EGA00310Genomicsunknown, Affymetrix 500KGWAShttps://ega-archive.org/studies/EGAS00000000011EGAEGA study EGAS00000000011Title not providedWTCCC1 1958BC control datasetrestrictedEGAThere is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5 x 10(-7): 1 in bipolar disorder, 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. On the basis of prior findings and replication studies thus-far completed, almost all of these signals reflect genuine susceptibility effects. We observed association at many previously identified loci, and found compelling evidence that some loci confer risk for more than one of the diseases studied. Across all diseases, we identified a large number of further signals (including 58 loci with single-point P values between 10(-5) and 5 x 10(-7)) likely to yield additional susceptibility loci. The importance of appropriately large samples was confirmed by the modest effect sizes observed at most loci identified. This study thus represents a thorough validation of the GWA approach. It has also demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; has generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in the British population is generally modest. Our findings offer new avenues for exploring the pathophysiology of these important disorders. We anticipate that our data, results and software, which will be widely available to other investigators, will provide a powerful resource for human genetics research.Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Rheumatoid, portion of blood, study, Controlling, wide/broad, reference sample, rheumatic, Chronic rheumatic arthritis, whole blood, Genomes, Arthritis, vertebrate blood., Birth, Rheumatoid arthritis NOS (disorder), rheumatoid, susceptibility to, Parturitions, broad, Rheumatoid arthritis NOS, Rheumatic gout, RA - Rheumatoid arthritis, Rheumatoid disease, RhA - Rheumatoid arthritis, wide, Rheumatoid Arthritis, atrophic arthritis, Births, Associations, autoimmune arthritis, Rheumatoid arthritis (disorder), rheumatoid arthritis, RA, progression of, arthritis, Arthritis or polyarthritis, Childbirths, atrophic Arthritis, arthritis or polyarthritis, Proliferative arthritis, Controlled, ChildbirthGenome-Wide Association, GWA Study, other disease, human disease, Genome Wide Association Analysis, Whole Genome Association Study, GWA, disorders, common, Genome-Wide, Genome Wide Association Studies, Genome Wide Association Scan, Genome-Wide Association Studies, non-neoplastic, Study, disease, GWA Studies, diseases, Genome Wide Association Study, Diseases, Studies, Association Studies, disease or disorder, condition, disorder, Homo sapiens disease, diseases and disorders, medical condition., Association Study, Whole Genome Association Analysisextent, type 2, Materials, noninsulin-dependent diabetes mellitus, Laboratory, PNT-P1, EY3-1, Rheumatoid arthritis NOS, 5730420M11Rik, coronary artery disorder, Rheumatoid disease, Relative, RhA - Rheumatoid arthritis, Associations, Joint, Heart Disease, Gastritis Associated with Crohn Disease, symptoms, Non-Insulin Dependent Diabetes Mellitus, 2, Software Engineering, D-ets-2, 3520, Research Activity, with unspecified complication, myd, Laboratory Research, CORONARY ARTERY DIS, Priorities, SET, Genomes, Arthritis, rheumatoid, phosphatase 2A inhibitor I2PP2A, Mbp-1, number of, NIDDM, DmelCG4299, set, Homo sapiens disease, Bipolar Mood, Bipolar Disorder, severe, Type 1 Diabetes Mellitus, CHD, Left Main Coronary Disease, screening, Coronary Heart Diseases, Crohn's disease of colon, Regional, completeness, Research Priorities, depressive-manic psych., Manic Depressive Psychosis, Software Tools, Coronary Artery, Computer Applications, mKIAA0609, Insulin-dependent diabetes, Relative Risks, Computer Applications Software, type I diabetes mellitus, Research and Development, fg, pntP2, Software Applications, HLA-DR-associated protein II, Pointed-P1, Crohn Disease, DI-2, Source Software, I-2Dm, Ets94F, Type II Diabetes, expanded, Diabetes mellitus type I [insulin dependent type] [IDDM] [juvenile type], signs, Atherosclerosis, inhibitor of granzyme A-activated DNase, human, I-2PP1, Bipolar Affective, CHD (coronary heart disease), Activities, Phenotypes, MDC1D, Applications, TAF-IBETA, non-insulin-dependent, enr, Material, Rheumatoid arthritis (disorder), TAF-Ibeta, School-Age Population, Affective Psychosis, hypertension, Computer Software Applications, coronary artery disease, big, 0998/12, Juvenile diabetes, maturity-onset diabetes, Psychosis, Gastritis Associated with Crohn's Disease, number, Rheumatic gout, major bipolar affective disorder, noninsulin dependent diabetes, Human, Manic Disorders, Ileocolitis, large, DMPOINT1A, Caucasian, bipolar depression, disease or disorder, Arterioscleroses, Crohns Disease, noninsulin-dependent, arthritis or polyarthritis, Application, School-Age Populations, Open Source Softwares, Chronic rheumatic arthritis, pointed-RC, Coronary Atheroscleroses, disorder of coronary artery, MDDGB6, Software Application, Rheumatoid arthritis NOS (disorder), dysfunction, Atheroscleroses, Coronary Artery Diseases, regional enteritis, Open Source Software, 2pp2a, manic bipolar affective disorder, Population, man, Research Activities., CG10574, EK3-2, Genotypes, Computer Software Application, Bipolar Affective Psychosis, l(3)07825, 2PP2A, Tools, dSET, dSet, Type 1 Diabetes, MAFD, progression of, CG17077, Development and Research, Manic-Depressive Illness, coronary heart disease, Ets, findings, grupo, Left Main Disease, disorders, CORONARY DIS, Genetics, Tool, Ileitis, pediatric Crohn's disease, I-2PP2A, autoimmune arthritis, Dm I-2, Crohn disease, condition, granulomatous colitis, Arteriosclerosis, pnt-P1, pnt-P2, bipolar affective disorder, Relative Risk, susceptibility, articulation, Coronary Atherosclerosis, School Age Populations, diabetes mellitis type 2, Computer Programs, Genogroups, Applications Softwares, Crohn's disease, protection against, digenic, POINT, CG8705, Diabetes Type 1, IPP2A2, joints, Bipolar Mood Disorders, CROHNS DIS, adult onset diabetes, Activity, DmelCG17077, Coronary Diseases, manic-depression, Mbp1, Bipolar Disorders, Pnt, Coronary, Enteritis, Insulin Dependent Diabetes, manic depressive disorder, manic depression, School-Age, Insulin dependent diabetes mellitus, png, diseases, major affective disorder, Bipolar Disorder Type 2, Bipolar Disorder Type 1, Mood Disorder, RA, Juvenile onset diabetes mellitus, diseases and disorders, not stated as uncontrolled, Arthritis or polyarthritis, Computer Program, Left Main Coronary Artery Disease, Pnt-P1, type II diabetes mellitus, human disease, Coronary Arteriosclerosis, reference sample, rheumatic, non-insulin dependent diabetes, TAF-I, Open, coronary disease, bipolar disorder, Computer Programs and Programming, non-insulin dependent diabetes mellitus, type 2 diabetes mellitus, CROHN DIS, RA - Rheumatoid arthritis, Granulomatous, IGAAD, paediatric Crohn's disease, type 2 diabetes mellitus non-insulin dependent, atrophic arthritis, DmelCG10574, Manic-depressive illness, type 2 diabetes, Research Priority, disease or disorder of coronary artery, CHD - Coronary heart disease, Rheumatoid, phapii, manic-depressive illness, joint, diabetes mellitis type II, wide/broad, gyltl1b-b, Manic-Depressive, StF-IT-1, T2DM - type 2 diabetes mellitus, Psychoses, Manic Depression, uncontrolled, D-Ets-2, white, ets94F, extra or missing physical or functional parts, 0123/09, late onset, results, Source Softwares, Programs, Program, School Age, MDDGA6, Diseases, Computer Applications Softwares, Genetic Materials, Coronary Arterioscleroses, Softwares, disease of coronary artery, Genetic Material, Populations, IDDM, gyltl1b, Risk, IDDM - Insulin-dependent diabetes mellitus, susceptibility to, manic bipolar I disorder, mdc1d, common, CG4299, Juvenile Diabetes, insulin resistance, insulin resistance-related, ptd, disease, type II, PntP2, wide, Artery Disease, Depression, enlarged, PntP1, type II diabetes, E(E2F)3D, microarray, Crohn's Disease, Cistron, PNTP2, i2pp2a, PNTP1, DMI UNSPF NT ST UNCNTRLD, Gruppe, other disease, human being, Type I Diabetes, ETS2, Ets2, Gene, Heart Diseases, Diabetes mellitus type 1 (disorder), broad, Computer, PHAPII, froggy, Gyltl1a, Depressions, pntegfr, 0608/07, template-activating factor I, rheumatoid arthritis, manic disorder, Type 1 Bipolar Disorder, non-insulin-dependent diabetes mellitus, Colitis, atrophic Arthritis, Coronary Heart, study, Genetic, Research, ipp2a2, Type I diabetes, Manic Disorder, Coronary Disease, non-neoplastic, adult-onset diabetes, BPFD#36, taf-ibeta, grupos, Disorder, great, has or lacks parts of type, articular joint, disorder, School Age Population, association with, Type 2 Bipolar Disorder, l(3)j1B7, diabetes, Controlled, Applications Software, Open Source, Controlling, Disease, data, coronary arteriosclerosis, Computer Software, CORONARY HEART DIS, igaad, medical condition, Regional Enteritis, Cistrons, Bipolar Depression, DMI UNSPF UNCNTRLD, group, mereological quality, Software Tool, Priority, CAD, Genogroup, I2PP2A, arthritis, Left Main Diseases, bipolar disorder manic phase, Software, Crohn's associated gastritis, l(3)s118306, Proliferative arthritis, Data Base, Manic, Type 2 Diabetes, diabetes mellitus, Artery Diseases, Manic-Depressive Psychosis, Risks, Bipolar, Engineering, Rest, coronary artery disease or disorder, pathophysiology, mixed bipolar disorder, dSET/TAF-Ibeta, Manic Depressive, Rheumatoid Arthritis, 2610030F17Rik, Ets58AB, Coronary Artery Disease, Terminal, cardinality, manic-depressive psychosis, Crohn's disease of large bowel, AA407739, groupe, Bipolar Mood DisorderRheumatoid, rheumatic, Chronic rheumatic arthritis, Arthritis, Rheumatoid arthritis NOS (disorder), rheumatoid, susceptibility to, Case-Control Study, Rheumatoid arthritis NOS, Proliferative arthritis., Rheumatic gout, RA - Rheumatoid arthritis, Rheumatoid disease, RhA - Rheumatoid arthritis, Rheumatoid Arthritis, atrophic arthritis, autoimmune arthritis, Rheumatoid arthritis (disorder), rheumatoid arthritis, RA, progression of, arthritis, Arthritis or polyarthritis, atrophic Arthritis, arthritis or polyarthritis310.00.00.00.00.009561998766193708falseWTCCC case-control study for Rheumatoid ArthritisWTCCC genome-wide case-control association study for Rheumatoid Arthritis (RA) using the 1958 British Birth Cohort and the UK National Blood Service collections as controls. 2019-10-01 16:42:06EGAS00000000011960617554300EGAD00000000002EGAD00000000001EGAC00001000205EGAD00000000008EGAD00000000007