miR-31 promoter by the DNA binding factor ETS-1, and it represses miR-31 transcription by delivering the H3K4me3 demethylase JARID1b/PLU-1/KDM5B. Altogether, these results suggest a pathway underlying the role of EMSY in breast cancer and uncover potential diagnostic and therapeutic targets in sporadic breast cancer."],"pubmed_title":["The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31."],"pubmed_authors":["Viré Emmanuelle E, Curtis Christina C, Davalos Veronica V, Git Anna A, Robson Samuel S, Villanueva Alberto A, Vidal August A, Barbieri Isaia I, Aparicio Samuel S, Esteller Manel M, Caldas Carlos C, Kouzarides Tony T"],"name_synonyms":["Raw., Svc, Bru, Del(8)44H, Col4a-1"],"pubmed_title_synonyms":["HH, primary breast cancer, malignant tumor of the breast, Neoplasms, stRNA, hg., Emsy, bar, mammary neoplasm, Mammary Cancers, Gene, Human Mammary Neoplasms, Tumor, IDOL, Human, AU019557, Hh, Small, Breast Malignant Tumor, anon-WO0134654.19, DmelCG4637, \"neoplasm of breast (disorder)\" EXACT [SNOMEDCT_2005_07_31:126926005], Breast Tumor, EMSY, \"mammary tumor\" EXACT [CSP2005:2016-0671], breast tumor, cancer of the breast, Transforming, Mir, MIR, Miranda, BC, Mammary Neoplasms, malignant neoplasm of breast, AU019521, DmelCG15356, Human Mammary, Small Temporal, Transforming Gene, MONDOA, Mammary Neoplasm, Mrt, Mammary Carcinoma, Human Mammary Carcinomas, mir, miRNA, Primary miRNA, INSDC_feature:ncRNA, pri-miRNA, Cancer of the Breast, Transforming Genes, Myosin regulatory light chain-interacting protein, cancer of breast, Malignant Tumor of Breast, bar-3, Mammary, Mammary Cancer, bHLHe36, Breast, mammary cancer, transcription from bacterial-type RNA polymerase promoter, mammary tumor, Idol, Breast Malignant Neoplasms, pre miRNA, Tumors, Cancer, 9430057C20Rik, 2310016L09Rik, Breast Carcinoma, Human Mammary Neoplasm, Carcinoma, RNA, l(3)hh, Breast Carcinomas, \"breast neoplasm\" EXACT [MTH:120], Myosin regulatory light chain interacting protein, 6.3.2.-, Small Temporal RNA, Primary, \"breast tumor\" EXACT [NCI2004_11_17:C2910], CG4637, Breast Malignant Neoplasm, CG12249, AW228700, Micro RNA, Mammary Carcinomas, bar3, Neoplasm, Human Mammary Carcinoma, NOS, DmelCG12249, pre-miRNA, Malignant Neoplasm of Breast, Carcinomas, pri miRNA, miRNAs, Breast Neoplasm, Genes, l(3)neo56, l(3)neo57, Micro, Temporal RNA, Mira, Primary MicroRNA, Inducible degrader of the LDL-receptor, Cancers, \"mammary neoplasm\" RELATED [], Oncogene, breast cancer, anon-WO0182946.19, bacterial transcription, Breast Tumors, Breast Cancer, MIRA, Breast Malignant Tumors, Cancer of Breast, MicroRNA, cancer, breast"],"description_synonyms":["Illumina Sequencing Technology, Illumina., Illumina Sequencing"],"pubmed_abstract_synonyms":["mode of action, malignant tumor of the breast, Breasts, pharmacodynamics, Materials, Elk1, Feature, ELK3, mKIAA4034, bar, Lactiferous gland, mammary neoplasm, Human Mammary Neoplasms, Progress Reports, Tumor, IDOL, glandula mammaria, RBBP2H1A, AU019557, Small, Techniques, anon-WO0134654.19, AI196000, DmelCG4637, Ets-1, Roles, \"neoplasm of breast (disorder)\" EXACT [SNOMEDCT_2005_07_31:126926005], Summary Report, AA959943, Concepts, EWSR2, cancer of the breast, Transforming, Mir, MIR, Cell Motility, Summary Reports, multicellular organismal biosynthetic process, Miranda, BC, Mammary Neoplasms, malignant neoplasm of breast, AU019521, DmelCG15356, single-organism biosynthetic process, Small Temporal, D1Ertd202e, Man (Taxonomy), Progress Report, hypoplasia, Human Mammary Carcinomas, Cell Locomotion, mir, miRNA, Primary miRNA, RBP2-H1, INSDC_feature:ncRNA, pri-miRNA, Acts, Progress, Jumonji|ARID domain-containing protein 1B, Movements, Transforming Genes, Field Reports, D230050P06, cancer of breast, Role Concepts, Therapies, Locomotion, Malignancies, Ovarian Cancers, Reagents, mammary cancer, transcription from bacterial-type RNA polymerase promoter, Idol, Breast Malignant Neoplasms, Tumors, mamma, Acta-2, 9430057C20Rik, 2310016L09Rik, Therapy, Motility, Carcinoma, Cancer of Ovary, \"breast neoplasm\" EXACT [MTH:120], Etsoncb, 6.3.2.-, Modern, Cell Migration, CT31, Aptitudes, Small Temporal RNA, Actsk-1, Test, CG4637, Ability, CG12249, Benign, Role Concept, Investigative Report, Lobe of mammary gland, bar3, Role, Genetic Materials, NOS, pre-miRNA, Malignant Neoplasm of Breast, Genetic Material, Ovary Neoplasm, pri miRNA, Carcinomas, miRNAs, Tpl1, l(3)neo56, In Vitro, l(3)neo57, Micro, AW556288, Tests, Mira, Field, Benign Neoplasms, INSDC_feature:gene, Ovary Neoplasms, Inducible degrader of the LDL-receptor, \"mammary neoplasm\" RELATED [], Features, Treatments, human, Malignant Neoplasms, metastatic, Report, Oncogene, breast cancer, Material, bacterial transcription, Breast Tumors, Indicator, MIRA, Breast Malignant Tumors, Cistron, MicroRNA, 1.14.11.-, other neoplasm, cancer, hg, HH, Ovary Cancer, mammary region, primary breast cancer, Migration, human being, PUT1, In Vitro as Topic, Testings, Reagent, Neoplasms, stRNA, p54, Emsy, Benign Neoplasm, Histone demethylase JARID1B, Gene, Mammary Cancers, JARID1B, Malignant, Hh, Human, In Vitro Testing, Retinoblastoma-binding protein 2 homolog 1, Breast Malignant Tumor, Investigative, Homo sapiens, reduced, Ovarian, Demethylase, Breast Tumor, EMSY, \"mammary tumor\" EXACT [CSP2005:2016-0671], breast tumor, tiny, Cancer|testis antigen 31, Reagents and Indicators, Technique, Man, In Vitro Tests, XE1-b, In, Human Mammary, Genetic, Transforming Gene, MONDOA, Malignancy, Mammary Neoplasm, Mrt, Mammary Carcinoma, Ovarian Cancer, plasmid binding, mammary part of chest, Indicators, PLU1, Cell Movements, Plu1, Cancer of the Breast, Neoplasias, Movement, Abilities, microtubule/chromatin interaction, Myosin regulatory light chain-interacting protein, mechanism of action, bar-3, Malignant Tumor of Breast, Mammary, Mammary Cancer, ets1-B, Characteristics, bHLHe36, Investigative Reports, Breast, mammary tumor, pre miRNA, Cancer, small, Breast Carcinoma, Human Mammary Neoplasm, l(3)hh, RNA, PPP1R98, structure-specific DNA binding, Breast Carcinomas, Malignant Neoplasm, Myosin regulatory light chain interacting protein, ets-1, Ovary, Primary, \"breast tumor\" EXACT [NCI2004_11_17:C2910], Cistrons, Brustdruese, Ovary Cancers, Cell, Testing, Concept, Breast Malignant Neoplasm, AW228700, In Vitro Test, H3K4me3, Characteristic, Micro RNA, Mammary Carcinomas, Jarid1b, Research Reports, Neoplasm, In Vitro Testings, structure specific DNA binding, Human Mammary Carcinoma, DmelCG12249, PLU-1, 2010009J12Rik, Vitro Testing, INSDC_feature:regulatory, Cancer of the Ovary, Breast Neoplasm, Genes, DMTase, 2210016I17Rik, underdeveloped, AI448617, Temporal RNA, Lobe of breast, Talents, Primary MicroRNA, Cancers, Breast Malignant Neoplasms., ETS-1, Rb-Bp2, Methyl-CpG-binding protein MBD2, Ovarian Neoplasm, pharmacologic action, Reports, anon-WO0182946.19, Therapeutic, Talent, Modern Man, Breast Cancer, In Vitro Technique, Cancer of Breast, Treatment, Summary, Neoplasia, breast, Field Report"],"additional_accession":[]},"is_claimable":false,"name":"Illumina_HT12_raw - samples","description":"Illumina HT 12 IDAT files","dates":{"updated":"2019-02-01 15:51:47"},"accession":"EGAD00010000436","cross_references":{"TAXONOMY":["9606"],"pubmed":["24582497"],"EGA":["EGAC00001000484","EGAS00000000122"]}}