EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001001933EGAEGA study EGAS00001001933The evolving mutational landscape of normal human esophagusSomatic mutant selection is altered by prior NOTCH1 mutation in ageing esophageal epitheliumMetabolic context regulates the competitive fitness of oncogenic PIK3CA mutant clones in the normal esophagusCompetitive selection of somatic mutant clones in normal human skin varies with body siteTargeted sequencing of Human esophageal epithelium microbiopsiesrestrictedEGAskin benign neoplasm, average, dermis plus epidermis plus hypodermis, the integument, region of skin, Oct-11a, skin, pelt, Otf-11, Skn-li, vertebrate integument, dermoid system, entire skin, skin zone, integumental organ, Skn-1a., SKIN, mKIAA0493, Epoc-1, epidermis, skin organ, portion of skin, skin plus hypodermis, vertebrate epidermis, Oct11, skin region, integument, BC033609, Fam91a1, Otf11, Skin-1a, entire integument, tegument, AV220772, Skin, dermal system, skin and subcutaneous tissue, integumentum communedermis plus epidermis plus hypodermis, the integument, region of skin, Oct-11a, Complete Exome Sequencings, DNS, wide/broad, pelt, (Deoxyribonucleotide)n, Complete Exome, Otf-11, Skn-li, DNAn+1, Exome, Maps, skin zone, integumental organ, Double-Stranded, broad, Deoxyribonucleic acids, epidermis, (Deoxyribonucleotide)n+m, Exome Sequencing, skin plus hypodermis, Oct11, skin region, Deoxyribonucleic Acid, epithelial, BC033609, Whole Transcriptome, Transcriptome Sequencing, Skin-1a, ds-DNA, tegument, desoxyribose nucleic acid, Skin, epitheliocyte, integumentum commune, Skn-1a, skin benign neoplasm, average, oesophageal epithelium, WES, Complete Transcriptome, thymus nucleic acid, Complete, Complete Transcriptome Sequencing, Exome Sequencings, skin, Complete Exome Sequencing, Whole Transcriptome Sequencing, vertebrate integument, dermoid system, entire skin, Double Stranded, Deoxyribonucleic acid, Skn-1a., SKIN, Sequencing, mKIAA0493, Epoc-1, skin organ, portion of skin, wide, Whole Exome, vertebrate epidermis, integument, Whole, Fam91a1, Otf11, ds DNA, Whole Exome Sequencing, Desoxyribonukleinsaeure, Double-Stranded DNA, (Deoxyribonucleotide)m, entire integument, DNA, deoxyribonucleic acids, DNAn, Transcriptome Sequencings, AV220772, dermal system, skin and subcutaneous tissuefalseMutant clone mapping in normal oesohagus and skinWe will use targeted exome sequencing to examine normal appearing oesophageal epithelium and skin to determine the mutational burden. DNA will be extracted from epithelia of a defined size and we will overlay positional information from the epithelial pieces to give clone maps over a wide area. This will be done in both oesophageal epithelium and skin2024-10-16 12:35:42EGAS000010019339606EGAD00001006194EGAD00001006969EGAD00001008281EGAD00001015261EGAD00001004158EGAD00001015256EGAC00001000000