EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001001067EGAEGA study EGAS00001001067WGS data for MMML for Study EGAS00001002198WGSWGS data for MMML for Study EGAS00001002199RNA-SeqWGBSrestrictedEGAAfrican Lymphoma, d230, Burkitt-Type, Lymphocytic Leukemia, nodule, dTAFII250, DNA Methylations, Germinoblastoma, Tumor, EfW1, Malignant, Germinoblastic Sarcoma, Mutations, dmTAF[[II]]230, Malignant Lymphomas, dmTAF1, Burkitt's Lymphoma, Taf230, Lymphomas, TAF250, Reticulolymphosarcoma, Centers, Lymphocytic, Sarcomas, Taf200, Leukemia, dTAF[[II]]250, DNA methylation maintenance, Burkitt, TFIID TAF250, BL, Germinal, cel, cell, Burkitt Tumor, Burkitt lymphoma/leukaemia, Taf1p, Burkitt's tumour [obs], DNA methylation, Center, dTAF250, small Non-Cleaved cell Lymphoma, Malignant Lymphoma, Sarcoma, L3, L3 Lymphocytic, TAF, Methylations, Burkitt's, dTAF[[II]]230, TAF[[II]]250, Burkitts Leukemia, Burkitt's tumor NOS (morphologic abnormality), TAF200, Burkitt Cell Leukemia, l(3)84Ab, Burkitt Leukemia, BG:DS00004.13, TAFII-250, TAF250/230, Cell, dTAF230, Burkitt Cell, Burkitts Lymphoma., TAFII250, lymhpoid nodule, Reticulolymphosarcomas, Burkitts lymphoma, L3 Lymphocytic Leukemia, Burkitt Lymphoma, Germinal Centers, p230, Burkitt's lymphoma - disorder, TAF[[II]]250/230, lymph node central zone, TFIID, Germinoblastic Sarcomas, Germinoblastic, Burkitt's tumor, L3 Lymphocytic Leukemias, lymph node nodule, malignant lymphoma, Taf[[II]]250, Burkitt's lymphoma of unspecified site (disorder), TAF[[II]]230, Burkitt's Leukemia, Burkitts Tumor, Lymphoblastic, Burkitt's Tumor, TAF[II]250, Germinoblastomas, CG17603, TAF[[II]], DmelCG17603, Burkitt's type, Taf250, SR3-5, Lymphoma, Burkitt's tumor or lymphoma, African, DNA, Burkitt's lymphoma NOS (disorder), Burkitt's tumors (morphologic abnormality), Methylation, TAF230, lymph node activated zone, TAF1SNF2LT, African Lymphoma, B Cells, Materials, ALF2, DmelCG4528, Burkitt-Type, determination, Bursa-Dependent Lymphocytes, acetylglucosaminyltransferase-like protein, Feature, A1, B cell, Mbp1, Gene Expression Profile, Profiles, DNA Methylations, Tumor, Social Controls, NURF, Mutations, U2 snRNP, primary tumour, heir-1, myd, prevention and control, Formal Social Controls, signal transduction by protein phosphorylation, Centers, average, Histiocytic Lymphoma, dISWI, DNA methylation maintenance, Burkitt, like-acetylglucosaminyltransferase, reference sample, Genomes, SWI2, BL, diffuse large B-cell lymphoma, Germinal, Burkitt Tumor, Burkitt lymphoma/leukaemia, U2 snRNP B'' protein, SNF2L, Mbp-1, prevention., Burkitt's tumour [obs], DNA methylation, Signatures, vdir, Social, preventive measures, Center, small Non-Cleaved cell Lymphoma, Large Cell Lymphoma, SWI, ACF, B lymphocyte, Expression Signature, ISW, Transcriptomes, CG8625, Malignancies, Diffuse Large B-Cell Lymphoma, id3, single organism signaling, Tumors, VDIR, AA408400, preventive therapy, Tcfe2a, B Lymphocytes, gyltl1b-b, Burkitt's tumor NOS (morphologic abnormality), Expression Profiles, fs(1)A1621, signal transduction by conformational transition, XIdIIa, Burkitt Leukemia, liz, signal transduction by trans-phosphorylation, Gene Expression, signaling cascade, lymhpoid nodule, Burkitts lymphoma, Benign, MDDGA6, Expression Signatures, mKIAA0609, fs(1)1621, Idb3, lymph node central zone, Genetic Materials, L3 Lymphocytic Leukemias, lymph node nodule, Diffuse Large Cell, KIAA0609, Expression Profile, Burkitts Lymphoma, Genetic Material, acetylglucosaminyltransferase-like 1A, Large-Cell Lymphoma, CHRAC, CG4528, Transcriptome Profiles, fg, DmelCG8625, Burkitt's lymphoma of unspecified site (disorder), gyltl1b, itf1, Burkitts Tumor, mdc1d, Control, Benign Neoplasms, whole genome, Controls, Features, LARGE_HUMAN, Malignant Neoplasms, Diffuse Large-Cell, MDC1D, enr, signaling pathway, B-Lymphocyte, primary tumor, Material, Lymphoma, XIdIa, Cistron, DNA, XIdIb, Burkitt's lymphoma NOS (disorder), Burkitt's tumors (morphologic abnormality), Regulation, Methylation, Diffuse Histiocytic, Regulations, WGBS, Lymphocytic Leukemia, nodule, Transcriptome Profile, Neoplasms, Benign Neoplasm, xtcf-3, Gene, E12|E47, U1-A, Malignant, LARGE1, froggy, Gyltl1a, p140/ISWI, bhlhb21, TCF-3, Diffuse Large B Cell Lymphoma, fs(1)A16121, xidia, E12, Large Lymphoid Lymphoma, XId3, Burkitt's Lymphoma, NURF-140, ITF1, xid3, dNURF, AW209082, XIdI, Lymphocytic, DLBCL, whole genome bisulfite sequencing, B-cell, Leukemia, Genetic, Malignancy, SNF, Snf, MDDGB6, iswi, Profile, Hlh462, Tcf-3, E2A, LARGE, ISWI, Diffuse, Neoplasias, BPFD#36, Large-Cell, Diffuse Large Cell Lymphoma, signalling pathway, xtcf3, L3, Histiocytic Lymphomas, XIdx, L3 Lymphocytic, Pan2, Pan1, signal transduction by cis-phosphorylation, SNF/D25, Diffuse Large-Cell Lymphomas, Characteristics, Methylations, Tcf3, TCF3, anon-EP1279744.124, Controlled, Cancer, whole-genome shotgun bisulfite sequencing, Burkitt's, NURF140, Controlling, D25, Transcriptome, Malignant Neoplasm, E47, Burkitts Leukemia, Formal Social Control, Burkitt Cell Leukemia, bHLHb25, snRNP B'', e2a, Cistrons, ME2, Cell, E12/E47, Burkitt Cell, Characteristic, L3 Lymphocytic Leukemia, Burkitt Lymphoma, Social Control, Large B-Cell, Germinal Centers, chemical analysis, Gene Expression Signatures, Burkitt's lymphoma - disorder, Neoplasm, Gene Expression Signature, Burkitt's tumor, methylation, Large Cell, signalling cascade, Diffuse Large-Cell Lymphoma, malignant lymphoma, Shotgun bisulfite sequencing, HEIR-1, tcfe2a, Histiocytic, primary neoplasia, Burkitt's Leukemia, prophylaxis, p140, Lymphoblastic, Burkitt's Tumor, Bursa-Equivalent Lymphocyte, Cancers, snf1621, SNF2L1, Diffuse Histiocytic Lymphomas, Burkitt's type, signalling process, like-glycosyltransferase, control, Gene Expression Profiles, Diffuse Histiocytic Lymphoma, bHLHb21, Burkitt's tumor or lymphoma, African, SNF2LB, Nurf-140, regulation, assay, Signature, B-lymphocyte, Neoplasia, Large Lymphoid, dCHRAC, glycosyltransferase-like protein LARGE1, lymph node activated zone, WGSBSfalseIntegrated genomic, transcriptional and epigenomic analyses in germinal center-cell lymphomas link the mutation landscape with differential DNA methylation in Burkitt lymphomaBiologically and clinically diverse B-cell neoplasms, including Burkitt, follicular and diffuse large B-cell lymphoma, show features of germinal center (GC) B-cells. Here we present a comprehensive analysis of the epigenetic landscape of GC-B-cell lymphomas using whole genome bisulfite sequencing paired with genome and transcriptome sequencing from 29 primary tumor samples and four normal GC-B-cell samples. All lymphomas studied showed extensive genome-wide methylation losses as well as intragenic regions where DNA methylation levels were strongly correlated with expression of associated genes. Pathway analysis revealed that these intragenic regions were enriched in signaling networks differentially activated in Burkitt and follicular lymphomas and affected regulatory mechanisms deregulated by recurrent mutations in a large fraction of Burkitt lymphomas (including the ID3/TCF3 complex, the SWI/SNF remodeling complex and the inhibitory G?I signaling pathway). Taken together, these results provide a global picture of Burkitt lymphoma pathomechanism and demonstrate a tight connection between epigenetic regulation and other levels of regulatory control in these tumors.2024-07-18 13:55:40EGAS000010010679606EGAD00001003208EGAD00001001121EGAD00001001120EGAD00001003276EGAD00001001119EGAC00001000010