EGAGenomicsILLUMINA, Illumina HiSeq 2500Cancer Genomicshttps://ega-archive.org/studies/EGAS00001000983EGAEGA study EGAS00001000983SOFT study - sequencing premenopausal breast cancer (2017-11-22)EGArestrictedBreast Carcinoma, Human Mammary Neoplasm, primary breast cancer, Carcinoma, malignant tumor of the breast, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], short stature, SOFT, Neoplasms, mammary neoplasm, Mammary Cancers, Human Mammary Neoplasms, Tumor, "breast tumor" EXACT [NCI2004_11_17:C2910], soft, and hypotrichosis, Human, Breast Malignant Neoplasm, Breast Malignant Tumor, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Mammary Carcinomas, Breast Tumor, Neoplasm, Human Mammary Carcinoma, "mammary tumor" EXACT [CSP2005:2016-0671], NOS, breast tumor, cancer of the breast, PIX2, WDR51A, Malignant Neoplasm of Breast, Carcinomas, BC, study, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, Breast Neoplasm, Mammary Neoplasm, Mammary Carcinoma, Human Mammary Carcinomas, Cancers, Breast Malignant Neoplasms., "mammary neoplasm" RELATED [], Cancer of the Breast, breast cancer, cancer of breast, Malignant Tumor of Breast, Mammary, Mammary Cancer, Breast Tumors, Breast Cancer, facial dysmorphism, Breast Malignant Tumors, onychodysplasia, Cancer of Breast, Breast, mammary cancer, cancer, mammary tumor, breast, Tumors, CancerINAD1, Therapy, Hunter Carpenter Macdonald syndrome, KARAK syndrome, 6330412C24Rik, early onset of peripheral gangrene, short stature, neuroaxonal dystrophy, Women's Group, PLAN, SOFT, Women Groups, p110, PI3K, PLA2G6 neurodegeneration with brain iron accumulation, function, Client, Woman, Girl, soft, Concept, and hypotrichosis, Mutations, p110-alpha, infantile, disease management., infantile neuroaxonal dystrophy/atypical neuroaxonal dystrophy, Role Concept, neurodegeneration with brain iron accumulation caused by mutation in PLA2G6, CWS5, Roles, INAD, sensitive, Girls, Role, Alleviating interaction, Concepts, p110alpha, Hunter-Carpenter-McDonald syndrome, PIX2, WDR51A, sensitivity, treatment, hormones, Seitelberger disease, neuroaxonal dystrophy presenting with neonatal dysmorphic features, Women's Groups, Specificity, suppressive genetic interaction (sensu inequality), Treatments, included, endocrine, MCAP, allergic reaction, caPI3K, CLOVE, Specificity and Sensitivity, Patient, Therapeutic, Clients, Role Concepts, facial dysmorphism, Therapies, Sensitivity, onychodysplasia, Treatment, MCM, Phospholipase A2-associated neurodegeneration, other neoplasm, MCMTCfalseSOFT study sequencing premenopausal breast cancerOur project will examine the role of PIK3CA mutations and their sensitivity to endocrine therapies and its role, with the addition of complete ovarian suppression. We plan to test our hypotheses using tumour samples collected from patients enrolled in the SOFT/IBCSG24-02 clinical study (Suppression of Ovarian Function Trial – (NCT00066690). SOFT is a phase III trial that randomised 3066 premenopausal women to evaluate if adding ovarian suppression to adjuvant endocrine therapy will improve clinical outcomes.2017-11-24 14:50:51EGAS000010009839606EGAD00001003811EGAC00001000000