EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001003227EGAEGA study EGAS00001003227Identification of molecular subgroups in multiple myeloma by whole exome sequencing.EGArestrictedPlasma-Cell Myelomas, Plasma-cell myeloma, Disease, Complete Exome Sequencings, Myelomas, Complete Exome, Myeloma, Multiple myeloma (disorder), Kahler's disease, Exome, Cell Myelomas, Myeloma Multiple, Myeloma-Multiples, Myeloma-Multiple, Multiple Myeloma, MM, Al amyloidosis, multiple myeloma, Exome Sequencing, Kahler, Multiple Myelomas, [M]Plasma cell myeloma, Myelomatoses, NOS, Whole Transcriptome, Transcriptome Sequencing, Myelomatosis, MULT MYELM W/O REMISSION, morphology (morphologic abnormality), Plasma-Cell, Plasma-Cell Myeloma, Plasmacytic myeloma, systemic, Plasma, amyloidosis, WES, Complete Transcriptome, no ICD-O subtype (morphologic abnormality)., Complete, Complete Transcriptome Sequencing, Exome Sequencings, Multiple myeloma, Complete Exome Sequencing, Whole Transcriptome Sequencing, Plasma Cell Myelomas, myeloma, Kahler Disease, Sequencing, Multiple myeloma without mention of remission, Multiple, Whole Exome, no ICD-O subtype, Cell Myeloma, multiple, Plasma Cell Myeloma, Whole, Whole Exome Sequencing, Multiple myeloma (clinical), Plasma Cell, Transcriptome Sequencings, myeloma - multipleRas1/RAs85D, para Tyrosine, RAS, Ras, RasV12, Complete Exome, dRas, E(sev)3C, DRAS1, neutral molecular compounds, DmelCG9375, Ras-1, Mutations, Dras1, ras, D-Ras, Whole Transcriptome, Transcriptome Sequencing, molecule, molecula, Dras, average, ras 1, WES, Complete, Exome Sequencings, molecules, dras1, RTK, Complete Exome Sequencing, Whole Transcriptome Sequencing, 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, Tissue, ras85B, Molekuel, ras85D, Y, Ras[V12], EK3-4, Sequencing, DRas, DRas85D/Ras, Ras 85D, set, Whole Exome, L Tyrosine, grupos, Tyr, Clients, Whole, Tyrosin, single organism signaling, l(3)s1747, Complete Exome Sequencings, grupo, Data Set, CG9375, Ras1, RAS1, Exome, 2-Amino-3-(p-hydroxyphenyl)propionic acid, para-Tyrosine, D-ras-1, Client, group, Tyrosine, E(faf), Exome Sequencing, fs(3)05703, tirosina, dRas85D, S35097, p21[Ras1], simple tissue, dRas1, dRAS1, ras1, Dras85D, Complete Transcriptome, RAS85D, Complete Transcriptome Sequencing, Dmras85D, ensemble, D-ras1, L-isomer, Rest, C-ras1, Dm Ras1, Su(tor)3-2, l(3)06677, L isomer, RasI, signalling process, Patient, Whole Exome Sequencing, L-Tyrosine, Transcriptome Sequencings, groupe, D-Ras1., GruppefalseWhole Exome Sequencing in Multiple MyelomaBy whole exome sequencing (WES) our group observed the accumulation of mutations in receptor tyrosine kinases (RTKs), adhesion molecules and their effectors and developed a signaling network that was affected by at least one mutation in almost 100% of MM patients and by more than one mutation in around 50% of MM patients which we decided to call inter- and intra-individual pathway redundancy. Interestingly, the extension of our WES dataset to 67 primary MM samples with correspond normal tissue which were collected at the Medizinische Klinik and Poliklinik II in Würzburg within the frame of the CRU216 has tentatively led to the designation of three molecular subgroups based on their mutation profile: "adhesion only", "adhesion & downstream" and "RTK & adhesion & downstream2022-11-01 15:22:18EGAS000010032279606EGAD00001004408EGAC00001000428