{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["N/A"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00010000738"],"sample_count":["18336"],"description":["EGA dataset EGAD00010000738"],"repository":["EGA"],"title":["Title not provided"],"pubmed_abstract":["The association between APOE genotype and cognitive function suggests a positive role for the e2 allele and a negative role for the e4 allele. Both alleles have relatively low frequencies in the general population; hence, meta-analyses have been based on many small, heterogeneous studies. Here, we report the APOE-cognition associations in the largest single analysis to date. APOE status and cognitive ability were measured in 18 337 participants from the Generation Scotland study between 2006 and 2011. The age range was 18-94 years with a mean of 47 (SD 15). Four cognitive domains were assessed: verbal declarative memory (paragraph recall), processing speed (digit symbol substitution), verbal fluency (phonemic verbal fluency), and vocabulary (Mill Hill synonyms). Linear regression was used to assess the associations between APOE genetic status and cognition. Possession of the e4 allele was associated with lower scores on the measures of memory and processing speed in subjects aged >60. Across all age ranges, the e4 allele was linked to better verbal fluency scores. In younger subjects (≤60 years) the e4 allele was linked to higher vocabulary scores. There were no associations between the e2 allele and cognitive ability. As seen in previous meta-analyses, the APOE e4 allele is linked to poorer cognitive performance in the domains of memory and processing speed. By contrast, positive associations were seen between the e4 allele and measures of verbal fluency and vocabulary. All associations were relatively small and, in many cases, nominally significant despite the very large sample size."],"pubmed_title":["Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course."],"pubmed_authors":["Marioni Riccardo E RE, Campbell Archie A, Scotland Generation G, Hayward Caroline C, Porteous David J DJ, Deary Ian J IJ"],"description_synonyms":["APO-E, LDLCQ5, Apo E Isoproteins, LPG, APOEA, Apo E, AD2, Apoprotein (E), Apo-E, Isoproteins, apo-E, Apolipoprotein E Isoproteins, Apolipoprotein E, ApoE, APOE, AI255918., Apoproteins E"],"pubmed_abstract_synonyms":["APO-E, Apo E Isoproteins, Mental, big, Cognitive Function, limb digit, Allelomorphs, digit ( phalanges plus metapodial) plus soft tissue, Size, determination, Cognitive Processing Speeds, Psychomotor Speeds, acropodial unit, Mbp1, Psychomotor Speed, Progress Reports, Mental Processing, froggy, Gyltl1a, School-Age, Memory for Designs Test, NEUROPSYCHOL TESTS, large, APOEA, Investigative, reduced, Roles, Associations, Summary Report, Genetic heterogeneity, Neuropsychological Tests, Concepts, Neuropsychologic Test, Sample Sizes, Low, tiny, Aphasia, myd, Summary Reports, Processing Speed, Neuropsychologic Tests, processing speed, LPG, School-Age Populations, study, me75, Cognitive Processing Speed, Progress Report, Vocabularies, MDDGB6, Isoproteins, hypoplasia, Psychomotor Processing Speeds, apo-E, Mbp-1, LARGE, general cognitive function, Population, ApoE, APOE, D17Mit170, cognitive performance, T1, Genotypes, Cognitive Functions, Allelomorph, genetic, Progress, Neuropsychological, BPFD#36, Cognitions, Field Reports, TEST NEUROPSYCHOL, Functions, great, Role Concepts, AD2, Apo-E, Allele, Apolipoprotein E Isoproteins, School Age Population, Investigative Reports, constitutitional genetic, Apoproteins E, small, digit (phalangeal portion) plus soft tissue, general cognitive ability, cou, gyltl1b-b, RnBP, familial, GlcNAc 2-epimerase, Test, Insight, Tl3, Tl2, cognitive ability, Aphasia Test, Aphasia Tests, AI255918, digit, cognitive function, Concept, LDLCQ5, Insights, N-acetyl-D-glucosamine 2-epimerase, Lr, Role Concept, Genogroup, Investigative Report, Processing Speeds, School Age, MDDGA6, RENBP, mKIAA0609, Research Reports, chemical analysis, Role, Sizes, TESTS NEUROPSYCHOL, digit skeleton, KIAA0609, Psychomotor Processing Speed, fg, Populations, cognitive test performance, gyltl1b, Mental Processing Speed, Psychomotor, NEUROPSYCHOL TEST, underdeveloped, Mental Processing Speeds, Tests, Apoprotein (E), Processing, Function, Heterogeneity, Field, mdc1d, expanded, Apolipoprotein E, Cognitive, cognitive performance test, School Age Populations, AGE, Speed, Genogroups, MDC1D, Report, Sample, enr, Reports, Cognitive Processing, enlarged, Apo E, Bra, renin-binding protein, inherited genetic, School-Age Population, assay, Summary, forelimb digit, hereditary, Psychomotor Processing, Sample., Field Report, Elderly, Neuropsychologic"],"name_synonyms":["APO-E, LDLCQ5, Apo E Isoproteins, LPG, APOEA, Apo E, AD2, Apoprotein (E), Apo-E, Isoproteins, apo-E, Apolipoprotein E Isoproteins, Apolipoprotein E, ApoE, APOE, AI255918., Apoproteins E"],"pubmed_title_synonyms":["APO-E, LDLCQ5, Apo E Isoproteins, LPG, APOEA, lifespan, general cognitive ability, entire lifespan, Apo E, entire life cycle, AD2, Apoprotein (E), Apo-E, life., Isoproteins, apo-E, Apolipoprotein E Isoproteins, Apolipoprotein E, general cognitive function, ApoE, APOE, cognitive ability, Apoproteins E, AI255918"],"additional_accession":[]},"is_claimable":false,"name":"GS_APOE - samples","description":"Generation Scotland APOE data","dates":{"updated":"2017-07-26 15:39:25"},"accession":"EGAD00010000738","cross_references":{"TAXONOMY":["9606"],"pubmed":["26395552"],"EGA":["EGAC00001000332","EGAS00001001235"]}}