EGAGenomicsN/Ahttps://ega-archive.org/datasets/EGAD000100007876487EGA dataset EGAD00010000787EGA<h4>Background</h4>The prevalence of asthma and allergic diseases has increased in industrialised countries, and it is known that rates vary according whether the area is urban or rural and to socio-economic status. Surveys conducted in some urban settings in Latin America found high prevalence rates, only exceeded by the rates observed in industrialised English-speaking countries. It is likely that the marked changes in the environment, life style and living conditions in Latin America are responsible for these observations. The understanding of the epidemiological and immunological changes that underlie the increase in asthma and allergic diseases in Latin America aimed by SCAALA studies in Brazil and Ecuador will be crucial for the identification of novel preventive interventions.<h4>Methods/design</h4>The Salvador-SCAALA project described here is a longitudinal study involving children aged 4-11 years living in the city of Salvador, Northeastern Brazil. Data on asthma and allergic diseases (rhinitis and eczema) and potential risk factors will be collected in successive surveys using standardised questionnaire. This will be completed with data on dust collection (to dust mite and endotoxin), skin test to most common allergens, stool examinations to helminth and parasites, blood samples (to infection, total and specific IgE, and immunological makers), formaldehyde, physical inspection to diagnoses of eczema, and anthropometric measures. Data on earlier exposures when these children were 0-3 years old are available from a different project.<h4>Discussion</h4>It is expected that knowledge generated may help identify public health interventions that may enable countries in LA to enjoy the benefits of a "modern" lifestyle while avoiding--or minimising--increases in morbidity caused by asthma and allergies.While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture. We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based genome-wide analysis of 6,487 individuals was performed in the context of worldwide genomic diversity to elucidate how ancestry, kinship, and inbreeding interact in three populations with different histories from the Northeast (African ancestry: 50%), Southeast, and South (both with European ancestry >70%) of Brazil. We showed that ancestry-positive assortative mating permeated Brazilian history. We traced European ancestry in the Southeast/South to a wider European/Middle Eastern region with respect to the Northeast, where ancestry seems restricted to Iberia. By developing an approximate Bayesian computation framework, we infer more recent European immigration to the Southeast/South than to the Northeast. Also, the observed low Native-American ancestry (6-8%) was mostly introduced in different regions of Brazil soon after the European Conquest. We broadened our understanding of the African diaspora, the major destination of which was Brazil, by revealing that Brazilians display two within-Africa ancestry components: one associated with non-Bantu/western Africans (more evident in the Northeast and African Americans) and one associated with Bantu/eastern Africans (more present in the Southeast/South). Furthermore, the whole-genome analysis of 30 individuals (42-fold deep coverage) shows that continental admixture rather than local post-Columbian history is the main and complex determinant of the individual amount of deleterious genotypes.Cohort profile: the Bambui (Brazil) Cohort Study of Ageing.Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study).Cohort profile: the 1982 Pelotas (Brazil) birth cohort study.Lima-Costa Maria Fernanda MF, Firmo Josélia O A JO, Uchoa Elizabeth EKehdy Fernanda S G FS, Gouveia Mateus H MH, Machado Moara M, Magalhães Wagner C S WC, Horimoto Andrea R AR, Horta Bernardo L BL, Moreira Rennan G RG, Leal Thiago P TP, Scliar Marilia O MO, Soares-Souza Giordano B GB, Rodrigues-Soares Fernanda F, Araújo Gilderlanio S GS, Zamudio Roxana R, Sant Anna Hanaisa P HP, Santos Hadassa C HC, Duarte Nubia E NE, Fiaccone Rosemeire L RL, Figueiredo Camila A CA, Silva Thiago M TM, Costa Gustavo N O GN, Beleza Sandra S, Berg Douglas E DE, Cabrera Lilia L, Debortoli Guilherme G, Duarte Denise D, Ghirotto Silvia S, Gilman Robert H RH, Gonçalves Vanessa F VF, Marrero Andrea R AR, Muniz Yara C YC, Weissensteiner Hansi H, Yeager Meredith M, Rodrigues Laura C LC, Barreto Mauricio L ML, Lima-Costa M Fernanda MF, Pereira Alexandre C AC, Rodrigues Maíra R MR, Tarazona-Santos Eduardo EVictora Cesar G CG, Barros Fernando C FCBarreto Mauricio L ML, Cunha Sergio S SS, Alcântara-Neves Neuza N, Carvalho Lain P LP, Cruz Alvaro A AA, Stein Renato T RT, Genser Bernd B, Cooper Philip J PJ, Rodrigues Laura C LCepigen, 2310069M11Rik, Epithelial., Mitogen, epg, Epithelial Mitogenepigen, 2310069M11Rik, Epithelial., Mitogen, epg, Epithelial Mitogenstudy, ageing.year, Formol, exercise induced asthma, Bogalusa Heart Study, Reactive airway disease, Skin Test, Atopic, Design, Physical, YEAR, Risk Factor Score, Survey Methods, Heart Study, Asthmas, Questionnaire Designs, INSPECTION, Risk Factors, Method, California, Lifestyle Factor, Survey Methodology, Methanal, Likely, California Teachers Study, Generation, Randomized Response, Correlates, Eczematous Dermatitis, Project ENABLE, E, Physical Restraint, Allergic, Rural Area, COMPLETED, Oxomethane, procedures, Community Health, Social, a, Health Correlates, Familiar, allergic dermatitis, Homo sapiens disease, Syphilis Study, Year, Infections and Infestations, INCREASED, Nematomorpha, Jackson, Difference, Epidemiology, Exceeding, assessment, Anticipated, Longitudinal Survey, Test, Jackson Heart, Procedure, Questionnaire Design, Collected, Life Styles, Housedust, Atopic dermatitis and related conditions (disorder), SEND-DESIGN, Educate, Urbanized Area, Marked, Discussion, ENG, Physical Assessment, Social Risk Factors, Nonrespondent, Urban, Infection and Infestation, Eczema, Methodological, surveillance, Present, Children, Condition, Infantile Eczema, Atopic Dermatitis, living, atopic eczema, Surveys, Preventive Medicine & Public Health, Preventive Medicine and Public Health, Tuskegee Syphilis Studies, Elderly, Community, Mite, Potential, Dermatitis, years, Different, Period Prevalences, Discuss, Available, Aid, inspection, Collected Value, physical_exam, Immunologically Directed Therapy, Community Survey, Bogalusa, Baseline Surveys, disease or disorder, Randomized, Atopic Dermatitides, Randomized Response Techniques, Allergic Reactions, Bronchial Asthma, Exceeded, ordure, PHYSICAL EXAMINATION, Disseminated Neurodermatitides, Technique, Assisted, Longitudinal Surveys, Risk Factor, Lifestyle Factors, Jackson Heart Studies, In, Complete, Aschelminthes, Framingham Heart Studies, occurrence, prevalence, Nasal, ATOD, exercise-induced asthma, Respondent, Questionnaires and Surveys, Acarus, clinical infection, Population at Risk, Jackson Heart Study, Study, Formalin, atopic, Completion, generalized epilepsy, Drl, Atopic Neurodermatitides, New, Probably, Life Style Induced Illness, Benefit, whole blood, atopic dermatitis and related conditions, Longitudinal Study, Conditions, Teachers Studies, disorders, INTERVENTIONS, eczematous dermatitis, California Teachers Studies, Factor, Tuskegee, eczema, ASTHMA, spoor, OTHER ATOPIC DERMATITIS, Collecting, Mdu, Availability, Neurodermatitis, Heart Studies, City, mda, Public, condition, IMMUNOTHERAPY, background, Collection, Lifestyles, Skin, outbreaks, ami, excrement, hypersensitivity, salvador, increased number, Response Technique, med, Increased, Likeliness, atopic neurodermatitis, Understanding, Framingham, Neurodermatitides, Disseminated, Generated, Differential, Parasitic Worms, Framingham Heart Study, Oxomethylene, Point, Specific, protozoa, Disseminated Neurodermatitis, English, epidemics, Completed, Atopic Neurodermatitis, physical exam, droppings, Allergen, runny nose, atopic dermatitis, Period Prevalence, Physical Exam, Helminth, Infestations and Infections, House Dust, Nurture, CG11121, Preventive, Bogalusa Heart, Immunoglobulins, Readability, Techniques, Point Prevalence, old, diseases, Completely, Point Prevalences, RA, Project, Impacts, diseases and disorders, Nonrespondents, Environmental Impacts, Bogalusa Heart Studies, Parasitic, DESIGN, increased, human disease, Observed, pre-mortem, Identification, Prevalences, Formaldehyd, Designs, Questionnaires, Lifestyle, study completion, General Examination, SO, Rural, Environmental Impact, Eczematous, Novel, chronic obstructive asthma, CDISC Interventions Class, Methodological Studies, Respondents, Visual Inspection, Besnier's prurigo, Nasal Catarrhs, Reaction, So, PHYSICAL EXAM, Prevalence, Questionnaire, Aschelminthe, Catarrh, Benefits, UA, Epidemiologic, frequency, allergic form of dermatitis, helminthology, High Prevalence, Infantile, Teachers Study, Expected, Longitudinal, Years, Observational, Inspection, Hypersensitivities., Diseases, YEARS, Custodian, Score, Conflict, Observation, Study Design, Nasal Catarrh, Parasitic Worm, Epistemology, IgE, Factors, Risk, Tests, chronic obstructive asthma with acute exacerbation, epidemiology, Nematomorphas, common, Presence, Survey Method, Methodological Study, morbidity, Northeastern, Identified, disease, Social Risk, Dermatitides, Health, Parasite, Dust, Gordius, Physical Examination, parasites, Person Responsible, accessory, CDISC SEND Study Design Terminology, other disease, Other atopic dermatitis and related conditions, Procedures, Material Identification, Worm, Feces, supernumerary, House, DmelCG11121, Baseline, preventive, Asthma, Studies, Survey, Rhinitides, Help, Methodology, somda, Populations at Risk, PRESENT, Galapagos Islands, Exceed, Risk Score, Responsible, Worms, non-neoplastic, Heightened, Infestation and Infection, PHYSICAL, COLLECTING, Found, Social Risk Factor, disorder, Randomized Response Technique, Known, Study Completed, chronic obstructive asthma with status asthmaticus, Epidemiological, incidence, Morbidities, Repeated Rounds of Survey, Allergy, California Teachers, physical examination, English Language, Endotoxin, OBSERVATION, Immunotherapy, medical condition, Risk Factor Scores, Assistance, Catarrhs, Impact, Environmental, Syphilis Studies, Period, hypersensitivity reaction type I disease, ENABLE, Allergies, Infection, Physical or Textual Reference to Actual Test or Parameter, FORMALIN, techniques, Environment, Immunological Therapy, Methods, Northeast, Community Surveys, Response Techniques, Allergic Reaction, Responsible Person, Assessment, Reactions, Completed Study, Tuskegee Syphilis Study, COMPLETE, dermatitis, immunotherapy, protozoology, endemics, Methylene oxide, introduction, Immunological, Annum, Risk Scores, Specified, present in greater numbers in organism, Baseline Survey, Increase, Study Completed Status, Environments, Interventions, Bronchial, Total, Clinical Trial Inspection, Assist, Advise Before Life Ends, methodologyfalseEpigen-Brasil - samplesEpigen-Brasil samples using HumanOmni2.52017-07-26 15:39:26EGAD00010000787960626124090167967291637337520805109EGAC00001000330EGAS00001001245