EGAGenomicsILLUMINA, Illumina HiSeq 2500, Ion Torrent PGM, ION_TORRENTOtherhttps://ega-archive.org/studies/EGAS00001002662EGAEGA study EGAS00001002662Multisample2 WESMultisample2 AmpliconrestrictedEGADmel_CG6393, DmelCG42257, cg11478, WES, Complete Transcriptome, Complete, Complete Transcriptome Sequencing, Exome Sequencings, Complete Exome Sequencings, determination, Complete Exome Sequencing, Whole Transcriptome Sequencing, Exome, CG30327, Sequencing, CG11478, Exome Sequencing, Whole Exome, 65K, CG6393, Whole, chemical analysis, CG42257, Dmel_CG30327, Whole Exome Sequencing, snp, Whole Transcriptome, Transcriptome Sequencing, assay, Transcriptome Sequencings, Complete Exome.Prevalence, deceased, other disease, lumen, Malignant Neoplasm, Period Prevalence, Neoplasms, space, frequency, p53, Benign Neoplasm, number, disorders, Period Prevalences, medical condition, Cardiac Death, Tumor, Malignant, LFS1, End-Of-Life, presence, Tp53, Xp53, Mutations, count in organism, prophase chromosome, Point Prevalence, Cardiac, Benign, Period, diseases, bbl, Point Prevalences, post-mortem, Diseases, Neoplasm, disease or disorder, condition, Near-Death Experience, diseases and disorders, bfy, anatomical spaces, Death, outbreaks, lumen space, death, human disease, pattern, frequent, distinct, Malignancy, BCC7, Prevalences, occurrence, Determination of Death, distribution, interphase chromosome, follow up, prevalence, Benign Neoplasms, common, End Of Life, chromatid, Cancers, surveillance, morbidity, endemics, Malignant Neoplasms, non-neoplastic, Neoplasias, disease, high frequency, Trp53, Chromosome, Point, P53, p44, bhy, disorder, epidemics, s, Homo sapiens disease, Malignancies, TRP53, Neoplasia, incidence, Cancer, Tumors, Malignant Neoplasms.falseMultisample genomic analysis of solid childhood cancers using high resolution SNP-arrays, Whole Exome Sequencing and Targeted Deep Sequencing.We mapped the prevalence of genetically distinct clones over 248 regions in 54 childhood cancers. This revealed that primary tumors can simultaneously follow up to four evolutionary patterns in different anatomic areas. The most common pattern consists of a fluctuating presence over anatomic space of subclones with very few mutations. The second most common is a surprisingly stable coexistence, over vast areas, of clones with different changes in chromosome numbers. This is contrasted by a third, less frequent, pattern where a novel clone harboring driver mutations or structural chromosome rearrangements completely replaces its progenitor. The fourth and rarest pattern is the local emergence of a myriad of clones with TP53 inactivation. Strikingly, death from disease was limited to tumors exhibiting the two latter, most dynamic patterns.2018-03-19 09:50:58EGAS000010026629606EGAD00001004014EGAD00001004020EGAC00001000534