{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Other"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001002092"],"host":["EGA"],"description":["EGA study EGAS00001002092"],"dataset_title":["DREAM SMC-HET - WGS mapped reads"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["CSEN, DREAM, KChIP3, heterogeneity., Kv channel-interacting protein 3, Dream/Strica, Dream, A-type potassium channel modulatory protein 3, CG7863, Csen, Nightmare, AI413860, Strica/Dream, STRICA, Mutations, R74849, STRICA/DREAM, strica, DmelCG7863, Nightmares, rKChIP3, Strica, KCHIP3, DRE-antagonist modulator, 4933407H12Rik, other neoplasm"],"description_synonyms":["submicrovillar cisterna, dmBest1, DREAM, KChIP3, Smc1, Dream, Tumor, composed of, DmelCG6264, Mutation Frequency, Mutations, dmTAF[[II]]230, School-Age, Techniques, Nightmares, Method, KCHIP3, ARB, Impacts, DRE-antagonist modulator, Mutation Frequencies, Environmental Impacts, BEST1_HUMAN, average, thymus nucleic acid, BWR1A, TFIID TAF250, cel, Moods, Tissue, composition, procedures, Nightmare, p45-BWR1A, Environmental Impact, K2p3.1, set, STRICA/DREAM, strica, Methodological Studies, malignant neoplasm, Malignancies, Double-Stranded DNA, deoxyribonucleic acids, HAP, DNAn, 4933407H12Rik, Frequency, Tumors, ITM, dTAF[[II]]230, ORCTL2, CG6264, GP91-3, TAF200, Double-Stranded, TAFII-250, Procedure, TAF250/230, (Deoxyribonucleotide)n+m, R74849, TAFII250, Benign, TBAK1, Frequencies, rKChIP3, School Age, Algorithm, simple tissue, desoxyribose nucleic acid, SLC22A1L, TU15B, Orctl2, dBest1, Populations, PPH4, content, dbest1, Heterogeneity, Benign Neoplasms, AW260131, Methodological, CG17603, TAF[[II]], DMC, Methodological Study, STRICA, Impt1, Malignant Neoplasms, Taf250, SR3-5, Strica, ds DNA, School-Age Population, DNA, HET, TASK-1, other neoplasm, 5330423C17Rik, TAF230, AU018122, Gruppe, BWSCR1A, d230, CSEN, DNS, Procedures, (Deoxyribonucleotide)n, Neoplasms, BEST1, infiltrating, Benign Neoplasm, Goal, dTAFII250, het, Csen, anon-WO0118547.380, Malignant, EfW1, Strica/Dream, Deoxyribonucleic acids, IMPT1, Rate, DmelCG7863, SMC, Deoxyribonucleic Acid, dmTAF1, Taf230, Genetic heterogeneity, Studies, SAF-B1, Mood, Technique, TAF250, School-Age Populations, Taf200, dTAF[[II]]250, Malignancy, cell, VMD2, A-type potassium channel modulatory protein 3, Double Stranded, Taf1p, Deoxyribonucleic acid, SAFB1, BMD, Population, AI413860, 3110021E02Rik, Genotypes, Neoplasias, Study, dTAF250, E130307D12, 10^[-6], grupos, heterogeneity, (Deoxyribonucleotide)m, School Age Population, TAF, Cancer, RP50, vitelliform macular dystrophy 2 (Best disease, nmf250, TAF[[II]]250, Malignant Neoplasm, grupo, SMITH-McCort dysplasia 1, Kv channel-interacting protein 3, OAT1, DNAn+1, l(3)84Ab, CG7863, BG:DS00004.13, Mischung, compositionality, Slc22a1l, Cell, group, dTAF230, Impact, Environmental, TASK, Affects., MT, Genogroup, p230, Mutation Rates, Neoplasm, TAF[[II]]250/230, TFIID, techniques, ds-DNA, Mutation, bestrophin), TSSC5, Taf[[II]]250, Rates, Dbest, primary cancer, TAF[[II]]230, ensemble, best, Dream/Strica, Rest, TAF[II]250, Cancers, malignant tumor, School Age Populations, Genogroups, DmelCG17603, structure, Environments, Desoxyribonukleinsaeure, D18386, groupe, BEST, Neoplasia, methodology, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"The ICGC-TCGA DREAM Somatic Mutation Calling - Tumour Heterogeneity Challenge","description":"Tumors are composed of many different cell types, ranging from the normal tissue micro-environment, infiltrating immune cells and tumour cells. This group of tumour cells is itself intrinsically highly heterogeneous, driven by the rapid mutation rate of cancer cells to become a mixture of different sub-populations. These different types of cells, called subclones, have different sets of mutations in their DNA. Because some subclones evolve from others, many subclones share mutations. While it is increasingly easy to determine what mutations are present in the tumor, it remains very difficult to determine which subclones have which mutations. The task of assigning mutations to subclones is called subclonal reconstruction.The ICGC-TCGA DREAM Somatic Mutation Calling - Tumour Heterogeneity Challenge (SMC-Het) is an international effort to improve standard methods for subclonal reconstruction: to quantify and genotype each individual cell population present within a tumor. The goal of this challenge is to identify the best subclonal reconstruction algorithms and to identify the conditions that affect their performance.","dates":{"updated":"2019-10-01 16:47:51"},"accession":"EGAS00001002092","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001003971","EGAC00001000514"]}}