EGAGenomicsIllumina HiSeq 2000Otherhttps://ega-archive.org/studies/EGAS00001001329EGAEGA study EGAS00001001329Carcinoma of the oral tongue (OTSCC) genomic landscape characterisationEGArestrictedCarcinomas, Anaplastic Carcinoma, Carcinoma, Spindle-Cell Carcinoma, Undifferentiated, Spindle Cell, Undifferentiated Carcinoma, epithelioma, Neoplasms, "carcinoma" EXACT [CSP2005:2000-1867], Epithelial Neoplasms, Malignant Epithelial Tumors, "carcinoma, glossus, Epithelial Neoplasm, Tumor, Epithelial Tumors, Malignant, Anaplastic, Undifferentiated Carcinomas, "epithelial carcinoma" EXACT [NCI2004_11_17:C2916], epithelial cancer, Epitheliomas, Spindle-Cell, "carcinoma NOS (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:189549006], Neoplasm, Malignant Epithelial Neoplasm, Spindle-Cell Carcinomas, Malignant Epithelial Neoplasms, Tongues., no subtype (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:68453008], Anaplastic Carcinomas, malignant Epithelioma, Malignant Epithelial Tumor, Malignant Epithelial, Epithelioma, Epithelial Tumor, Carcinomatosis, Carcinomatosesother disease, Incidences, Vapers, Neoplasms, Benign Neoplasm, Non-Tobacco Products Smoker, Person-time Rates, Malignant Epithelial Tumors, Cavity, Proportion, Prognostic Factors, glossus, Tumor, Epithelial Tumors, Malignant, rima oris, Intervention or Procedure, Secondary Attack Rate, Undifferentiated Carcinomas, Smokers, Cavitas Oris, Rate, "epithelial carcinoma" EXACT [NCI2004_11_17:C2916], diseases, disease or disorder, Vestibule of the Mouth, Tobacco, diseases and disorders, no subtype (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:68453008], Incidence Rate, Relapses, Oral Cavity, Malignant Epithelial, Epithelioma, Attack Rates, Carcinomatosis, Oral Cavity Proper, valve, Spindle-Cell Carcinoma, human disease, Undifferentiated, Prognoses, Malignancy, vestibulum oris, Oral, occurrence, interventionDescription, Recrudescences, Recurrences, mouth cavity, prevalence, Epithelial Neoplasms, Mouth Cavity Proper, Interventional, bucca, Cavitas oris propria, Tobacco Smokers, adult mouth, oral vestibule, genetic, non-neoplastic, Neoplasias, Cumulative, high frequency, Non-Tobacco Products Smokers, Vestibule Oris, time of survival, SURGICAL AND MEDICAL PROCEDURES., Clients, pharyngeal valve, Person-time, Person time Rate, cavity of mouth, disorder, Homo sapiens disease, Malignancies, malignant Epithelioma, Incidence Proportions, Non-Tobacco Products, constitutitional genetic, oral fissure, incidence, Cancer, Tumors, Relapse, Intervention Strategies, Carcinoma, Undifferentiated Carcinoma, Malignant Neoplasm, epithelioma, Attack Rate, Cumulative Incidence, frequency, Incidence, familial, disorders, "carcinoma" EXACT [CSP2005:2000-1867], Tobacco Smoker, Non Tobacco Products, "carcinoma, Secondary Attack, medical condition, Factor, Procedure, Vaper, Client, Anaplastic, Oral region, Cumulative Incidences, Incidence Rates, MT, Benign, cavitas oris, survival, epithelial cancer, Epitheliomas, Recrudescence, "carcinoma NOS (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:189549006], Diseases, Neoplasm, Spindle-Cell Carcinomas, anatomische Mund, Malignant Epithelial Neoplasms, cavum oris, condition, Person-time Rate, buccal cavity, outbreaks, Carcinomatoses, Carcinomas, Anaplastic Carcinoma, Intervention, Spindle Cell, Factors, frequent, death rate, Oral part of face, Prognostic, common, Benign Neoplasms, Smoker, Mouth, Cancers, Epithelial Neoplasm, surveillance, morbidity, endemics, Malignant Neoplasms, Secondary, disease, Incidence Proportion, Rima oris, Patient, Attack, Spindle-Cell, vestibule of mouth, Malignant Epithelial Neoplasm, epidemics, Anaplastic Carcinomas, inherited genetic, Malignant Epithelial Tumor, Epithelial Tumor, Secondary Attack Rates, oral cavity, hereditary, Tongues, Neoplasia, Females, Prognostic FactorfalseCarcinoma of the oral tongue (OTSCC) genomic landscape characterisationCarcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.2020-07-16 15:39:02EGAS000010013299606EGAD00001001465EGAC00001000374