EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001003186EGAEGA study EGAS00001003186AI_NF1glioma_WES_controlAI_NF1glioma_WESAI_NF1glioma_DNAmethAI_NF1glioma_RNAseqrestrictedEGARecklinghausens Disease of Nerve, Glioma 1, MGC130048, glial cell tumor, tumor predisposition syndrome, Neurofibromatosis Type 1, Neurofibromatosis (morphologic abnormality), GLM, RNA Sequence Determination, no ICD-O subtype" EXACT [SNOMEDCT_2005_07_31:74532006], glial tumors, Sequence Determination, RNA Sequence, A4, Mixed Glioma, DNA Methylations, tumour of the neuroglia, Tumor, "Neurofibromatosis 1" EXACT [MTH:U003314], Recklinghausen Disease, Recklinghausen Disease of Nerve, DmelCG8318, malignant Neuroglial tumor, [M]Glioma NOS (morphologic abnormality), type I, TPDS, tumor of the neuroglia, Peripheral, [M]Gliomas (morphologic abnormality), Whole Transcriptome, Transcriptome Sequencing, Neurofibromatosis, malignant" EXACT [SNOMEDCT_2005_07_31:189909006], Analysis, "glioma, tumor susceptibility linked to germline BAP1 mutations, well differentiated, adult, peripheral type, average, gamma sarcoglycan, Life Span, me75, DNA methylation maintenance, Neurofibromatosis 1, E030030H24Rik, glioma (morphologic abnormality), Analyses, Determination, entire life cycle, Length of Life, Complete Exome Sequencing, neuroglial tumour, Whole Transcriptome Sequencing, Neoplasm of the Neuroglia, type 1 neurofibromatosis, DNA methylation, Sequence Determinations, D17Mit170, T1, Neurofibromatosis Type I, tumour of neuroglia, Pulmonic Stenosis with Cafe au Lait Spots, Gliomas (morphologic abnormality), gamma-sarcoglycan, Malignancies, glioma, neoplasm of the neuroglia, Tumors, Glioma (except Nasal glioma, Lifespans, Watson, Exome, CG8318, SG-gamma, obsolete_glioma, Malignant Glioma, grade 1, "Recklinghausen's neurofibromatosis" EXACT [CSP2005:2012-7338], Tl3, Tl2, results, Determinations, Cafe-au-Lait Spots with Pulmonic Stenosis, Benign, Recklinghausen's disease, Pulmonic Stenosis with Cafe-au-Lait Spots, von Recklinghausen's Disease, sarcoglycan, Gliomas, Glial Cell Tumor, Peripheral Type, Adults, Recklinghausen's Disease of Nerve, dNF1, type 1 (disorder)" EXACT [SNOMEDCT_2005_07_31:92824003], neurofibromatosis type IV, Complete Transcriptome, Type 1 Neurofibromatosis, G1, life, Heterogeneity, common, Benign Neoplasms, Tumor of Neuroglia, gamma (35kDa dystrophin-associated glycoprotein), Children, Type 1, NF1 (Neurofibromatosis 1), Malignant Neoplasms, "malignant Neuroglial tumor" EXACT [NCI2004_11_17:C4822], DMDA, Patient, Recklinghausen's neurofibromatosis, Tumor of the Neuroglia, 35kD dystrophin-associated glycoprotein, glial tumour, Whole Exome Sequencing, grade I, not neoplastic), microarray, Glioma, WSS, glial neoplasm, DNA, neurofibromatosis type 1, malignant (morphologic abnormality), neurofibromatosis type 2, other neoplasm, Transcriptome Sequencings, Neoplasms of Neuroglia, Methylation, Malignant Neoplasms., Glioma NOS, "malignant glioma - category" EXACT [SNOMEDCT_2005_07_31:416500007], lifespan, neurofibromatosis type 4, SGCG_HUMAN, Peripheral Neurofibromatoses, Molluscum Fibrosum, low grade, Complete Exome, Neoplasms, Nerve, neuroglial tumor, Benign Neoplasm, Neuroglial Tumor, neurofibromatosis, Malignant, TYPE, DAGA4, Type I Neurofibromatoses, Genetic heterogeneity, 35DAG, "Neurofibromatosis, BAP1 tumor predisposition syndrome, Low, Type I, BAP1-related tumor predisposition syndrome, MAM, gamma-SG, Mixed Gliomas, SCG3, Acoustic neurofibromatosis, study, WES, Complete, Exome Sequencings, Glioma NOS (morphologic abnormality), Malignancy, entire lifespan, von Recklinghausens Disease, Glial Neoplasm, Nf-1, NFNS, VRNF, Sequencing, neuroglial neoplasm, Neoplasias, "malignant glioma (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:269505000], Whole Exome, glial tumor, RNA Sequence Analyses, Clients, Whole, Syndrome, RNA Sequencing, [M]Gliomas, NF1, NF-1, nf1, von Reklinghausen disease, Tumors of Neuroglia, Methylations, Lifespan, Cancer, Sequence Analyses, RNA, Malignant Neoplasm, Life Spans, cou, Complete Exome Sequencings, 35 kDa dystrophin-associated glycoprotein, RNA Sequence Determinations, Peripheral Neurofibromatosis, malignant, malignant glioma, "von Recklinghausen's disease" EXACT [MTHICD9_2006:237.7], Client, central Neurofibromatosis, neoplasm of neuroglia, SGCG, LGMD2C, Neurofibromatosis syndrome (disorder), Neurofibromatosis I, neurofibromatosis type 1 microdeletion syndrome, Exome Sequencing, Watson Syndrome, Lr, type IV neurofibromatosis of riccardi, Neurofibromatoses, Neoplasm, "Von Recklinghausen's disease" EXACT [SNOMEDCT_2005_07_31:81669005], "peripheral Neurofibromatosis" EXACT [NCI2004_11_17:C3273], Mixed, [M]Glioma NOS, Neuroglial tumor, Glial Tumor, NOS (except Nasal glioma, Complete Transcriptome Sequencing, Neuroglial Neoplasm, DMDA1, Neuroglial Neoplasms, peripheral Neurofibromatosis, Glial Cell, Malignant glioma, Von Recklinghausen disease, patient, Cancers, tumor of neuroglia, Cafe au Lait Spots with Pulmonic Stenosis, Neoplasm of Neuroglia, no ICD-O subtype, NF 1, RNA Sequence Analysis, SCARMD2, Glial Cell Tumors, Bra, AW494271, Malignant Gliomas, von Recklinghausen Disease, type 1" EXACT [MTHICD9_2006:237.71], NeoplasiaGlioma 1, Recklinghausens Disease of Nerve, Glioma NOS, Neurofibromatosis Type 1, Neurofibromatosis (morphologic abnormality), neurofibromatosis type 4, GLM, Peripheral Neurofibromatoses, Molluscum Fibrosum, glial tumors, neuroglial tumor, Nerve, Mixed Glioma, Neuroglial Tumor, tumour of the neuroglia, Tumor, neurofibromatosis, Malignant, Recklinghausen Disease, Recklinghausen Disease of Nerve, Type I Neurofibromatoses, [M]Glioma NOS (morphologic abnormality), type I, tumor of the neuroglia, Peripheral., [M]Gliomas (morphologic abnormality), Peripheral, Neurofibromatosis, Type I, Mixed Gliomas, Acoustic neurofibromatosis, peripheral type, glioma (morphologic abnormality), Neurofibromatosis 1, Glioma NOS (morphologic abnormality), neuroglial tumour, von Recklinghausens Disease, Neoplasm of the Neuroglia, type 1 neurofibromatosis, Glial Neoplasm, neuroglial neoplasm, glial tumor, Clients, Syndrome, tumour of neuroglia, Neurofibromatosis Type I, Gliomas (morphologic abnormality), Pulmonic Stenosis with Cafe au Lait Spots, [M]Gliomas, NF1, glioma, von Reklinghausen disease, Tumors of Neuroglia, neoplasm of the neuroglia, Tumors, Glioma (except Nasal glioma, Watson, malignant, Peripheral Neurofibromatosis, obsolete_glioma, Malignant Glioma, Client, neoplasm of neuroglia, central Neurofibromatosis, Neurofibromatosis syndrome (disorder), Neurofibromatosis I, neurofibromatosis type 1 microdeletion syndrome, Cafe-au-Lait Spots with Pulmonic Stenosis, Watson Syndrome, type IV neurofibromatosis of riccardi, Neurofibromatoses, Recklinghausen's disease, Pulmonic Stenosis with Cafe-au-Lait Spots, von Recklinghausen's Disease, Gliomas, Mixed, Glial Cell Tumor, [M]Glioma NOS, Peripheral Type, Recklinghausen's Disease of Nerve, Glial Tumor, NOS (except Nasal glioma, neurofibromatosis type IV, Type 1 Neurofibromatosis, Neuroglial Neoplasm, Neuroglial Neoplasms, peripheral Neurofibromatosis, Glial Cell, Malignant glioma, Von Recklinghausen disease, Tumor of Neuroglia, Type 1, NF1 (Neurofibromatosis 1), tumor of neuroglia, Neoplasm of Neuroglia, Cafe au Lait Spots with Pulmonic Stenosis, no ICD-O subtype, Patient, Tumor of the Neuroglia, Recklinghausen's neurofibromatosis, NF 1, glial tumour, Glial Cell Tumors, not neoplastic), Malignant Gliomas, Glioma, glial neoplasm, von Recklinghausen Disease, malignant (morphologic abnormality), neurofibromatosis type 1, neurofibromatosis type 2, Neoplasms of NeurogliafalseThe molecular landscape of glioma in patients with Neurofibromatosis 1.Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the most prominent tumor type. Gliomagenesis in NF1 results in heterogeneous spectrum of tumors, from low grade to high grade glioma, occurring during the entire patient lifespan. In this study, we present the molecular landscape of low- and high-grade glioma in children and adults affected by NF1 (NF1-glioma). 59 tumor samples from 56 NF1-glioma patients with 43 matched normal were profiled with Whole Exome Sequencing, DNA Methylation array (31 tumors) and RNA sequencing (29 tumors).2018-10-10 17:07:11EGAS000010031869606EGAD00001004374EGAD00010001610EGAD00001004375EGAD00001004376EGAC00001001004