EGAGenomicsIllumina HiSeq 2500, ILLUMINACancer Genomicshttps://ega-archive.org/studies/EGAS00001001422EGAEGA study EGAS00001001422Precursor lesions, clonal architecture and relapse in Wilms nephroblastomaEGArestrictedMaterials, DNS, PhrB photolyase activity, (Deoxyribonucleotide)n, Transcriptome Profile, chemotherapy, Gene Expression Profile, Gene, pharmacotherapy, Profiles, Pharmacotherapies, photoreactivating enzyme activity, pigmented epithelium, Deoxyribonucleic acids, Chemotherapies, relapse, Deoxyribonucleic Acid, 3, stratum pigmentosa retinae, Relapses, NUP96, epithelium, Drug Therapies, proportion, thymus nucleic acid, MOS3, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, simple tissue., Genetic, Biopsies, PRECOCIOUS, Genomes, Recrudescences, Rests, proportionality to, Profile, Recurrences, Tissue, pigmented retina, F23A5.3, Double Stranded, Deoxyribonucleic acid, Signatures, DNA cyclobutane dipyrimidine photolyase activity, SUPPRESSOR OF AUXIN RESISTANCE 3, Expression Signature, Therapies, Transcriptomes, Double-Stranded DNA, (Deoxyribonucleotide)m, deoxyribonucleic acids, DNAn, F23A5_3, Therapy, Relapse, PRE, Transcriptome, DNAn+1, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Expression Profiles, Double-Stranded, Cistrons, (Deoxyribonucleotide)n+m, whole transcriptome, Gene Expression, MODIFIER OF SNC1, retinal pigment, Recrudescence, Expression Signatures, Gene Expression Signatures, deoxyribonucleic photolyase activity, dipyrimidine photolyase (photosensitive), Genetic Materials, Chemotherapy, Gene Expression Signature, ds-DNA, desoxyribose nucleic acid, Expression Profile, retinal pigment layer, Genetic Material, Transcriptome Profiles, RPE, Pharmacotherapy, photolyase activity, proportionality, rate, whole genome, p. pigmentosa retinae, Drug, phr A photolyase activity, DNA-photoreactivating enzyme, Material, Gene Expression Profiles, ds DNA, Desoxyribonukleinsaeure, quotient, Cistron, deoxyribonucleate pyrimidine dimer lyase (photosensitive), pharmacologic therapy, DNA, Signature, other neoplasmparent ion, Wilms' Tumor, Relapse, nonanaplastic renal Wilm's tumor, nonanaplastic renal Wilm's tumour, embryonal nephroma, Bilateral, Recrudescences, Wilms Tumor 1, Recurrences, nephroblastoma, childhood renal Wilms' cancer, Wilms tumor (nephroblastoma), Wilms tumor, precursor, Tumor, Nephroblastoma (disorder), Wilms, Wilm Tumor, Bilateral Wilms., childhood renal Wilms tumor, renal Wilms tumor, relapse, precursor ion, childhood renal Wilms tumour, adult renal Wilms' tumour, Recrudescence, Wilms' tumor, Nephroblastoma (morphologic abnormality), Bilateral Wilms Tumor, Relapses, WT1, Nephroblastomas, Wilms', Nephroblastoma NOS, Wilm's Tumor, Wilms Tumor, Nephroblastoma, adult nephroblastomafalsePrecursor lesions clonal architecture and relapse in Wilms nephroblastomaTargeted resequencing at high depth (21 genes, 9 chromosomal regions): at least 4 FFPE samples per case and matched germline DNA: • 100 cases with detailed outcome data, including 15 cases with tumour relapse (515 samples) • 40 cases with matched pre-chemotherapy biopsies (240 samples) • 50 nephrogenic rests matched to above cases (50 samples) We expect a proportion (possibly 10%) of cases to be mutationally silent on the above studies, and propose to subsequently carry out integrated whole-genome, methylome and transcriptome studies on matched frozen tissue from these cases2017-07-26 15:39:29EGAS000010014229606EGAD00001003217EGAC00001000000