EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001002453EGAEGA study EGAS00001002453COLONOMICS Whole Exome SequencingCOLONOMICS small RNA sequencingAffymetrix SNP 6.0restrictedEGAAdenocarcinoma, colon tumor, Colon Neoplasm, Biological Markers, Viral Marker, Viral, malignant neoplasm of colon, Surrogate Endpoints, Surrogate Endpoint, determination, Clinical Markers, Laboratory, Immune Markers., Colon Adenocarcinomas, malignant, Clinical Marker, Neoplasms, Serum Markers, Biochemical, End Point, Endpoint, Colon Cancer, Biochemical Markers, Colon Adenocarcinoma, Serum, Biologic Marker, Adenocarcinomas, autosomal dominant, Immune Marker, Surrogate End Points, colon neoplasm, malignant colonic neoplasm, Surrogate Markers, Laboratory Markers, Colonic Cancers, Marker, Biological, Surrogate End Point, chemical analysis, Neoplasm, Colon Neoplasms, malignant tumor of colon, malignant colonic tumor, malignant tumour of colon, CRC, malignant tumor of the colon, malignant colon tumour, Biologic Markers, Biomarker, Colon Cancers, Serum Marker, Colonic, Clinical, End Points, Surrogate, susceptibility to, Biological Marker, Endpoints, Colonic Neoplasm, Colon cancer, Colonic Cancer, Cancers, Immunologic, Cancer of the Colon, Laboratory Marker, Colon, Surrogate Marker, large intestine cancer, malignant colon tumor, malignant colonic tumour, Immunologic Markers, colon cancer, Cancer of Colon, Immune, Markers, Biochemical Marker, Viral Markers, malignant tumour of the colon, malignant neoplasm of the colon, assay, cancer of colon, malignant colon neoplasm, Immunologic Marker, somatic mutation, Biologic, CancerBiological Markers, Viral Marker, Surrogate Endpoints, malignant neoplasm of colon, Laboratory, Muscularis Mucosae, neoplasia, Biochemical, Endpoint, Colon Cancer, DNA Methylations, Serum, Tumor, CG30327, Muscularis, CG11478, malignant colonic neoplasm, Laboratory Markers, Biological, malignant tumor of colon, malignant tumor of the colon, average, DmelCG42257, thymus nucleic acid, DNA methylation maintenance, Gene Expressions, Man (Taxonomy), cell process disease, tumor disease, neoplasm (disease), Tissue, hypoplasia, Colonic Cancer, DNA methylation, large intestine cancer, Epigenomic, Lamina, genetic, mucosa of organ, Immune, Markers, Viral Markers, Propria, malignant neoplasm of the colon, mucosa of organ part, Malignancies, stage, Tissue Donor, Double-Stranded DNA, cancer of colon, tumor, deoxyribonucleic acids, DNAn, somatic mutation, Tumors, Transplant Donor, Viral, Surrogate Endpoint, Transplant, Modern, Arts, familial, Semen Donors, Biochemical Markers, neoplastic disease, Colon Adenocarcinoma, Double-Stranded, Biologic Marker, Adenocarcinomas, tumours, (Deoxyribonucleotide)n+m, Colonic Cancers, Benign, Marker, CG6393, malignant colonic tumor, Donors, desoxyribose nucleic acid, Mucosal Tissue, Dmel_CG6393, Industrial, Industrial Arts, End Points, Epigenetic, tunica mucosa, susceptibility to, Benign Neoplasms, Immunologic, Laboratory Marker, Colon, human, Semen Donor, Malignant Neoplasms, Semen, Cancer of Colon, Patient, Biochemical Marker, Mucous Membranes, ds DNA, microarray, inherited genetic, DNA, Epigenetics, other neoplasm, malignant colon neoplasm, Ovum, Ovum Donors, Organ Donors, Methylation, Adenocarcinoma, colon tumor, Colon Neoplasm, whole exome, human being, DNS, (Deoxyribonucleotide)n, Clinical Markers, Clinical Marker, Colon Adenocarcinomas, Neoplasms, developmental stage, Benign Neoplasm, Gene, Malignant, autosomal dominant, Deoxyribonucleic acids, NEOPL, Surrogate End Points, Human, colon neoplasm, Surrogate Markers, Homo sapiens, reduced, Deoxyribonucleic Acid, Colon Neoplasms, malignant tumour of colon, tiny, neoplasm, Man, malignant colon tumour, study, Biomarker, Clinical, Colonic, Malignancy, Tissues, Biological Marker, Double Stranded, tumour, Deoxyribonucleic acid, Cancer of the Colon, region of mucosa, Expressions, mucous membrane, Transplant Donors, Neoplasias, malignant colon tumor, malignant colonic tumour, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), Immunologic Markers, Clients, 65K, CG42257, Dmel_CG30327, snp, Expression, (Deoxyribonucleotide)m, Ovum Donor, constitutitional genetic, Immunologic Marker, Methylations, Neoplastic Growth, Biologic, Cancer, Organ, small, cg11478, Mucosa, Malignant Neoplasm, malignant, DNAn+1, Serum Markers, End Point, Client, Immune Marker, Mucosal, neoplastic growth, Surrogate End Point, mucosal region, Mucosae, Neoplasm, Donor, CRC, Lamina Propria, ds-DNA, Biologic Markers, Membranes, Colon Cancers, Serum Marker, Organ Donor, underdeveloped, Surrogate, Endpoints, organ mucosa, Colonic Neoplasm, Colon cancer, Mucous, Cancers, Membrane, disease of cellular proliferation, Surrogate Marker, Illumina Genome Analyzer I., colon cancer, malignant tumour of the colon, Modern Man, Desoxyribonukleinsaeure, hereditary, Neoplasia, NEOPLASMS BENIGN, Mucosal Tissues, Immune MarkersfalseComprehensive Molecular Analysis of Colon Cancer for the Identification and Validation of New BiomarkersThis study aims to identify diagnostic and prognostic biomarkers in colon cancer and to study understand the complex genomic, genetic and epigenetic relationships with a multiomic approach. The study includes tumor and paired normal mucosa of 100 colon cancer patients diagnosed at stage II, untreated and with microsatellite stable tumours. Also 50 normal mucosa samples from healthy donors are included as reference. The samples have been analysed for gene expression with Affymetrix U219 array (available at GEO GSE44076), SNP/CNV with the Affymetrix 6.0 Human SNP array, for DNA methylation with the Illumina 450K array. Small RNAs were sequenced with the Solid technology and 42 of the tumours and paired normal mucosa DNA were whole exome sequenced with Illumina Genome Analyzer.2019-03-18 09:51:09EGAS000010024539606EGAD00001004826EGAD00001004827EGAD00010001253EGAC00001000662