EGAGenomicsWhole Genome Sequencinghttps://ega-archive.org/studies/EGAS00001003254EGAEGA study EGAS00001003254Whole Genome Sequencing of 44 Chronic Lymphocytic LeukemiaEGArestrictedleukemia, CLL, Cll, small lymphocytic lymphoma, c15, Complete, Whole Genome, B-cell chronic lymphocytic leukemia, DmelCG7937, Chronic Lymphocytic Leukemia, Complete Genome Sequencing, chronic LYMPHOCYTIC, lymphoplasmacytic leukaemia, Genome Sequencing, 311, study., lymphoplasmacytic leukemia, adult chronic leukaemia, chronic, B-cell chronic lymphocytic leukaemia, Sequencing, Ect5, cll, CML, Hox11-311, Complete Genome, 93Bal, B-cell chronic lymphoid leukemia, Whole, adult chronic leukemia, chronic lymphocytic leukaemia, chronic lymphatic leukemia, lymphocytic, chronic lymphatic leukaemia, chronic lymphatic, CG7937leukemia, CLL, Cll, determination, Chronic Lymphocytic Leukemia, familial, number, chronic LYMPHOCYTIC, lymphoplasmacytic leukaemia, 311, high weight, Nrxn4, lymphoplasmacytic leukemia, not genetically inherited, Client, presence, chronic, B-cell chronic lymphocytic leukaemia, cll, CML, count in organism, 93Bal, Caspr, B-cell chronic lymphoid leukemia, p190, AI841080, chemical analysis, heavy, chronic lymphatic leukemia, Mutations., lymphocytic, shm, chronic lymphatic, nucleotides, small lymphocytic lymphoma, c15, B-cell chronic lymphocytic leukemia, distinct, Genomes, DmelCG7937, whole genome, adult chronic leukaemia, Ect5, genetic, Hox11-311, ch, Patient, Clients, cardinality, adult chronic leukemia, NCP1, chronic lymphocytic leukaemia, inherited genetic, assay, chronic lymphatic leukaemia, variable, Nucleotide, constitutitional genetic, hereditary, CG7937false46 CLL Whole Genome Sequencing StudyChronic lymphocytic leukaemia (CLL) consists of two biologically and clinically distinct subtypes defined by the abundance of somatic hypermutation (SHM) affecting the Ig variable heavy-chain locus (IgHV). The molecular mechanisms underlying these subtypes are incompletely understood. Here, we present a comprehensive whole-genome sequencing analysis of somatically acquired genetic events from 46 CLL patients, including a systematic comparison of coding and non-coding single nucleotide variants, copy number variants and structural variants, regions of kataegis and mutation signatures between IgHVmut and IgHVunmut subtypes.2018-10-15 10:51:02EGAS000010032549606EGAD00001004384EGAC00001001036