{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"technology_type":["ILLUMINA, Illumina HiSeq 2000"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001001687"],"host":["EGA"],"description":["EGA study EGAS00001001687"],"dataset_title":["Clonal expansion of mutated cell population in bladder urothelium  (2018-08-03)","Clonal expansion of mutated cell population in bladder urothelium"],"category":["restricted"],"repository":["EGA"],"additional_accession":[]},"is_claimable":false,"name":"Clonal expansion of mutated cell population in bladder urothelium ","description":"1cm biospies of from patients undergoing bladder cystectomy will be collected.  The underlying muscle and stroma will be removed and the remaining epithelia dissected into small sequential areas which will be sent for ultra-deep exome sequencing using a panel of known cancer and viral genes.  Sequence analysis using similar methods to Martincorena I et al (Science 2015, 348:880) will provide an idea of the  somatic mutational landscape in these patient samples.  Individual patient muscle samples will also be sequenced as a reference.","dates":{"updated":"2018-08-07 11:51:03"},"accession":"EGAS00001001687","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001004274","EGAD00001003250","EGAC00001000205"]}}