{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"dataset_type":["Codelink Human Whole Genome Bioarray"],"full_dataset_link":["https://ega-archive.org/datasets/EGAD00010001425"],"sample_count":["9"],"description":["EGA dataset EGAD00010001425"],"repository":["EGA"],"title":["Codelink_HWG_noCLD_CB"],"pubmed_abstract":["Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O<sub>2</sub>). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O<sub>2</sub> In the context of MV-O<sub>2</sub>, attenuated PDGF signaling independently contributes to defective septation and endothelial cell apoptosis stemming from a PDGF-Rα-dependent reduction in lung VEGF-A. TGF-β contributes to the PDGF-Rα-dependent decrease in myofibroblast function. Remarkably, endotracheal treatment with exogenous PDGF-A rescues both the lung defects in haploinsufficient mice undergoing MV-O<sub>2</sub> Overall, our results establish attenuated PDGF signaling as an important driver of nCLD pathology with provision of PDGF-A as a protective strategy for newborns undergoing MV-O<sub>2</sub>."],"pubmed_title":["Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease."],"pubmed_authors":["Oak Prajakta P, Pritzke Tina T, Thiel Isabella I, Koschlig Markus M, Mous Daphne S DS, Windhorst Anita A, Jain Noopur N, Eickelberg Oliver O, Foerster Kai K, Schulze Andreas A, Goepel Wolfgang W, Reicherzer Tobias T, Ehrhardt Harald H, Rottier Robbert J RJ, Ahnert Peter P, Gortner Ludwig L, Desai Tushar J TJ, Hilgendorff Anne A"],"additional_accession":[]},"is_claimable":false,"name":"Codelink_HWG_noCLD_CB","description":"Codelink Human Whole Genome from Blood taken at 72 hours after birht","dates":{"updated":"2017-11-26 20:50:51"},"accession":"EGAD00010001425","cross_references":{"TAXONOMY":["9606"],"pubmed":["28923828"],"EGA":["EGAC00001000698","EGAS00001002586"]}}