EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001002416EGAEGA study EGAS00001002416The evolving mutational landscape of normal human esophagusSomatic mutant selection is altered by prior NOTCH1 mutation in ageing esophageal epitheliumCompetitive selection of somatic mutant clones in normal human skin varies with body siterestrictedEGAskin benign neoplasm, average, WGS, dermis plus epidermis plus hypodermis, the integument, region of skin, Oct-11a, skin, pelt, Otf-11, Skn-li, vertebrate integument, dermoid system, entire skin, skin zone, integumental organ, Skn-1a., SKIN, mKIAA0493, Epoc-1, epidermis, skin organ, portion of skin, skin plus hypodermis, vertebrate epidermis, Oct11, skin region, integument, BC033609, Fam91a1, Otf11, Skin-1a, entire integument, tegument, AV220772, Skin, dermal system, skin and subcutaneous tissue, integumentum communedermis plus epidermis plus hypodermis, the integument, region of skin, Oct-11a, DNS, wide/broad, pelt, (Deoxyribonucleotide)n, Otf-11, Skn-li, DNAn+1, Genome Sequencing, Maps, skin zone, integumental organ, Double-Stranded, broad, Deoxyribonucleic acids, epidermis, (Deoxyribonucleotide)n+m, skin plus hypodermis, Complete Genome, Oct11, skin region, Deoxyribonucleic Acid, epithelial, BC033609, Skin-1a, ds-DNA, tegument, desoxyribose nucleic acid, Skin, epitheliocyte, integumentum commune, Skn-1a, skin benign neoplasm, average, oesophageal epithelium, thymus nucleic acid, Complete, Whole Genome, skin, Complete Genome Sequencing, vertebrate integument, dermoid system, entire skin, Double Stranded, Deoxyribonucleic acid, Skn-1a., SKIN, Sequencing, mKIAA0493, Epoc-1, skin organ, portion of skin, wide, vertebrate epidermis, integument, Whole, Fam91a1, Otf11, ds DNA, Desoxyribonukleinsaeure, Double-Stranded DNA, (Deoxyribonucleotide)m, entire integument, DNA, deoxyribonucleic acids, DNAn, AV220772, dermal system, skin and subcutaneous tissuefalseWGS Mutant clone mapping in normal oesohagus and skinWe will use whole genome sequencing to examine normal appearing oesophageal epithelium and skin to determine the mutational burden. DNA will be extracted from epithelia of a defined size and we will overlay positional information from the epithelial pieces to give clone maps over a wide area. This will be done in both oesophageal epithelium and skin2024-10-16 12:36:52EGAS000010024169606EGAD00001004159EGAD00001015257EGAD00001006194EGAD00001015261EGAC00001000000