EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001001901EGAEGA study EGAS00001001901Whole Genome Sequencing of Gingivo-buccal Cancer: ICGC-India Project_YR03EGArestrictedprimary cancer, Complete, Whole Genome, Republic of India., Malignant Neoplasm, Malignancy, Neoplasms, Complete Genome Sequencing, Benign Neoplasm, Genome Sequencing, Benign Neoplasms, Cancers, Tumor, Malignant, malignant tumor, Sequencing, Malignant Neoplasms, Neoplasias, Complete Genome, MT, Benign, malignant neoplasm, Whole, Neoplasm, Malignancies, Neoplasia, Cancer, TumorsForms, Activity, multiple endocrine neoplasia syndrome, human papilloma virus infection, Laboratory, Infestations and Infections, Cavity, Risk Factor Score, Tumor, Literacy Program, rima oris, Mutations, Cavitas Oris, Risk Factors, Exposure, Workshops, Associations, Oral Cavity, Research Activity, Laboratory Research, Oral Cavity Proper, vena portae hepatis, Correlates, Priorities, treatment, thymus nucleic acid, vestibulum oris, entire life cycle, Literacy, Comparative Genomics, HPV, mouth cavity, Tissue, purification, Boys, Cavitas oris propria, Workshop, adult mouth, Social, isolation and purification, Vestibule Oris, malignant neoplasm, Health Correlates, ELL1, Ell1, disease management, Therapies, HPV infection, Malignancies, Double-Stranded DNA, Infections and Infestations, deoxyribonucleic acids, Research Priority, DNAn, Tumors, Therapy, Exposures, Genomics, Multiple endocrine neoplasms, DmelCG10120, Comparative, Genome Sequencing, Research Priorities, Double-Stranded, Functional Genomics, tobacco, familial endocrine, Programs, portal vein, (Deoxyribonucleotide)n+m, Oral region, Program, Benign, cavitas oris, Complete Genome, Human Papilloma Virus Infection, anatomische Mund, cavum oris, Score, simple tissue, multiple endocrine adenomatosis, desoxyribose nucleic acid, Research and Development, Factors, Social Risk Factors, Risk, training, Oral part of face, Deoxyribonucleic acids., life, Adenomatosis, Benign Neoplasms, Infection and Infestation, Mouth, Educational Activities, Treatments, Malignant Neoplasms, Activities, Social Risk, Endocrine neoplasia, Health, Literacy Programs, multiple, Patient, C19orf17, Republic of India, chewing, common tobacco, ds DNA, vestibule of mouth, anon-WO0118547.278, DNA, multiple endocrine neoplasia syndrome(s), oral cavity, other neoplasm, Mdh-NADP, lifespan, DNS, primary hepatic portal vein, (Deoxyribonucleotide)n, Chewing, Neoplasms, Training, Benign Neoplasm, men syndromes, Multiple endocrine neoplasia, Human Papillomavirus infection, Malignant, Deoxyribonucleic acids, Structural, Deoxyribonucleic Acid, isolation, Functional, Vestibule of the Mouth, Environmental Exposures, Human papillomavirus infectious disease, valve, Risk Factor, Human papillomavirus caused disease or disorder, Catalogs, Complete, Whole Genome, Populations at Risk, Malignancy, teaching, Oral, Research, entire lifespan, Complete Genome Sequencing, Human papillomavirus, Mouth Cavity Proper, Educational Activity, multiple endocrine neoplasia, Double Stranded, Risk Score, bucca, Deoxyribonucleic acid, clinical infection, Sequencing, Population at Risk, oral vestibule, Neoplasias, Infestation and Infection, men syndrome, Educational, curriculum, Clients, Whole, pharyngeal valve, cavity of mouth, Social Risk Factor, Training Programs, primary hepatic portal veins, (Deoxyribonucleotide)m, Development and Research, oral fissure, Cancer, Malignant Neoplasm, whole blood, DNAn+1, Multiple Endocrine Neoplasia, MDH, Nicotiana tabacum var. Samsun, Factor, ME, Risk Factor Scores, Client, Environmental, Priority, MT, Nicotania tabacum, Familial endocrine adenomatosis, Research Activities, Neoplasm, Infection, MEN, Men, ds-DNA, Me, American tobacco, buccal cavity, Training Program, Human papilloma Virus infection, primary cancer, mem, patient, Cancers, men, malignant tumor, Poaceae style (narrow), Risk Scores, Human Papillomavirus Infection, PPP1R68, Rima oris, Therapeutic, Human papillomavirus disease or disorder, Desoxyribonukleinsaeure, Multiple endocrine adenomatosis, Treatment, Structural Genomics, Neoplasia, CG10120falseWhole Genome Sequencing of Gingivo-buccal Cancer: ICGC-India Project YR03As a part of the ICGC, India has undertaken genomic studies on gingivobuccal cancer of the oral cavity, which is the most prevalent form of cancer among men in India. There are various known environmental (life-style) correlates of this cancer, the most important of which are tobacco chewing and HPV infection. Whole genome sequencing of paired DNA samples – isolated from the tumor tissue and from the blood of twenty five patients – have been performed to catalog germline and somatic mutations. Association between each observed genomic alteration and exposure to environmental risk factors is being explored. Detailed clinical characterization of the patients, collection of data on demographic and environmental exposures, and isolation of DNA samples from blood and tumor tissues collected from each patient are being done at the Advanced Centre for Research, Treatment and Education on Cancer, Mumbai. Whole genome sequencing is being performed at the National Institute of Biomedical Genomics, Kalyani. We have completed whole genome sequencing of paired blood and tumor DNA samples using Illumina HiSeq-2000 and 2500.2018-11-26 14:51:30EGAS000010019019606EGAD00001004478EGAC00001000010