EGAGenomicsIllumina HiSeq 2000Cancer Genomicshttps://ega-archive.org/studies/EGAS00001000651EGAEGA study EGAS00001000651Mutational Signatures of relapse in rectal cancer FFPE samples in the CR07 clinical trialEGArestrictedRelapse, Rectal Neoplasm, Rectal, Cancer of the Rectum, carcinoma of the rectum, Rectum Neoplasm, Recrudescences, Rectal Cancers, Neoplasms, Recurrences, cancer of rectum, Tumor, Intervention Study., Rectum Cancers, Rectal Tumors, Rectal cancer, relapse, rectal cancer, Rectum Neoplasms, Recrudescence, carcinoma of rectum, Rectal Cancer, Neoplasm, Rectum Cancer, Rectal Tumor, cancer of the rectum, Relapses, Rectum, Cancer of Rectum, CancerRadiation Treatments, Policies, DNS, PhrB photolyase activity, Targeted Radiation Therapy, (Deoxyribonucleotide)n, neoplasia, Neoplasms, number, Rectal adenocarcinoma, Radiation Therapies, Surgery, photoreactivating enzyme activity, Tumor, pigmented epithelium, rhabdomyosarcoma, presence, Deoxyribonucleic acids, NEOPL, Mutations, Relative, relapse, Deoxyribonucleic Acid, 3, stratum pigmentosa retinae, NUP96, Relapses, preoperative procedures, epithelium, neoplasm, Upper Arm, Arm, thymus nucleic acid, MOS3, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, PRECOCIOUS, Recrudescences, cell process disease, tumor disease, Recurrences, neoplasm (disease), Intervention Study, pigmented retina, F23A5.3, stubby, Radiotherapies, Double Stranded, Brachium, Deoxyribonucleic acid, tumour, Targeted Radiotherapies, Recurrences., DNA cyclobutane dipyrimidine photolyase activity, SUPPRESSOR OF AUXIN RESISTANCE 3, Upper, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Clients, Therapies, Double-Stranded DNA, operative procedures, (Deoxyribonucleotide)m, Targeted Radiotherapy, deoxyribonucleic acids, tumor, DNAn, alveolar, F23A5_3, Neoplastic Growth, Tumors, Therapy, PRE, Relapse, X-ray therapy, Upper Arms, Radiation, Targeted Radiation, ARMS, Targeted Radiation Therapies, DNAn+1, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Targeted, intraoperative procedures, neoplastic disease, Double-Stranded, Client, RMS2, tumours, (Deoxyribonucleotide)n+m, shortened, rhabdomyosarcoma alveolar, read, count in organism, MODIFIER OF SNC1, neoplastic growth, Arms, retinal pigment, peroperative procedures, Recrudescence, Radiotherapy, rhabdomyosarcoma 2, Relative Risks, deoxyribonucleic photolyase activity, dipyrimidine photolyase (photosensitive), Amplification Refractory Mutation System, radiation therapy, ds-DNA, General, desoxyribose nucleic acid, retinal pigment layer, Adjuvant Chemotherapy, Relative Risk, RPE, Risk, photolyase activity, operative therapy, Risks, operations, radioisotope therapy, Radiation Treatment, Adjuvant, disease of cellular proliferation, p. pigmentosa retinae, phr A photolyase activity, Adjuvant Drug Therapy, DNA-photoreactivating enzyme, Drug Therapy, Patient, Brachiums, ds DNA, cardinality, perioperative procedures, Radiation Therapy, Desoxyribonukleinsaeure, Treatment, deoxyribonucleate pyrimidine dimer lyase (photosensitive), DNA, short, other neoplasm, NEOPLASMS BENIGN, Neoplasia, invasive proceduresfalseMutational Signatures of relapse in rectal cancer FFPE samples in the CR07 clinical trialThe CRO7 clinical trial recruited patients with clinically operable rectal adenocarcinoma. Patients were randomized to either pre-operative short course surgery followed by chemo-radiotherapy only in those patients at high risk of local relapse. Patients in both arms the received standard %-FU based adjuvant chemotherapy as per local policy. We intend to use FFPE derived DNA from the primary tumours to identify patterns of mutations or copy number alterations that are predictive of local or distant relapse.2017-07-26 15:39:25EGAS000010006519606EGAD00001000875EGAC00001000000