{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001001799"],"host":["EGA"],"description":["EGA study EGAS00001001799"],"dataset_title":["Spiradenocarcinoma (2018-10-29)"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["Malignant Spiradenoma, Malignant eccrine spiradenoma, Carcinoma ex Eccrine Spiradenoma., Malignant Eccrine Spiradenoma, Spiradenocarcinoma"],"description_synonyms":["Scientific Bias, dp53, PhrB photolyase activity, Metastasis, Adenocystic, A4, sub-tegumental tissue, growth and development, eccrine spiradenoma, MYB, neoplasm metastasis, Tumor, CG3629, l(1)XVI, Wasbp, Case Fatality Rates, Solid-Cystic, dmTAF[[II]]230, Death Rates, Bronchial adenoma, Immunogold-Silver Techniques, parenchyma of lung, bbl, Epidemiologic Biase, symptoms, 1, Adenoid cystic carcinoma (morphologic abnormality), 3, NUP96, Excess Mortalities, myb, epithelium, gamma sarcoglycan, Ecological Biases, TFIID TAF250, BCC7, cel, cell process disease, tumor disease, beta-Tub6D, dmp53, T, tissue necrosis, 1422/04, subcutaneous adipose tissue inflammation, D17Mit170, Ba, SUPPRESSOR OF AUXIN RESISTANCE 3, ulcerative, aggressive behaviour, Immunogold-Silver Technic, Dp53, Statistical Biases, DIP, CG9045, scientific observation, Immunolabeling Technique, Homo sapiens disease, autolysin activity, Age-Specific Death Rate, CG17117, Epidemiologic Biases, p50/tubulin, Tumors, screening, CG10873, dTAF[[II]]230, Wiskott-Aldrich syndrome protein-interacting protein, xmyb, pulmo, dl, sudoriferous gland, WISH, lung parenchyma, Immunogold Technique, TAF200, Crude Death, tela subcutanea, Ecological Fallacies, Tl3, Tl2, Ki67, tumours, Outcome Measurement Errors, l(2)01092, Experimental, Benign, Adenoid Cystic, Immunolabeling Technic, bis(2-chloroethyl)sulfane, Recrudescence, Immunolabeling Technics, DIP-1, dipyrimidine photolyase (photosensitive), sarcoglycan, Technics, bfy, HTH, Hth, Carcinomas, Hidradenomas, Cylindromas, Adenoid, DLL, death rate, SH3 adapter protein SPIN90, Clear-Cell Hidradrenoma, follow up, N-WASP-binding protein, CG3401, signs, Benign Neoplasms, beta3Tub, beta3TUB, Immunogold Silver Techniques, Outcome Measurement, E(Arp), cmyb, Malignant Neoplasms, AGE, DTB3, Outcome Measurement Error, dll, Mortality Rate, pulmonary, subcutis, Taf250, Wiskott-Aldrich syndrome protein-binding protein, 35kD dystrophin-associated glycoprotein, bacteriolytic toxin activity, bhy, SPIN90, Cylindroid Adenocarcinoma, School-Age Population, Nodular Hidradrenoma, Mortality Determinant, other neoplasm, D-myb, hypoderm, ulcer, CG31325, Elderly, TAF230, ulcers, 54 kDa VacA-interacting protein, Adenocarcinoma, beta[[3]]-Tub, Immunogold-Silver, atypia, whole exome, DmelCG17117, DIP1, Neoplasms, Truncation, Excess, adenocystic carcinoma, Systematic Bias, 143391_i_at, superficial fascia, beta3 TU, Crude Mortality Rate, LFS1, dMyb, l(3)05745, NEOPL, Age-Specific Death, Ki-67, Rate, Determinant, l(2)387, lung, disease or disorder, panniculitis, Case Fatality, Cmyb, atypical, anon-EST:Liang-2.13, MAM, gamma-SG, neoplasm, Technique, Immunogold Silver Technics, DmMyb, DmMYB, Corium, Fallacies, Acrospiroma, School-Age Populations, Differential Mortality, Solid Cystic Hidradenoma, Excess Mortality, dTAF[[II]]250, cell, Recrudescences, cephalic area, Dmyb, ulceration, F23A5.3, tumour, NOS (except Cylindroma of skin, head and neck, Population, Subcutaneous tissue, Hidradrenoma, bis(2-chloroethyl) sulphide, Neoplasias, adenoid cystic cancer, dTAF250, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), accidental cell death, Clear-Cell, Crude Death Rates, DMyb, beta[[3]]-tubulin, tumor metastasis, 2.7, Neoplastic Growth, dmyb, Cancer, Hidradenoma, measuring, Fallacy, Dmbeta3, findings, Malignant Neoplasm, cou, Mortality Decline, 35 kDa dystrophin-associated glycoprotein, Immunogold Technic, 1-chloro-2-[(2-chloroethyl)thio]ethane, Metastases, prac, beta3t, disorders, Immunohistocytochemistry, Truncation Biases, BG:DS00004.13, defective, Cell, SGCG, nev, AF3p21, Acrospiromas, dTAF230, Metastase, Case Fatality Rate, neoplastic growth, N-acetyl-D-glucosamine 2-epimerase, Lr, MT, Adenocystic Carcinoma, Cystic Carcinoma, p53/tubulin, Neoplasm, TAF[[II]]250/230, condition, Solid-Cystic Hidradenoma, Death, Immunolabeling, Cystic Hidradenoma, Taf[[II]]250, CG33336, Death Rate, primary cancer, Immunocytochemistry, RPE, holin, DMDA1, increased number, D-p53, postnatal growth, Dm-P53, Cancers, beta3, 90 kDa SH3 protein interacting with Nck, disease of cellular proliferation, malignant tumor, School Age Populations, dtl, primary structure of sequence macromolecule, p. pigmentosa retinae, Tub, Cystic, Differential, Error, cribriform carcinoma, Aggregation Bias, betatub60D, ORF1, Clear Cell Hidradrenoma, Statistical Bias, Bra, Immunogold-Silver Technics, Decline, Immunolabeling Techniques, deoxyribonucleate pyrimidine dimer lyase (photosensitive), Statistical, Diaphanous protein-interacting protein, General activity, Neoplasia, NEOPLASMS BENIGN, AF3P21, Differential Mortalities, c-myb_CDS, WASLBP, MGC130048, Dm Myb, Activity, neoplasia, postnatal development, Neoplasm Metastases, Cylindroma (morphologic abnormality), Technic, pigmented epithelium, betaTub3, Tp53, cancer metastasis, School-Age, Techniques, c-Myb, Dm myb, DMP53, diseases, Immunogold-Silver Technique, Adenocystic Carcinomas, diseases and disorders, Dmp53, Ecological, inflammation of subcutaneous adipose tissue, Relapses, corium, Nodular Hidradrenomas, Art, 1323/07, increased, me75, c-myb, human disease, Crude Mortality Rates, neoplasm (disease), Iprit, Recurrences, pigmented retina, DmP53, T1, DNA cyclobutane dipyrimidine photolyase activity, Hidradrenomas, B3t, DmelCG3401, cephalic region, AI550390, CG14648, malignant neoplasm, CFR Case Fatality Rate, mustard gas, gamma-sarcoglycan, Ecological Bias, Malignancies, Eccrine Spiradenoma, Systematic, necrosis, tumor, subtegumental tissue, Immunogold Technics, PRE, Relapse, Carcinoma, Growl, myb1, Scientific, aberrant, Epidemiologic, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, SG-gamma, neoplastic disease, Adenoid Cystic Carcinomas, cylindroid, TAFII-250, TAF250/230, Sweat, Crude Mortality, 3t, Immunogold, Immunogold Techniques, eccrine spiradenoma of skin, TAFII250, Mortality, Gland, retinal pigment, WASP-interacting SH3-domain protein, DmelCG3629, School Age, RENBP, Cylindroma NOS, Diseases, BcDNA:LP01770, subcutaneous tissue, bacteriocin activity, median, Truncation Bias, DmelCG9045, retinal pigment layer, neoplasms, Tub60D, beta-tub, Populations, Clear-Cell Hidradrenomas, Bias, growth pattern, adenoid cystic carcinoma, non-developmental growth, DmelCG33336, Exomes, Mortalities, D630048A14Rik, gamma (35kDa dystrophin-associated glycoprotein), CG17603, Subcutaneous adipose tissue, TAF[[II]], En(Arp), Experimental Bias, loss of, cylindroma, disease, hth1, phr A photolyase activity, DMDA, lysin activity, Crude Death Rate, hth2, DNA-photoreactivating enzyme, Patient, M-82000), SR3-5, Dm-Myb, P53, p44, Dia-interacting protein 1, betaTub, accessory, Malignant Neoplasms., other disease, d230, SGCG_HUMAN, p50, Dm-myb, Ecological Fallacy, Mortality Declines, p53, benign eccrine spiradenoma, Benign Neoplasm, dTAFII250, Yperite, photoreactivating enzyme activity, Malignant, Cystic Hidradenomas, EfW1, mortality measurement, supernumerary, 54 kDa vimentin-interacting protein, TYPE, Spiradenomas, DAGA4, Mortality Determinants, Crude, dmTAF1, Taf230, 35DAG, cylindroid adenocarcinoma, stratum pigmentosa retinae, Low, Mustard gas, 1'-thiobis(2-chloroethane), SCG3, TAF250, 90 kDa N-WASP-interacting protein, Sweat Gland, tumor cell migration, Eccrine Spiradenomas, Taf200, Glands, cutis, MOS3, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, clone 2.13, Malignancy, PRECOCIOUS, D.m.BETA-60D, Aggregation, anon-WO0118547.126, head or neck, metastasis, Taf1p, growl, Age-Specific, dmMYB, Lost, non-neoplastic, Trp53, eccrine spiradenoma (morphologic abnormality), spiradenoma, aggression, Nodular, p85, Clients, Mortality Rates, betaTub60C, mortality rate, disorder, beta3-tubulin, spiroma/spiradenoma, DmelCG14648, TRP53, M16449, School Age Population, sudoriparous gland, TAF, Age Specific Death Rate, F23A5_3, sulfur mustard, Biase, beta-Tub60D, vertebrate hypodermis, VIP54, TAF[[II]]250, Dm-HTH, Solid-Cystic Hidradenomas, RnBP, BETA 60D, beta3-Tub, GlcNAc 2-epimerase, l(3)84Ab, medical condition, cephalic part of animal, Eccrine Acrospiroma, Client, LGMD2C, Xp53, development, MODIFIER OF SNC1, survival, p230, deoxyribonucleic photolyase activity, Cystic Carcinomas, Errors, sequence, TFIID, rare (European definition), Eccrine, beta[[3]] tubulin, Determinants, Cylindroma (except Cylindroma of skin, Rates, Eccrine Acrospiromas, TAF[[II]]230, photolyase activity, beta60C, Biases, Spiradenoma, Senfgas, l(3)86Ca, TAF[II]250, Age-Specific Death Rates, present in greater numbers in organism, Meis1, DmelCG17603, efg, glandula sudorifera, Indexes, vertebrate dermis, SCARMD2, Cylindroma, renin-binding protein, Lungs, ulcerated, variable, growth, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"Spiradenocarcinoma","description":"•\tSpiradenocarcinoma is a rare cutaneous sweat gland adnexal cancer with potential for aggressive behaviour. They are classified histologically into low- and high-grade tumours, with morphologically low-grade tumours thought to behave more favourably. However, limited information is available, with only 18 published cases.\n•\tWe have collected morphologically low-grade spiroadenocarcinomas (one with a lung metastasis) and high-grade spiroadenocarcinomas, as well as some spiradenomas (benign lesions),  cylindromas (another type of malignant cutaneous sweat gland adnexal tumour) and hybrid spiradenoma-cylindromas.\n•\tH&E-stained sections were reviewed, follow-up was obtained, and immunohistochemistry for Ki-67, p53 and, MYB has been performed. The tumours were solitary, measuring 0.8-7?cm (median: 2.7?cm), with a predilection for the head and neck of elderly patients (median age: 72 years; range 53-92) without gender bias. Histologically, the tumours were multinodular and located in deep dermis and subcutis. A pre-existing spiradenoma was present in all cases. The malignant component was characterized by expansile growth with loss of the dual cell population, up to moderate cytological atypia and increased mitotic activity (median: 10/10 HPF; range 1-28). Additional findings included squamoid differentiation (n=9), necrosis (n=7), and ulceration (n=5). P53 expression was variable and no significant differences were noted in the benign compared with the malignant parts of the tumours. In contrast, in the malignant components the Ki-67 proliferative index was slightly increased, and MYB expression was lost. Follow-up (median: 67 months; range: 13-132) available for 16 patients (84%) revealed a local recurrence rate of 19% but no metastases or disease-related mortality.\n•\tHere we wish to exome sequence these cases to define the first genomic landscape for this malignancy.","dates":{"updated":"2018-10-30 10:51:05"},"accession":"EGAS00001001799","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001004426","EGAC00001000205"]}}