{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"technology_type":["Illumina HiSeq 2000, PacBio RS II"],"study_type":["Other"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001001878"],"host":["EGA"],"description":["EGA study EGAS00001001878"],"dataset_title":["Whole genome SMRT sequencing in the HF-GBM-Tumor-Neurosphere-Xenograft study","Whole genome low pass sequencing data used in HF-GBM-Tumor-Neurosphere-Xenograft","Whole exome sequencing data used in HF-GBM-Tumor-Neurosphere-Xenograft","64 RNAseq BAMs in the HF-GBM-Tumor-Neurosphere-Xenograft study"],"category":["restricted"],"repository":["EGA"],"name_synonyms":["other disease, grade IV adult astrocytic tumour, Inheritance, DNS, (Deoxyribonucleotide)n, DNAn+1, disorders, medical condition, Double-Stranded, Giant Cell, Grade IV, Astrocytomas, Deoxyribonucleic acids, element, (Deoxyribonucleotide)n+m, adult glioblastoma multiforme, Deoxyribonucleic Acid, diseases, primary glioblastoma multiforme, Diseases, disease or disorder, condition, atomo, atomus, diseases and disorders, glioblastoma, ds-DNA, desoxyribose nucleic acid, atome, Giant Cell Glioblastomas, glioblastoma multiforme, thymus nucleic acid, human disease, Element, Glioblastoma, Drives, grade IV adult astrocytic tumor, spongioblastoma multiforme, atoms, Glioblastomas, GBM, Double Stranded, Deoxyribonucleic acid, Giant Cell Glioblastoma, Astrocytoma, non-neoplastic, disease, Glioblastoma Multiforme, Grade IV Astrocytomas, grade IV adult Astrocytic tumor, ds DNA, Desoxyribonukleinsaeure, disorder, Homo sapiens disease, Double-Stranded DNA, (Deoxyribonucleotide)m, Grade IV Astrocytoma, DNA, deoxyribonucleic acids, DNAn, elements, Grade IV., atom"],"description_synonyms":["other disease, 2-amino-4-(methylsulfanyl)butanoic acid, E 920, Hgfr, determination, Heterograft, Neoplasms, Benign Neoplasm, L-Zystein, 5730555F13Rik, TRANSPL HETEROL, Grade IV, Tumor, Transplantations, Astrocytomas, Malignant, heterologous transplantation, element, HGF, diseases, HGFR, disease or disorder, glioblastoma, diseases and disorders, F15E12.6, 2-amino-3-mercaptopropanoic acid, Cystein, RCCP2, Giant Cell Glioblastomas, treatment, C, F15E12_6, human disease, skeletal, grade IV adult astrocytic tumor, Receptor tyrosine kinase, pattern, Malignancy, MUB3_18, scatter factor receptor, cisteina, distribution, M, E-920, Heterografts, Hcys, Giant Cell Glioblastoma, MUB3.18, AUTS9, Astrocytoma, non-neoplastic, genetic, Neoplasias, Glioblastoma Multiforme, Xenotransplantations, 2-amino-4-(methylthio)butanoic acid, CYSTEINE, grade IV adult Astrocytic tumor, heterogeneity, disease management, Therapies, xenotransplant, disorder, FREE CYSTEINE, Homo sapiens disease, Malignancies, Grade IV Astrocytoma, AI838057, (2R)-2-amino-3-mercaptopropanoic acid, elements, RG7MT1, Nucleotide, metionina, constitutitional genetic, Racemethionine, receptor tyrosine kinase, atom, Heterologous, Cancer, Tumors, Therapy, grade IV adult astrocytic tumour, proto-oncogene c-Met, Malignant Neoplasm, DL-Methionine, PRO, disorders, 2-Amino-4-(methylthio)butyric acid, familial, medical condition, Giant Cell, 9130215G10Rik, Muscle, CYS, Cys, adult glioblastoma multiforme, XENOTRANSPL, Benign, primary glioblastoma multiforme, chemical analysis, Diseases, Neoplasm, condition, Methionin, atomo, atomus, Hmet, (2R)-2-amino-3-sulfanylpropanoic acid, atome, and GLY protein 2, Heterologous Transplantations, Zystein, Met, MET, ATCMPG1, nucleotides, ATCMPG2, HGF receptor, HGF/SF receptor, glioblastoma multiforme, Xenograft, and GLY protein 1, Xenotransplantation, Glioblastoma, Element, Drives, Transplantation, spongioblastoma multiforme, 2-amino-3-sulfanylpropanoic acid, tyrosine-protein kinase Met, atoms, Glioblastomas, GBM, Benign Neoplasms, L-2-Amino-3-mercaptopropionic acid, HETEROL TRANSPL, (R)-2-amino-3-mercaptopropanoic acid, Xenografts, Cancers, hCMT1c, c-Met, Treatments, 2-Amino-3-mercaptopropionic acid, L-Cystein, Malignant Neoplasms, disease, Grade IV Astrocytomas, Therapeutic, alpha-amino-gamma-methylmercaptobutyric acid, E920, Treatment, inherited genetic, assay, Par4, other neoplasm, 5730455C01Rik, hereditary, Neoplasia, SF receptor, Malignant Neoplasms."],"additional_accession":[]},"is_claimable":false,"name":"Non-Mendalian inheritance of extrachromosal DNA elements can drive disease evolution in glioblastoma","description":"Genomic heterogeneity of glioblastoma (GBM) is suspected to contribute to the poor response to therapy of this disease. We compared molecular characteristics between primary GBM, neurospheres and orthotopic xenograft models derived from the same parental tumor. Driver alterations were in majority propagated from tumor to model systems. Extrachromosomal amplifications of MET, a proto-oncogene coding for a receptor tyrosine kinase, were detected in three primary GBM, largely discarded in neurospheres cultures, but resurfaced in xenografts. The clonal dynamics inferred by somatic single nucleotide variants (sSNVs) in MET-amplified samples diverged from the pattern delineated by the MET amplification event suggesting that the MET event and sSNVs were inherited in different manners. Our analysis shows that extrachromosomal elements are able to drive tumor progression.","dates":{"updated":"2018-02-19 13:51:03"},"accession":"EGAS00001001878","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001002214","EGAD00001002264","EGAD00001002219","EGAD00001002245","EGAC00001000268"]}}