EGAGenomicsIllumina HiSeq 2000, ILLUMINAOtherhttps://ega-archive.org/studies/EGAS00001002778EGAEGA study EGAS00001002778Exome sequencing files for "A single mutant clone populates the pancreatic ductal system to generate coexisting neoplastic lesions"EGArestrictedCarcinoma, NEOPL PANCREATIC, Complete Exome Sequencings, determination, Neoplasms, malignant neoplasm of body of pancreas, pancreatic neoplasm, Exome, familial, Pancreas Cancer, pancreas, precursor, Pancreas Cancers, Pancreas Neoplasm, Pancreatic Neoplasm, Exome Sequencing, Ca tail of pancreas, Ca head of pancreas, Pancreatic Cancer, chemical analysis, Neoplasm, Pancreatic Acinar, pancreatic carcinoma, increased risk of pancreatic cancer, Whole Transcriptome, Transcriptome Sequencing, PANCREATIC NEOPL, Pancreatic, Cancer of the Pancreas, Pancreatic Carcinomas, PANCREAS NEOPL, Carcinomas, parent ion, malignant neoplasm of tail of pancreas, pancreatic tumor, WES, Complete Transcriptome, Complete, Cancer of Pancreas, Complete Transcriptome Sequencing, Exome Sequencings, Pancreatic Carcinoma, malignant neoplasm of head of pancreas, Acinar Carcinoma, Complete Exome Sequencing, Whole Transcriptome Sequencing, pancreatic cancer, Cancers, Pancreatic Cancers, Pancreas, Pancreatic Neoplasms, Sequencing, Pancreatic Acinar Carcinoma, Whole Exome, precursor ion, Ca body of pancreas, Whole, Whole Exome Sequencing, assay, PNCA, Pancreas Neoplasms, Transcriptome Sequencings, Pancreatic Acinar Carcinomas, Acinar Carcinomas, Complete Exome., pancreatic tumour, pancreas neoplasm, Cancerbig, Forms, other disease, d230, Materials, NEOPL PANCREATIC, GRP1/cytohesin 1, determination, Effects, adult stage, Neoplasms, developmental stage, Longterm., Benign Neoplasm, Pancreas Cancer, Gene, dTAFII250, pancreas, precursor, Tumor, EfW1, Malignant, Pancreas Cancers, brl, Pancreatic Neoplasm, Long Term, Mutations, CG11633, dmTAF[[II]]230, cytohesin/GRP1, large, DmelCG4114, Ca tail of pancreas, Ca head of pancreas, diseases, dmTAF1, Pancreatic Cancer, Taf230, GRP1, Grp1, disease or disorder, cell proliferation disorder, diseases and disorders, Pancreatic Acinar, increased risk of pancreatic cancer, neoplasm, Effect, adult, TAF250, Pancreatic Carcinomas, PANCREAS NEOPL, Taf200, human disease, anatomical systems, dTAF[[II]]250, Genetic, TFIID TAF250, Malignancy, cel, Longterm, cell, Pancreatic Carcinoma, cell process disease, Acinar Carcinoma, PTPSTEP, l(2)SH2 0323, Taf1p, Pancreatic Cancers, Long-Term, genetic, non-neoplastic, Neoplasias, dTAF250, Neural-specific protein-tyrosine phosphatase, l(2)k08110, great, disorder, Homo sapiens disease, stage, Malignancies, Long-Term Effect, TAF, constitutitional genetic, Pancreatic Acinar Carcinomas, Long-Term Effects, pancreatic tumour, pancreas neoplasm, GPH, Cancer, Tumors, Carcinoma, "cell process disease" EXACT [], dTAF[[II]]230, TAF[[II]]250, Malignant Neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, familial, disorders, CG4114, TAF200, Longterm Effect, l(3)84Ab, stepk, medical condition, BG:DS00004.13, TAFII-250, TAF250/230, Cistrons, Pancreas Neoplasm, Cell, Expanded, dTAF230, TAFII250, Benign, p230, 1270, chemical analysis, Long Term Effects, Diseases, 3.1.3.48, Neoplasm, TAF[[II]]250/230, condition, TFIID, Genetic Materials, pancreatic carcinoma, PANCREATIC NEOPL, Pancreatic, Cancer of the Pancreas, Adults, l(2)SH0323, Genetic Material, parent ion, Carcinomas, CYH1, Taf[[II]]250, malignant neoplasm of tail of pancreas, pancreatic tumor, Cancer of Pancreas, TAF[[II]]230, distinct, Step, CG11628, malignant neoplasm of head of pancreas, expanded, pancreatic cancer, Ex, Benign Neoplasms, TAF[II]250, INSDC_feature:gene, Striatum-enriched protein-tyrosine phosphatase, Cancers, CG17603, TAF[[II]], Pancreas, Pancreatic Neoplasms, DmelCG11628, Longterm Effects, Pancreatic Acinar Carcinoma, Malignant Neoplasms, l(2)01270, disease, DmelCG17603, precursor ion, Taf250, enlarged, Ca body of pancreas, Material, STEP, SR3-5, l(2)ey, Cistron, inherited genetic, assay, PNCA, other neoplasm, hereditary, Pancreas Neoplasms, Neoplasia, Acinar Carcinomas, TAF230, TAF1falseEvolutionary analysis of pancreatic cancer and coexistent precursor lesions using whole exome sequencing dataMost adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. Further, the evolution of these lesions contextualizes the dynamics of advanced stage disease. We analyzed the somatic variants of co-existing pancreatic cancers and precursor lesions sampled from distinct regions of the same pancreas. After inferring evolutionary relationships, we found that the ancestral cell had initiated and clonally expanded to form one or more lesions, and that subsequent driver gene mutations eventually led to a pancreatic cancer. We also found that this multi-step progression generally spans many years. Our data suggest that independent, high-grade pancreatic lesions observed in a histologic cross section often represent a single neoplasm that can spread and colonize the ductal system, accumulating spatial and genetic divergence over time.2018-06-19 13:51:02EGAS000010027789606EGAD00001004044EGAC00001000588