{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Whole Genome Sequencing"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001003254"],"host":["EGA"],"description":["EGA study EGAS00001003254"],"dataset_title":["Whole Genome Sequencing of 44 Chronic Lymphocytic Leukemia"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["leukemia, CLL, Cll, small lymphocytic lymphoma, c15, Complete, Whole Genome, B-cell chronic lymphocytic leukemia, DmelCG7937, Chronic Lymphocytic Leukemia, Complete Genome Sequencing, chronic LYMPHOCYTIC, lymphoplasmacytic leukaemia, Genome Sequencing, 311, study., lymphoplasmacytic leukemia, adult chronic leukaemia, chronic, B-cell chronic lymphocytic leukaemia, Sequencing, Ect5, cll, CML, Hox11-311, Complete Genome, 93Bal, B-cell chronic lymphoid leukemia, Whole, adult chronic leukemia, chronic lymphocytic leukaemia, chronic lymphatic leukemia, lymphocytic, chronic lymphatic leukaemia, chronic lymphatic, CG7937"],"description_synonyms":["leukemia, CLL, Cll, determination, Chronic Lymphocytic Leukemia, familial, number, chronic LYMPHOCYTIC, lymphoplasmacytic leukaemia, 311, high weight, Nrxn4, lymphoplasmacytic leukemia, not genetically inherited, Client, presence, chronic, B-cell chronic lymphocytic leukaemia, cll, CML, count in organism, 93Bal, Caspr, B-cell chronic lymphoid leukemia, p190, AI841080, chemical analysis, heavy, chronic lymphatic leukemia, Mutations., lymphocytic, shm, chronic lymphatic, nucleotides, small lymphocytic lymphoma, c15, B-cell chronic lymphocytic leukemia, distinct, Genomes, DmelCG7937, whole genome, adult chronic leukaemia, Ect5, genetic, Hox11-311, ch, Patient, Clients, cardinality, adult chronic leukemia, NCP1, chronic lymphocytic leukaemia, inherited genetic, assay, chronic lymphatic leukaemia, variable, Nucleotide, constitutitional genetic, hereditary, CG7937"],"additional_accession":[]},"is_claimable":false,"name":"46 CLL Whole Genome Sequencing Study","description":"Chronic lymphocytic leukaemia (CLL) consists of two biologically and clinically distinct subtypes defined by the abundance of somatic hypermutation (SHM) affecting the Ig variable heavy-chain locus (IgHV). The molecular mechanisms underlying these subtypes are incompletely understood. Here, we present a comprehensive whole-genome sequencing analysis of somatically acquired genetic events from 46 CLL patients, including a systematic comparison of coding and non-coding single nucleotide variants, copy number variants and structural variants, regions of kataegis and mutation signatures between IgHVmut and IgHVunmut subtypes.","dates":{"updated":"2018-10-15 10:51:02"},"accession":"EGAS00001003254","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001004384","EGAC00001001036"]}}