EGAGenomicsTranscriptome Analysishttps://ega-archive.org/studies/EGAS00001002885EGAEGA study EGAS00001002885Profiling heterogeneity in Human derived IPSC-neurons (2020-05-18)EGArestrictedHuman, human being, iPSC, Nerve Cells, Man (Taxonomy), Homo sapiens, Modern Man, heterogeneity, Cells, Modern, Nerve, Neuron, iPS cell, Nerve Cell, Nerve., Man, human, CelldmBest1, d230, single-organism developmental process, PhrB photolyase activity, postnatal development, Nerve, Neurologic Diseases, Degenerative Neurologic Disorders, dTAFII250, growth and development, Neurologic Degenerative Condition, photoreactivating enzyme activity, anon-WO0118547.380, pigmented epithelium, Ximpact, EfW1, cerebral degeneration disease, DmelCG6264, Neurodegenerative Diseases, Publication., dmTAF[[II]]230, Publication, Neurologic Disorders, dmTAF1, Taf230, ARB, 3, stratum pigmentosa retinae, NUP96, epithelium, TAF250, imprinted and ancient gene protein, Nervous System Degenerative Diseases, study, Nervous System, Taf200, MOS3, Degenerative Condition, dTAF[[II]]250, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, TFIID TAF250, PRECOCIOUS, cel, cell, VMD2, pigmented retina, F23A5.3, Taf1p, BMD, Dietary Fiber, Neurodegenerative Disorder, Neurodegenerative Disorders, DNA cyclobutane dipyrimidine photolyase activity, SUPPRESSOR OF AUXIN RESISTANCE 3, genetic, dTAF250, Neurologic, Neurologic Degenerative Diseases, Degenerative Neurologic Disease, Degenerative Neurologic Diseases, Neurologic Degenerative Disease, Neuron, Spinal Cord, TAF, constitutitional genetic, Nerve Cell, Differentiation, F23A5_3, RP50, PRE, dTAF[[II]]230, TAF[[II]]250, Neurologic Disorder, CG6264, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, familial, TAF200, l(3)84Ab, BG:DS00004.13, TAFII-250, TAF250/230, impact-a, Cell, dTAF230, Degenerative Neurologic Disorder, development, TAFII250, MODIFIER OF SNC1, retinal pigment, p230, deoxyribonucleic photolyase activity, TAF[[II]]250/230, core, sequence, dipyrimidine photolyase (photosensitive), imprinted and ancient gene protein homolog, IMPACT, TFIID, TU15B, retinal pigment layer, Differentiations, dBest1, Taf[[II]]250, Degenerative Conditions, Dbest, RPE, TAF[[II]]230, Nerve Cells, best, Degenerative Diseases, photolyase activity, dbest1, postnatal growth, Neurologic Degenerative Conditions, TAF[II]250, Cell Differentiations, Neurologic Disease, CG17603, TAF[[II]], primary structure of sequence macromolecule, p. pigmentosa retinae, phr A photolyase activity, DmelCG17603, DNA-photoreactivating enzyme, Taf250, Degenerative, SR3-5, Cells, Neurodegenerative Disease, Central Nervous System, inherited genetic, deoxyribonucleate pyrimidine dimer lyase (photosensitive), E430016J11Rik, hereditary, growth, BEST, RWDD5, TAF230, TAF1falseProfiling heterogeneity in Human derived IPSC neuronsThe impact of genetic variants on molecular pathways that give rise to neurodegenerative diseases such as AlzheimerÂ’s and ParkinsonÂ’s is best elucidated in the appropriate cell types and molecular contexts. Existing studies have focused on bulk profiling of mixed cell types, but have ignored assaying genetic effects across development and cell differentiation. At the core of this proposal is the idea to use single-cell assays to study genetic effects during differentiation of dopaminergic and cortical neurons to identify the sequence of molecular events from variants to healthy and diseased cell states in a cell-specific manner. 1) This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see http://www.sanger.ac.uk/datasharing/2021-03-15 12:32:22EGAS000010028859606EGAD00001006157EGAC00001000205