EGAGenomicsAB 5500xl Genetic AnalyzerOtherhttps://ega-archive.org/studies/EGAS00001001353EGAEGA study EGAS00001001353Independent development of lymphoid and histiocytic malignancies from a shared early precursorEGArestrictedlod, parent ion, development, DmelCG2684, precursor ion, precursor., single-organism developmental process, Horka, postnatal development, CG2684, postnatal growth, Fs(3)Horka, DmF2, growth and development, Fs(3)Hor, NTef2, growth, Lds, early, Fs(3)Sz11Thymus-Dependent Lymphocytes, precursor lymphoblastic lymphoma/leukemia, single-organism developmental process, Lymphocytic Leukemia, HS, Complete Exome, Neoplasms, postnatal development, Benign Neoplasm, True Malignant Histiocytoses, acute lymphoblastic leukaemia, growth and development, T-Lymphocyte, Tumor, CG30327, Malignant, CG11478, T Lymphocyte, Whole Transcriptome, Transcriptome Sequencing, Lymphomas, immature T cell, Childhood ALL, hereditary., True Histiocytic Lymphoma, Lymphocytic, Histiocytic Lymphoma, Sarcomas, DmelCG42257, WES, Leukemia, Complete, Exome Sequencings, lymphoblastic leukaemia, Malignancy, Flexibility, T-Cells, Complete Exome Sequencing, Whole Transcriptome Sequencing, histiocytic sarcoma, T, Adult, Sequencing, genetic, Neoplasias, L2 Lymphocytic, T Cells, Acute Lymphoblastic, Sarcoma, True Histiocytic Lymphomas, Malignant Histiocytoses, L1, lymphoblastic leukemia, Whole Exome, L2, L1 Lymphocytic, Histiocytic Lymphomas, Clients, Precursor Cell Lymphoblastic Leukemia Lymphoma, Histiocytosis, 65K, mature T cell, Whole, True Histiocytic, CG42257, Dmel_CG30327, Acute lymphoblastic leukemia, Lymphoid, Malignancies, snp, constitutitional genetic, T Lymphocytes, Thymus Dependent Lymphocytes, Lymphocyte, Cancer, Tumors, ALL, sarcoma, cg11478, Malignant Neoplasm, Complete Exome Sequencings, True, malignant, Exome, familial, True Malignant Histiocytosis, Lymphoid Leukemia, Philadelphia-Positive, non-Langerhans-cell histiocytosis, non-Langerhans-cell, Client, L1 Lymphocytic Leukemia, Cell, Histiocytic Sarcomas, Lymphoblastic Lymphoma, development, Exome Sequencing, Benign, Acute Lymphoid Leukemia, T-Cell, CG6393, Neoplasm, Acute Lymphocytic, Acute Lymphoid, acute lymphocytic leukaemia, T lymphocyte, Lymphoblastic Leukemia, histiocytic, Dmel_CG6393, T-cell, Complete Transcriptome, Complete Transcriptome Sequencing, Histiocytic, Thymus-Dependent, True Malignant, postnatal growth, Lymphoblastic, Benign Neoplasms, Lymphocytes, Childhood, Acute Lymphoblastic Leukemia, Cancers, T-lymphocyte, Thymus-Dependent Lymphocyte, Malignant Neoplasms, Malignant Histiocytosis, Histiocytoses, Acute, T cell, Patient, Lymphoma, histiocytosis, Cells, Whole Exome Sequencing, L2 Lymphocytic Leukemia, T Cell, inherited genetic, other neoplasm, Transcriptome Sequencings, hereditary, growth, Acute Lymphocytic Leukemia, NeoplasiafalseIndependent development of lymphoid and histiocytic malignancies from a shared early precursorRecent reports have described lineage flexibility in patients with recurrent hematologic malignancies. We encountered a boy with T-lineage acute lymphoblastic leukemia, non-Langerhans cell histiocytosis and histiocytic sarcoma. All tumors showed identical T-cell receptor rearrangements, but SNP arrays and whole exome sequencing revealed unique aberrations in each tumor. From the genetic data we conclude that the tumors were derived from a precursor cell with lineage plasticity for both lymphoid and myeloid development. From this precursor cell, the tumors evolved with independent genetic progression in a non-linear manner.2017-07-26 15:39:26EGAS000010013539606EGAD00001001596EGAC00001000369